Njalo ngonyaka ngo-Ephreli 17 kuwuSuku Lomhlaba Lomdlavuza.
01 Uhlolojikelele Lwezehlakalo Zomdlavuza Womhlaba
Eminyakeni yamuva, ngokwanda okuqhubekayo kokuphila kwabantu nokucindezeleka kwengqondo, izigameko zamathumba nazo ziyanda unyaka nonyaka.
Izimila eziyingozi (umdlavuza) seziphenduke enye yezinkinga ezinkulu zezempilo zomphakathi ezibeka engcupheni impilo yabantu baseShayina.Ngokwemininingwane yakamuva yezibalo, ukufa kwezimila eziyingozi kubalelwa ku-23.91% wazo zonke izimbangela zokufa phakathi kwezakhamuzi, futhi izigameko nokufa kwezimila eziyingozi kuye kwaqhubeka nokukhuphuka eminyakeni eyishumi edlule.Kodwa umdlavuza awusho "isigwebo sokufa."Inhlangano yezempilo emhlabeni iWorld Health Organisation ikubeke kwacaca ukuthi inqobo nje uma isheshe yatholakala, u-60% -90% womdlavuza ungelapheka!Ingxenye eyodwa kwezintathu yomdlavuza iyavikeleka, ingxenye eyodwa kwezintathu yomdlavuza iyelapheka, kanti ingxenye eyodwa kwezintathu yomdlavuza ingelapheka ukuze kunwetshwe ukuphila.
02 Yini isimila
I-Tumor ibhekisela entweni entsha eyakhiwe ngokusabalala kwamangqamuzana ezicubu zendawo ngaphansi kwesenzo sezici ezihlukahlukene ze-tumorigenic.Ucwaningo luthole ukuthi amaseli e-tumor aba nezinguquko ze-metabolic ezihlukile kumaseli ajwayelekile.Ngasikhathi sinye, amaseli wesimila angakwazi ukuzivumelanisa nezinguquko endaweni ye-metabolic ngokushintsha phakathi kwe-glycolysis kanye ne-oxidative phosphorylation.
03 Ukwelashwa Komdlavuza Ngamunye
Ukwelashwa komdlavuza komuntu ngamunye kusekelwe olwazini lokuxilonga lwezakhi zofuzo eziqondiswe nesifo kanye nemiphumela yocwaningo lwezokwelapha olusekelwe ebufakazini.Inikeza isisekelo sokuthi iziguli zithole uhlelo olufanele lokwelashwa, oseluphenduke inkambiso yentuthuko yesimanje yezokwelapha.Ucwaningo lwezokwelapha luye lwaqinisekisa ukuthi ngokuthola ukuguqulwa kofuzo lwama-biomarker, ukuthayipha kwe-SNP yofuzo, isakhi sofuzo kanye nesimo saso samaprotheni kumasampula ezinto eziphilayo zeziguli zesimila ukubikezela ukusebenza kahle kwezidakamizwa nokuhlola ukubikezela, nokuqondisa ukwelashwa komuntu ngamunye emitholampilo, kungathuthukisa ukusebenza kahle futhi kunciphise okubi. ukusabela , ukukhuthaza ukusetshenziswa okunengqondo kwezinsiza zezokwelapha.
Ukuhlolwa kwamangqamuzana omdlavuza kungahlukaniswa ngezinhlobo ezi-3 eziyinhloko: ukuxilonga, ufuzo, kanye nokwelapha.Ukuhlolwa kokwelapha kuwumgogodla walokho okubizwa ngokuthi "i-pathology yokwelapha" noma umuthi womuntu siqu, futhi ayanda amasosha omzimba kanye nama-molecule amancane ama-molecule angakhomba izakhi zofuzo eziyisihluthulelo kanye nezindlela zokusayina zingasetshenziswa ekwelapheni izimila.
Ukwelashwa okuqondiswe kumamolekyuli kwamathumba kuqondise kuma-molecule omaka wamaseli wesimila futhi kuyangenelela enqubweni yamaseli anomdlavuza.Umphumela wawo ikakhulukazi kumaseli wesimila, kodwa unomphumela omncane kumaseli avamile.I-Tumor growth factor receptors, ama-molecule adlulisa isignali, amaprotheni omjikelezo wamaseli, izilawuli ze-apoptosis, ama-enzyme e-proteolytic, isici sokukhula kwe-vascular endothelial, njll. konke kungasetshenziswa njengezinhloso zamangqamuzana zokwelashwa kwesimila.Ngomhla zingama-28 kuZibandlela 2020, "Izinyathelo Zokulawula Zokusetshenziswa Komtholampilo Kwezidakamizwa Ze-Antineoplastic (Trial)" ezikhishwe yiKhomishana Yezempilo Kazwelonke Nezokwelapha ziveze ngokusobala ukuthi: Ezidakamizwa ezinezinjongo zofuzo ezicacile, umgomo wokuzisebenzisa kufanele ulandelwe ukuhlolwa kofuzo okuhlosiwe.
04 Ukuhlolwa kofuzo okuhloswe ngethumba
Kunezinhlobo eziningi zokuguqulwa kofuzo kumathumba, futhi izinhlobo ezahlukene zokuguqulwa kofuzo zisebenzisa izidakamizwa ezihlosiwe ezihlukene.Kuphela ngokucacisa uhlobo lokuguqulwa kwezakhi zofuzo nokukhetha ngendlela efanele ukwelashwa okuhlosiwe kwezidakamizwa lapho iziguli zingazuza khona.Izindlela zokutholwa kwamangqamuzana zasetshenziswa ukuze kutholwe ukuhlukahluka kwezakhi zofuzo ezihlobene nemithi evame ukuhloswe ngayo kumathumba.Ngokuhlaziya umthelela wezakhi zofuzo ekusebenzeni kwezidakamizwa, singasiza odokotela ukuba bakhe uhlelo lokwelapha olufanele kakhulu lomuntu ngamunye.
05 Isixazululo
I-Macro & Micro-Test ithuthukise uchungechunge lwezinsiza zokuhlonza i-tumor gene, ihlinzeka ngesixazululo esiphelele sokwelashwa okuqondiswe kwesimila.
Ikhithi Yokuthola Ukuguquka Kwezinguquko Ze-EGFR Yomuntu (Fluorescence PCR)
Le khithi isetshenziselwa ukutholwa kwe-in vitro ngendlela efanele uguquko oluvamile kuma-exons 18-21 wofuzo lwe-EGFR kumasampuli asuka ezigulini zomdlavuza wamaphaphu ongewona omncane.
1. Uhlelo lwethula ukulawulwa kwekhwalithi yereferensi yangaphakathi, engaqapha ngokucophelela inqubo yokuhlola futhi iqinisekise ikhwalithi yokuhlolwa.
2. Ukuzwela okuphezulu: Ukutholwa kwesisombululo sokusabela kwe-nucleic acid kungathola ngokuzinzile izinga lokuguqulwa elingu-1% ngaphansi kwesizinda sohlobo lwasendle olu-3ng/μL.
3. Ukucaciswa okuphezulu: Akukho ukusabela okuphambene ne-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
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I-KRAS 8 Mutations Detection Kit (Fluorescence PCR)
Le khithi ihloselwe ukutholwa kwekhwalithi ye-in vitro yezinguquko ezingu-8 kumakhodoni 12 no-13 ofuzo lwe-K-ras ku-DNA ekhishiwe ezigabeni zomuntu ezishumekwe ngupharafini.
1. Uhlelo lwethula ukulawulwa kwekhwalithi yereferensi yangaphakathi, engaqapha ngokucophelela inqubo yokuhlola futhi iqinisekise ikhwalithi yokuhlolwa.
2. Ukuzwela okuphezulu: Ukutholwa kwesisombululo sokusabela kwe-nucleic acid kungathola ngokuzinzile izinga lokuguqulwa elingu-1% ngaphansi kwesizinda sohlobo lwasendle olu-3ng/μL.
3. Ukucaciswa okuphezulu: Akukho ukusabela okuphambene ne-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
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I-EML4-ALK Fusion Gene Mutation Detection Kit yomuntu (Fluorescence PCR)
Le khithi isetshenziselwa ukuthola ngokufanelekile izinhlobo eziyi-12 eziguqukayo zofuzo oluhlanganisiwe lwe-EML4-ALK kumasampula eziguli ezinomdlavuza wamangqamuzana amancane we-in vitro.
1. Uhlelo lwethula ukulawulwa kwekhwalithi yereferensi yangaphakathi, engaqapha ngokucophelela inqubo yokuhlola futhi iqinisekise ikhwalithi yokuhlolwa.
2. Ukuzwela okuphezulu: Le khithi ingathola ukuguqulwa kokuhlanganiswa okuphansi okungamakhophi angu-20.
3. Ukucaciswa okuphezulu: Akukho ukusabela okuphambene ne-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
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I-ROS1 Fusion Gene Mutation Detection Kit yomuntu (Fluorescence PCR)
Le khithi isetshenziselwa ukutholwa kwekhwalithi ye-in vitro yezinhlobo eziyi-14 zokuguqulwa kofuzo lwe-ROS1 kumasampula omdlavuza wamaphaphu wengqamuzana ongewona omncane.
1. Uhlelo lwethula ukulawulwa kwekhwalithi yereferensi yangaphakathi, engaqapha ngokucophelela inqubo yokuhlola futhi iqinisekise ikhwalithi yokuhlolwa.
2. Ukuzwela okuphezulu: Le khithi ingathola ukuguqulwa kokuhlanganiswa okuphansi okungamakhophi angu-20.
3. Ukucaciswa okuphezulu: Akukho ukusabela okuphambene ne-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
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I-Human BRAF Gene V600E Mutation Detection Kit (Fluorescence PCR)
Le khithi yokuhlola isetshenziselwa ukuthola ngokufanelekile ukuguqulwa kofuzo lwe-BRAF lwe-V600E kumasampula ezicubu ezishunyekiwe zikapharafini zemelanoma yomuntu, umdlavuza we-colorectal, umdlavuza wegilo kanye nomdlavuza wamaphaphu in vitro.
1. Uhlelo lwethula ukulawulwa kwekhwalithi yereferensi yangaphakathi, engaqapha ngokucophelela inqubo yokuhlola futhi iqinisekise ikhwalithi yokuhlolwa.
2. Ukuzwela okuphezulu: Ukutholwa kwesisombululo sokusabela kwe-nucleic acid kungathola ngokuzinzile izinga lokuguqulwa elingu-1% ngaphansi kwesizinda sohlobo lwasendle olu-3ng/μL.
3. Ukucaciswa okuphezulu: Akukho ukusabela okuphambene ne-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
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| Inombolo Yekhathalogi | Igama Lomkhiqizo | Ukucaciswa |
| I-HWTS-TM012A/B | Ikhithi Yokuthola Ukuguquka Kwezakhi Zomuntu I-EGFR Gene 29 (Fluorescence PCR) | Izivivinyo eziyi-16/ikhithi, izivivinyo ezingama-32/ikhithi |
| I-HWTS-TM014A/B | I-KRAS 8 Mutations Detection Kit(Fluorescence PCR) | 24 test/kit, 48 test/kit |
| I-HWTS-TM006A/B | Ikhithi Yokuthola I-EML4-ALK Fusion Gene Mutation Detection (Fluorescence PCR) | 20 test/kit,50 test/kit |
| HWTS-TM009A/B | I-ROS1 Fusion Gene Mutation Detection Kit yomuntu (Fluorescence PCR) | 20 test/kit,50 test/kit |
| HWTS-TM007A/B | I-Human BRAF Gene V600E Mutation Detection Kit(Fluorescence PCR) | 24 test/kit, 48 test/kit |
| I-HWTS-GE010A | Ikhithi Yokuthola Ukuguqulwa Kwezakhi Zofuzo Yomuntu I-BCR-ABL (i-Fluorescence PCR) | Izivivinyo ezingama-24/ikhithi |
Isikhathi sokuthumela: Apr-17-2023