I-Dengue NS1 Antigen, IgM/IgG Antibody Dual

Umkhuhlane we-dengue yisifo esithathelwanayo esibangelwa ukulunywa omiyane besifazane abathwala igciwane le-dengue (DENV), esidluliselwa ngokushesha, ukwanda kwaso, ukusabalala kwaso okusabalele, kanye nokufa okuphezulu ezimweni ezimbi kakhulu.^.

Cishe abantu abayizigidi ezingu-390 emhlabeni wonke bangenwa yi-dengue fever minyaka yonke, kanti abantu abayizigidi ezingu-96 bathinteka yilesi sifo emazweni angaphezu kuka-120, ikakhulukazi e-Afrika, eMelika, eNingizimu-mpumalanga ye-Asia naseNtshonalanga yePacific. Njengoba ukufudumala komhlaba kukhuphuka, i-dengue fever manje isakazekela ezindaweni ezifudumele nezibandayo kanye nasezindaweni eziphakeme, futhi ukusabalala kwama-serotype kuyashintsha. Eminyakeni yamuva nje, isimo sobhubhane lwe-dengue fever sibi kakhulu esifundeni saseNingizimu Pacific, e-Afrika, eNingizimu Melika, eningizimu ye-Asia naseNingizimu-mpumalanga ye-Asia, futhi sibonisa amazinga ahlukene okwanda kohlobo lwe-serotype yokudlulisela, indawo yokuphakama, izinkathi zonyaka, izinga lokufa kanye nenani lokutheleleka.

Idatha esemthethweni ye-WHO ngo-Agasti 2019 ibonise ukuthi kwakunamacala angaba ngu-200,000 omkhuhlane we-dengue kanye nokufa kwabantu abangu-958 ePhilippines. IMalaysia yayiqoqe amacala angaphezu kuka-85,000 omkhuhlane we-dengue maphakathi no-Agasti 2019, kanti iVietnam yayiqoqe amacala angu-88,000. Uma kuqhathaniswa nesikhathi esifanayo ngo-2018, inani landa ngokuphindwe kabili emazweni womabili. I-WHO ibheke umkhuhlane we-dengue njengenkinga enkulu yezempilo yomphakathi.

Lo mkhiqizo uyikhithi yokubona ngokushesha, endaweni futhi enembile yegciwane le-dengue virus NS1 antigen kanye ne-antibody ye-IgM/IgG. I-antibody ethize ye-IgM ikhombisa ukuthi kukhona ukutheleleka kwamuva nje, kodwa ukuhlolwa kwe-IgM okungekuhle akufakazeli ukuthi umzimba awuthelelekile. Kubalulekile futhi ukuthola ama-antibodies athile e-IgG anesikhathi eside sokuphila kanye nokuqukethwe okuphezulu ukuqinisekisa ukuxilongwa. Ngaphezu kwalokho, ngemva kokuba umzimba usuthelelekile, i-antigen ye-NS1 ivela kuqala, ngakho-ke ukutholakala ngasikhathi sinye kwegciwane le-dengue NS1 antigen kanye nama-antibodies athile e-IgM kanye ne-IgG kungahlonza ngempumelelo impendulo yomzimba ku-pathogen ethile, futhi le kithi yokubona ehlanganisiwe ye-antigen-antibody ingenza ukuxilongwa okusheshayo nokuhlolwa kwasekuqaleni esigabeni sokuqala sokutheleleka kwe-dengue, ukutheleleka okuyinhloko kanye nokutheleleka kwesibili noma okuningi kwe-dengue, kufinyeze isikhathi sewindi futhi kuthuthukise izinga lokutholakala.