I-Clostridioides difficile isalokhu ingenye yezimbangela eziyinhloko zesifo.Izimbangela ezibaluleke kakhulu zohudo oluthelelanayo oluhambisana nokunakekelwa kwempiloemhlabeni wonke. Umthwalo ubaluleke kakhulu phakathi kweziguli esezikhulile, abantu abalaliswe esibhedlela, abahlala ezikhungweni zokunakekelwa kwesikhathi eside, kanye neziguli ezithola ama-antibiotic e-broad spectrum.
Kodwa ukuxilonga ukutheleleka kwe-C. difficile (CDI) kuletha inselele eyingqayizivele.
Ngokungafani nezifo eziningi ezibangelwa amagciwane esiswini, i-C. difficileigciwane elisebenzisa amathubaokungase kuhlale umgudu wamathumbu ngaphandle kokubangela izifo. Ukuthwala okungenazo izimpawu kuvame ukubonwa ezindaweni zokunakekelwa kwempilo, okusho ukuthi ukuba khona kwalesi sitho kuphela akusho ukuthi kukhona ukutheleleka okusebenzayo.
Lo mehluko phakathi kokungena ekoloni kanye nokutheleleka usenhliziyweni yokuxilongwa kwe-CDI yanamuhla.
Iyini i-CDI?
Isifo somtholampilo siqala lapho izinhlobo ze-toxigen zikhiqiza ubuthi obonakalisa i-mucosa yamathumbu, okuholela ezimpawini ezifana nalezi:
- · Uhudo olungachazeki
- · Ubuhlungu besisu
- · Imfiva
- · I-Leukocytosis
- · Isifo Sokuvuvukala Kwesikhumba
Ngokusho kokubuyekezwa kuka-2021 kwesiqondiso se-European Society of Clinical Microbiology and Infectious Diseases (ESCMID), ukuhlolwa kwelabhorethri kufanele kwenziwe ikakhulukazi ezigulini ezibonisa isifo sohudo esibalulekile emtholampilo esikisela i-CDI.
Lesi siqondiso sichaza isifo sohudo njengendle ekhululekile emithathu noma ngaphezulu zingakapheli amahora angama-24 futhi sigcizelela ukuthi okutholakele elabhorethri kufanele njalokufanele kuhunyushwe kanye nokwethulwa kwezokwelapha.
Umphumela omuhle welebhu wodwa akufanele ulinganiswe ngokuzenzakalelayo ne-CDI.
I-ESCMID: Ukuhlanganisa Ukuhlolwa Kwemitholampilo Nokuhlolwa Kwelabhorethri
Ukuze kuthuthukiswe ukunemba kokuxilonga ngenkathi kunciphisa ukuxilonga ngokweqile, i-ESCMID itusa indlela yokuxilonga enezinyathelo eziningi.
Isigaba sokuqala sokuhlola singasebenzisa:
- · I-Glutamate dehydrogenase (GDH), noma
- · Ukuhlolwa Kokukhulisa I-Nucleic Acid (NAAT)
Zombili lezi zindlela zinikeza ukuzwela okuphezulu ekutholeni iziguli ezine-C. difficile.
Uma kuqhathaniswa ne-GDH,I-NAAT inikeza ukucaciswa okuthuthukisiwe ngokuthola izakhi zofuzo ezihlobene nobuthi ezithwalwa izinhlobo ze-toxigenkunokuba nje kutholakale ukuthi kukhona yini isidalwa.
Kodwa-ke, i-ESCMID iphinde iphawule ukuthi ukuthembela ku-NAAT kuphela kungaholela ekuxilongweni ngokweqile ngoba izakhi zofuzo zobuthi zingatholakala kubantu abathwala izifo noma iziguli ezingenazo izifo ezihambisana nomtholampilo.
Ngenxa yalesi sizathu, imiphumela emihle yokuhlola ichazwa kahle kanye nemiphumela yokuhlolwa kwe-toxin immunoasy kanye nemiphumela yezokwelapha.
Leli qhinga lisiza ukuhlukanisa:
- · I-CDI esebenzayo
- · Ukuhlala ekoloni okungenazo izimpawu
- · Ukutheleleka kwesigaba sokuqala okudinga ukuhlolwa okwengeziwe kwezokwelapha
Ukuhlolwa kwe-CDI Okuqondiswe Kumhlahlandlela Osekelayo
Ukusekela amalabhorethri asebenzisa ukuhlolwa kwama-molecule ngaphakathi kwezindlela zokuxilonga ze-CDI, i-Macro & Micro-Test inikezaIkhithi Yokuthola I-Nucleic Acid ye-Clostridium difficile Toxin A/B Gene (i-Fluorescence PCR).
Ukuhlolwa kuhlonza ngqoi-tcdAfuthii-tcdBizakhi zofuzo ezivelaizibonelo zendle engakakhiwa, okuvumela ukuhlonza ngokushesha izinhlobo ze-toxigenic C. difficile.
Izinzuzo Eziyinhloko:
-Ukuzwela Okuphezulu nge-LoD ephansi njenge:200 CFU/mL/2,000 amakhophi/mL, okuvumela ukutholwa okuthembekile kwezinhlobo ze-toxigen ezisezingeni eliphansi.
-Ukuqondisa ubuthi A (i-tcdAkanye nobuthi B (i-tcdB) izakhi zofuzo, ukuhlolwa kukhomba ngqo izinhlobo ezikwazi ukukhiqiza izici eziyinhloko ze-virulence ezihlobene ne-CDI.
- Ukuhlanganiswa Kokuhamba Komsebenzi Okuguquguqukayo: kuhambisana namapulatifomu e-PCR ajwayelekile wesikhathi sangempela kanye nokuhlolwa okuzenzakalelayo ngokugcwele ku-Eudemon AIO 800
-Isitifiketi se-IVDR, esibonisa ukuhambisana nezidingo eziqinile ze-European In Vitro Diagnostic Regulation kanye nokusekela amalabhorethri kuzo zonke izimakethe zaseYurophu nezamazwe ngamazwe.
Ukunika Amandla Izinqumo Ezingcono Zezokwelapha
Ukuxilongwa kwe-CDI okunembile kudinga okungaphezu nje kokutholaC. kunzimaKudinga ukuhlanganiswa kwezimpawu zomtholampilo, okutholakele elabhorethri, kanye nokuqonda umehluko phakathi kokungena ekoloni kanye nokutheleleka.
Ihambisana nezincomo ze-ESCMID, i-NAAT ezwela kakhulu idlala indima ebalulekile ekutholeni izinto ezibangela ubuthiC. kunzimaizinkinga njengengxenye yesu eliphelele lokuxilonga i-CDI.
Ngezixazululo zayo zokuhlola ama-molecule eziqinisekiswe yi-IVDR, i-Macro & Micro-Test izibophezele ekusizeni ama-laboratories ukuthi alethe imiphumela esheshayo nethembekile esekela izinqumo zezokwelapha ezinolwazi, izinyathelo zokulawula ukutheleleka ezisebenzayo, kanye nemiphumela ethuthukisiwe yeziguli.
Isikhathi sokuthunyelwe: Juni-25-2026