Ukutholwa kwe-Bcr-abl-abl kokulashwa kwe-CML

I-MyElogenousleukemia (CML) yisifo esibi sesabekayo samangqamuzana we-hematopopoitic. Bangaphezu kuka-95% eziguli ze-CML ziphethe i-Philadelphia chromosome (PH) emangqamuzaneni egazi labo. Futhi i-Bcr-abl Fusion Gene yakhiwa isiphambano phakathi kwe-able proto-oncogene (abelson murine leukemia viral oncogene homog 1) engxenyeni ende ye-chromosome 9 (903) kanye neGCR) gene ye-BRECKITE (BCR) engozini ende ye-chromosome 22 (22Q11). Amaprotheni alo ahlanganiswe afakwe yile ntokazi anohlobo lomsebenzi we-Tystream Kinase (TK), futhi asebenze ama-ras asayina angenamishini (i-PI3K, kanye ne-jak / i-cell ukwenzeka kwe-CML.

I-Bcr-abl Fusion Gene, okubalulekile ekuthuthukisweni kwe-CML, isebenza njengophawu lokuxilonga olubalulekile ye-CML. Ukutholwa kwayo kusiza ukuqapha isiguli'Impendulo ye-tytrosine kinase inhibitors (TKIS) futhi ibikezela ukuphindaphinda kwe-leukemia, okubalulekile ekuphathweni kweziguli ze-CML ezisebenzayo.

I-Human Bcr-AblI-Fusion Gene Mutation Detection Kitkusuka ku-macro & micro-test for ukutholwa kwe-BCR-ABL ngeziguli ze-CCRL, Isiza ukuxilongwa kwe-CML kanye nemihlahlandlela ebhekiswe ekwelashweni kwemitholampilo Ukwenza kahle amasu wokwelapha wokuphathwa kweziguli okusebenzayo.bcr-abl Gene, okuyintoIs-nzimaEkuthuthukisweni kwe-CML,isebenza njengophawu olubalulekile lokuxilongaofCml. Ukutholwa kwayo kusiza ku-qapha-nesineke'sImpendulo ye-TKYROSINE KINASE inhibitors (TKIS)na-Ubikezela ukuphindaphinda kwe-leukemia, okusho ukuthi-funekayoto -phumelelayoCmlukuphathwa kweziguli.

I-Human Bcr-Abl Fusion Gene Mutation Dection Dection kusuka ku-macro & micro-test for ukutholwa kwe-BCR-AB-ABL ngeziguli ze-CCRL, isizaCmlukuxilongana-izikombaKubhekiswe ekwelashweni komtholampilo okuhlosiwetoI-OptiingeAmasu wokwelapha ukuphathwa okusebenzayo kweziguli.

-QondakalayoDI-Etect:-Kanye kanyeukubonaingomane3Uhlobo Lwama-Fusion olujwayelekile (P210, P190, P230)ingomaneukumbozwa okubanzi futhiUkuvimbela kusuka kumacala aphuthelwe;

Ukuzwela okuphezulu:Uhlobo lwe-Liquid luthola ufuzo lwe-Fusionnge-lodwamakhophi ayi-1000 / ml,na- inguqulo ye-lyophilisedof Amakhophi angama-500 / ml;

-Hle kakhuluACcuracy: I-asekunalukuphathakanye ne-enzyme ye-UNG ukuvikela ama-positive angamanga-Angathi-bi;

Ukusebenza okulula nokusebenza kahle:Ukusebenza okuvaliwe-ishubhu,mahhala yemikhiqizoukucubungula ngemuva,na-ukubonaphakathiImizuzu engama-60ingomaneimiphumela yenhloso nemiphumela ethembekile;

OkuningiIzinketho:Izinguqulo eziwuketshezi nezilolophilisiwe zezinketho zamakhasimende;

Ukuvumelana okubanzi:Ihambisana nezinhlelo eziningi ze-PCR zokufinyeleleka okubanzi.