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    • Amakhithi wokutholwa okuphelele we-MPOX (ama-Rdts, naaats nokulandelana)

    Kusukela ngoMeyi 2022, amacala eMpox abikwe emazweni amaningi angewona ama-endemic emhlabeni ngokuhanjiswa komphakathi.

    Ngo-26 Agasti, I-World Health Organisation (WHO) Wethule Umhlaba WonkeUkulungiswa kwamasu nohlelo lokuphendulaUkumisa ukuqubuka kokuhanjiswa komuntu kuya ekuntshontsheni komuntu kwe-MPOX ngokusebenzisa imizamo ehlanganisiwe yomhlaba, yesifunda kanye nangozwelonke. Lokhu kulandela ukumenyezelwa kwezimo eziphuthumayo zezempilo zomphakathi zokukhathazeka kwamazwe omhlaba yi-WHO MERTECT-General mhlaka 14 Agasti.

    Kumele kwaziwe ukuthi ukuqubuka kwe-MPOX kulokhu kuhlukile kulokho ngo-2022, okwakusakazeka kakhulu kubantu abaya ocansini nabantu, kanti nezinga lokufa kwabantu abanegciwane lalingaphansi kwe-1%.

    I-strain evamile yakamuva ethi "Clade IB", okuyinto ehlukile ye-Clade I, inesilinganiso esiphakeme sokufa kwabantu. Lokhu okuhlukile okusha kwaqala ukusakazeka eDRC Okokugcina ngoSepthemba ngoSepthemba, ekuqaleni phakathi kwabathengisa ngocansi, futhi manje sekubhekwane namanye amaqembu, nezingane zithambekele ikakhulukazi.

    I-CDC yase-Afrika ithe ngenyanga edlule lapho kuqubuka ama-MPOX emazweni ase-Afrika kulo nyaka, kufaka phakathi i-DRC, okubikwe 96.3% yawo wonke amacala e-Afrika kulo nyaka kanye no-97% wokufa. Kuyaqapheleka ukuthi cishe ama-70% amacala e-DRC yizingane ezingaphansi kweminyaka engu-15, futhi leli qembu libangela ama-85% okufa ezweni.

    I-MPOSIS yi-Zoososis ebangelwa yi-MPOX Virus ngesikhathi sokufakwa kwezinsuku ezi-5 kuye kwezingama-21, ikakhulukazi izinsuku ezi-6 kuye kwezingu-13. Umuntu onegciwane uzoba nezimpawu ezinjengomkhuhlane, ikhanda kanye nezindawo ezivuvukala ze-lymph nods, zilandelwa ukuqubuka ebusweni nakwezinye izingxenye zomzimba, ezikhula kancane zibe ama-pustule futhi zihlala isikhathi esingangesonto. Leli cala liyathethelela kusukela ekuqaleni kwezimpawu kuze kube yilapho amabala awela ngokwemvelo.

    I-Macro & Micro-Test ihlinzeka ngokuhlolwa okusheshayo, ama-molecular kits kanye nokulandelana kwezixazululo zokutholwa kwegciwane le-MPOX, ukubheka ukuxilongwa kwegciwane le-MPOX, ukubheka ukuvela kwalo, uhlu lwayo, ukuhambisa kanye nokuhlukahluka kwe-genomic:

    I-Monkeype virus antigenKit ukuthola (I-Immunochrotography)

    Isampula elula (Isampula ye-rash fluid / umphimbo) futhi umphumela osheshayo ungakapheli imizuzu eyi-10-16;

    Ukuzwela okuphezulu nge-lod of 20pg / ml isembozo sembozo emboza i & II;

    Ukucaciswa okuphezulu ngaphandle kokuqamba kabusha kwe-Crossport ngegciwane le-SCHPOX, i-varicella zoster virus, i-rubella virus, i-herpes simplex virus, njll.

    I-OPA ka-96.4% uma iqhathaniswa naaats;

    Isicelo esibanzi njengamasiko, ama-CDCs, amakhemisi, imitholampilo, izibhedlela noma ekhaya.

    I-monkeypox-virus IGM / Igg antibody dection(Immunochrotography)

    Ukusebenza okulula kwensimbi nokusebenza okusheshayo kungakapheli imizuzu eyi-10;

    Ukuzwela okuphezulu kanye nokucaciswa okumbozayo I-Clade I & II;

    Khomba i-IGM ne-IGG ukunquma izigaba zokutheleleka nge-MPOX;

    Isicelo esibanzi njengamasiko, ama-CDCs, amakhemisi, imitholampilo, izibhedlela noma ekhaya;

    Kufanelekile ekuhlolweni okukhulu kokutholakala kokutheleleka kwe-MPOX okusolwa.

    I-monkeypox virus rus nucleic acid detection detection detection

    Ukuzwela okuphezulu nge-Lod yamakhophi angama-200 / ml nge-IC, okulingana ne-Florescence PCR;

    Ukusebenza okulula: Isampula elinamathele elingezwe i-reagent reagent reagent ye-amplified eqondile evunyelwe enikezwe amandla amamojula azimele wohlelo olulula lwe-amp;

    Ukucaciswa okuphezulu ngaphandle kwesiphambano sokuvuselelwa ngegciwane lengxishongo, igciwane le-Voccinia, i-cowpox virus, i-herpepox virus, i-herpepox virus virus, i-varicella-zome virus, kanye ne-genome yomuntu, njll.

    Isampula elula (i-rash fluid / oropharyngeeal swab) kanye nomphumela omuhle kakhulu ngaphakathi kwemizuzu engu-5;

    Ukusebenza okuhle komtholampilo okuhlanganisa i-Clade I & II nge-PPA ka-100%, i-NPA ka-100%, i-OPA yenani le-100% ne-kappa liqhathaniswa ne-fluorescence PCR KIT;

    I-Lyophilesed version edinga kuphela ukuthuthwa kwamazinga okushisa kwegumbi nokugcina kunika amandla ukufinyeleleka kuzo zonke izifunda;

    Izimo eziguquguqukayo emitholampilo, isikhungo sezempilo, kanye ne-amp elula yokutholwa kwesidingo;

     

    I-monkeypox virus rus nucleic acid detection detection detection (Fluorescence PCR) 

    UGene gene ophindwe kabili oqondiswe ngokuzwela okuphezulu nge-lod yamakhophi angama-200 / ml;

    Isampula eguquguqukayo ye-fluid rash, umphimbo we-Throat ne-serum;

    Ukucaciswa okuphezulu ngaphandle kwesiphambano sokuvuselelwa ngegciwane lengxishongo, igciwane le-Voccinia, i-cowpox virus, i-herpepox virus, i-herpepox virus virus, i-varicella-zome virus, kanye ne-genome yomuntu, njll.

    Ukusebenza okulula: I-Rapid Sampula lyrnis ngesampula yokukhishwa kwesampula ukuze ingezwe ku-tube yokuphendula;

    Ukutholwa okusheshayo: kuphumela ngaphakathi kwamaminithi angama-40;

    Ukunemba okuqinisekiswe ngokulawulwa kwangaphakathi okuqondisa inqubo yokutholwa yonke;

    Ukusebenza okuhle komtholampilo okuhlanganisa i-Clade I & II nge-PPA ka-100%, i-NPA ka-99.40%, i-OPA yenani le-99.64% ne-Kappa liqhathaniswa nokulandelana;

    I-Lyophilesed version edinga kuphela ukuthuthwa kwamazinga okushisa kwegumbi nokugcina kunika amandla ukufinyeleleka kuzo zonke izifunda;

    Iyahambisana nezinhlelo ze-Mainstreance Fluorencence PCR;

    Izimo eziguquguqukayo zezibhedlela, ama-CDC nama-lab;

     

    Uhlobo lwe-Orthopox Virus Universal Uhlobo / I-Monsepox Virus nucleic acid detection detection detection detection

    Ukuhlanganiswa okugcwele: Kuvivinya wonke amagciwane ama-4 ama-Orthopox angathethelela umuntu kanye ne-Mpox evamile (i-Clade I & II efakiwe) esivivinyweni esisodwa ukugwema ukutholwa okukodwa;

    Ukuzwela okuphezulu nge-lod yamakhophi angama-200 / ml;

    Ukucaciswa okuphezulu ngaphandle kokuvuselelwa kwesiphambano namanye ama-pathogens abangela ama-rashes anjenge-herpes simplex virus, i-varicella-zoster virus, kanye ne-genome yomuntu, njll;

    Ukusebenza okulula: I-Rapid Sampula lyrnis yi-reagent yesampula yokukhishwa kwesampula ukuze ingezwe ku-buffer eyodwa yokuphendula ye-tube;

    Ukutholwa okusheshayo: I-Amplification Rapid enomphumela ngaphansi kwemizuzu engama-40;

    Ukunemba okuqinisekiswe ngokulawulwa kwangaphakathi okuqondisa inqubo yokutholwa yonke;

    Iyahambisana nezinhlelo ze-Mainstreance Fluorencence PCR;

    Izimo eziguquguqukayo zezibhedlela, ama-CDC nama-lab;

    MonkeypoxVakuthile TypingNumihlelezelayoAcigaDukukhiqizwaK(FI-LuoScence PCR)

    Ngakolunye uhlangothi ukhomba i-clade i kanye ne-clade II, okubalulekile ukuqonda izici zemvelo zegciwane, ukulandela ukudluliselwa kwayo, kanye nokwenza izindlela zokuvimbela nokulawula okuhlosiwe.

    Ukuzwela okuphezulu nge-lod yamakhophi angama-200 / ml;

    Isampula eguquguqukayo ye-rash fluid, i-oropharyngengeal swab ne-serum;

    Ukucaciswa okuphezulu ngaphandle kokuvuselelwa kwe-Cross I-I II kanye II, amanye ama-pathogens abangela ukuqubuka okufana ne-herpes simplex virus, i-varicella-woster virus, kanye ne-gec genome, njll;

    Ukusebenza okulula: I-Rapid Sampula lyrnis yi-reagent yesampula yokukhishwa kwesampula ukuze ingezwe ku-buffer eyodwa yokuphendula ye-tube;

    Ukutholwa okusheshayo: kuphumela ngaphakathi kwamaminithi angama-40;

    Ukunemba okuqinisekiswe ngokulawulwa kwangaphakathi okuqondisa inqubo yokutholwa yonke;

    I-Lyophilesed version edinga kuphela ukuthuthwa kwamazinga okushisa kwegumbi nokugcina kunika amandla ukufinyeleleka kuzo zonke izifunda;

    Iyahambisana nezinhlelo ze-Mainstreance Fluorencence PCR;

    Izimo eziguquguqukayo zezibhedlela, ama-CDC nama-lab;

    I-Monkey Virus Universal lonke GenmeUkubonaIsihlokwa nje (Multi-PCR NGS)

    I-monkes virus elisanda kuthuthukiswa i-monkes ephelele yokutholwa kwe-monkes nge-macro & micro-test for izimo ezihlukile, ihlanganiswe ne-Ont Nanopore Sequencer, ingathola ukulandelana kwe-ONT Nanopore, kungathola ukulandelana kwe-genopore konaphansi okungekho ngaphansi kwamahora angu-9. 

    Kulula ukusebenza kahle: Ubuchwepheshe be-amplishise ye-amplishise eyodwa obunelungelo lobunikazi, ukulandelana konke kwe-genome kwe-mpox virus kungatholwa nge-amplification eyodwa;

    Ukuzwela nokunembile: kutholwa amasampula aphansi kuya ku-32ct, kanye ne-600bp amplicon nanopore lokulandelana kungahlangana nomhlangano osezingeni eliphakeme le-genome;

    I-Ultra-Fast: Ont ingaqedela umhlangano we-genome kungakapheli amahora angama-6-8;

    Ukuvumelana okubanzindfuthi 3rdama-sequences wesizukulwane.

    Ultra-uzwelaI-Monkey Virus Volome yonkeUkubonaIsihlokwa nje-Illumina / MGI(Multi-PCR NGS)

    Mayelana nenani elikhulu le-2 ekhonandAma-sequences wesizukulwane emhlabeni wonke, iMacro & Micro-Test nawo athuthukise amakhithi azwelayo e-Ultra avumelanisa nabasekeli bezezimali ukuze bafeze ukulungiswa kwesampula kwe-genome ephansi;

    I-Amplification ephumelelayo: ama-1448 ngazimbili ze-200bp amplicon i-Ultra-mene primer design yokusebenza kahle kwe-amplication kanye nokuvalwa komfaniswano;

    Ukusebenza okulula: I-MPOX Virus Llumina / MGI Libraryle Library ingatholakala ngokukhuliswa okubili okujikelezayo ngamahora ama-4, ukugwema izinyathelo zokwakha ezinzima zokwakha kanye nezindleko ze-realent;

    Ukuzwela okuphezulu: Kuthola amasampula aphansi kuya ku-35ct, ngokuphumelelayo ngokugwema imiphumela emibi yamanga ebangelwa ukucekelwa phansi kwama-frompress noma inombolo ephansi;

    Ukuhambisana okubanzi nge-rainestream 2ndAma-sequences wesizukulwane esinjengeLLLumina, iSalus Pro noma i-MGI;Kuze kube manje, sekuqediwe amacala angaphezu kwama-400 omtholampilo.

    Isikhathi sePosi: Aug-28-2024
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