Ukutholwa Okubalulekile kwe-BCR-ABL Kokwelashwa kwe-CML

I-myelogenousleukemia engapheli (i-CML) isifo esibi se-clonal samaseli e-hematopoietic stem. Ngaphezu kwama-95% eziguli ze-CML zithwala i-Philadelphia chromosome (Ph) emaseli azo egazi. Futhi i-BCR-ABL fusion gene yakhiwa ngokufuduka phakathi kwe-ABL proto-oncogene (i-Abelson murine leukemia viral oncogene homolog 1) engalweni ende ye-chromosome 9 (9q34) kanye ne-breakpoint cluster region (BCR) gene engalweni ende ye-chromosome 22 (22q11). Iphrotheni yayo ye-fusion ebhalwe yileli gene inomsebenzi we-tyrosine kinase (TK), futhi isebenzisa izindlela zayo zokubonisana ezingezansi (njenge-RAS, PI3K, kanye ne-JAK/STAT) ukukhuthaza ukuhlukaniswa kwamaseli nokuvimbela i-apoptosis yamaseli, okwenza amaseli ande ngendlela enobungozi, ngaleyo ndlela abangele ukwenzeka kwe-CML.

I-BCR-ABL fusion gene, ebalulekile ekuthuthukisweni kwe-CML, isebenza njengophawu oluyinhloko lokuxilonga ye-CML. Ukutholwa kwayo kusiza ukuqapha isiguli'impendulo ye-s kuma-tyrosine kinase inhibitors (TKIs) futhi ibikezela ukuphinda kwe-leukemia, okubalulekile ekuphathweni kweziguli ze-CML okuphumelelayo.

I-BCR-ABL yomuntuIkhithi Yokuthola Ukuguquka Kwezakhi Zofuzo Ze-Fusionkusuka ku-Macro & Micro-Test ukuthola i-BCR-ABL ngokwekhwalithi ezigulini ze-CML, kusiza ukuxilongwa kwe-CML futhi kuqondisa ukwelashwa okuqondiwe kwezokwelapha ukwenza ngcono amasu okwelapha ukuze kuphathwe iziguli ngempumelelo. I-BCR-ABL fusion gene, okuyintokuyintokubalulekileekuthuthukisweni kwe-CML,isebenza njengophawu oluyinhloko lokuxilongaofI-CMLUkutholwa kwayo kusiza ekwenzeniimonithaisiguli'simpendulo kuma-tyrosine kinase inhibitors (ama-TKI)futhiibikezela ukuphinda kwe-leukemia, okusho ukuthiokubalulekileto kuyasebenzaI-CMLukuphathwa kweziguli.

Ikhithi Yokuthola Ukuguquka Kwezakhi Zofuzo Ze-BCR-ABL Yomuntu kusuka ku-Macro & Micro-Test ukuthola i-BCR-ABL ngokwekhwalithi ezigulini ze-CML, usizoI-CMLukuxilongwafuthiiziqondisoukwelashwa okuqondiwe kwezokwelaphatoi-optimizeamasu okwelapha okuphathwa kweziguli okuphumelelayo.

OkupheleleDukuqapha:Ngesikhathi esisodwaukutholwangoba3izakhi zofuzo ezivamile zokuhlanganiswa (P210, P190, P230)ngobaukumbozwa okubanzi kanyeukuvimbela amacala angabanjwanga;

Ukuzwela Okuphezulu:Uhlobo oluwuketshezi luthola izakhi zofuzo ezihlanganisiwenge-LoDamakhophi ayi-1000/mL,futhi inguqulo ephilizelisiweof Amakhophi angu-500/mL;

Kuhle kakhuluAukunemba: Iokwangaphakathiukulawulakanye ne-enzyme ye-UNG ukuvimbela imiphumela engamanga& izinto ezimbi;

Ukusebenza okulula nokusebenza kahle:Ukusebenza kwepayipi elivaliwe,ayinayo imikhiqizongemuva kokucutshungulwa,futhiukutholwangaphakathiImizuzu engama-60ngobaimiphumela eqotho nethembekile;

OkuningiIzinketho：Izinguqulo eziwuketshezi nezithambile zezinketho zamakhasimende;

Ukuhambisana Okubanzi:Iyahambisana nezinhlelo eziningi ze-PCR ukuze kufinyeleleke kabanzi elabhorethri.