Gxila empilweni yabesilisa yokuzala

Impilo yokuzala ihamba kuwo wonke umjikelezo wethu wokuphila, owawuthathwa njengenye yezinkomba ezibalulekile zezempilo yabantu yi-WHO.Ngaleso sikhathi, "Impilo yokuzala yabo bonke" ibonwa njengeNhloso Yokuthuthukiswa Okusimeme ye-UN.Njengengxenye ebalulekile yempilo yokuzala, ukusebenza kwesistimu yokuzala, izinqubo kanye nemisebenzi ibalulekile kuwo wonke umuntu wesilisa.

01 Izingoziofizifo zokuzala

Izifo zemigudu yokuzala ziwusongo olukhulu empilweni yabesilisa, okubangela inzalo ezigulini ezingaba ngu-15%.Ibangelwa kakhulu yi-Chlamydia Trachomatis, Mycoplasma Genitalium kanye ne-Ureaplasma Urealyticum.Kodwa-ke, cishe u-50% wabesilisa kanye nama-90% abesifazane abanezifo zemigudu yokuzala banganakwa noma abanazimpawu, okuholela ekuvimbeleni nasekulawuleni ukudluliselwa kwamagciwane akunakwa.Ukuxilongwa ngesikhathi nangempumelelo kwalezi zifo ngakho-ke kusiza endaweni enempilo yokuzala.

I-Chlamydia Trachomatis Infection (CT)

I-Chlamydia trachomatis urogenital tract infection ingabangela i-urethritis, i-epididymitis, i-prostatitis, i-proctitis kanye nokungazali emadodeni futhi ingase ibangele i-cervicitis, urethritis, isifo sokuvuvuka kwe-pelvic, i-adnexitis, nokungabi nabantwana kwabesifazane.Ngasikhathi sinye, ukutheleleka nge-Chlamydia trachomatis kwabesifazane abakhulelwe kungaholela ekuqhumeni kolwelwesi ngaphambi kwesikhathi, ukuzala umntwana oshonile, ukukhipha isisu okuzenzakalelayo, i-endometritis yangemva kokukhipha isisu nezinye izenzakalo.Uma ingelashwanga ngendlela efanele kwabesifazane abakhulelwe, ingadluliselwa zibheke phezulu ezinganeni ezisanda kuzalwa, ibangele i-ophthalmia, i-nasopharyngitis kanye nenyumoniya.Izifo ezingelapheki neziphindaphindayo ze-Chlamydia trachomatis ze-genitourinary zivame ukukhula zibe yizifo, njenge-cervical squamous cell carcinoma kanye nengculazi.

 I-Neisseria Gonorrhoeae Infection (NG)

Izimpawu zomtholampilo ze-Neisseria gonorrhoeae urogenital tract infection i-urethritis kanye ne-cervicitis, futhi izimpawu zayo ezijwayelekile i-dysuria, ukuchama njalo, ukuphuthuma, i-dysuria, i-mucus noma ukukhishwa kwe-purulent.Uma ingelashwa ngesikhathi, i-gonococci ingangena ku-urethra noma isakaze phezulu isuka emlonyeni wesibeletho, ibangele i-prostatitis, i-vesiculitis, i-epididymitis, i-endometritis, ne-salpingitis.Ezimweni ezimbi kakhulu, kungabangela i-gonococcal sepsis ngokusabalalisa kwe-hematogenous.I-mucosal necrosis ebangela i-squamous epithelium noma ukulungiswa kwezicubu ezixhumeneyo kungaholela ekuqineni komchamo, i-vas deferens kanye nokuncipha kweshubhu noma i-atresia ngisho nasekukhulelweni kwe-ectopic kanye nokungazali kubo bobabili abesilisa nabesifazane.

I-Ureaplasma Urealyticum Infection (UU)

I-ureaplasma urealyticum iyi-parasitic ikakhulukazi ku-urethra wesilisa, ijwabu lomthondo, kanye nesitho sangasese sowesifazane.Kungabangela izifo zomgudu womchamo kanye nokungabi nabantwana ngaphansi kwezimo ezithile.Isifo esivame kakhulu esibangelwa i-ureaplasma i-nongonococcal urethritis, eyenza amaphesenti angu-60 e-urethritis engabangelwa amagciwane.Kungase futhi kubangele i-prostatitis noma i-epididymitis emadodeni, i-vaginitis kwabesifazane, i-cervicitis, ukuzalwa ngaphambi kwesikhathi, ukuzalwa okunesisindo esiphansi, futhi kungabangela izifo zesimiso sokuphefumula kanye nesimiso sezinzwa ezimaphakathi zezingane ezisanda kuzalwa.

I-Herpes Simplex Virus Infection (HSV)

I-Herpes simplex virus, noma i-herpes, ihlukaniswe yaba izigaba ezimbili: uhlobo lwegciwane le-herpes simplex 1 kanye ne-herpes simplex virus uhlobo 1.I-Herpes simplex virus uhlobo 2 yisifo esithathelwana ngocansi esidala i-herpes yangasese.I-herpes yobulili ingaphindeka futhi ibe nethonya elikhulu empilweni yeziguli kanye nokusebenza kwengqondo.Kungase futhi kuthelele izingane ezisanda kuzalwa nge-placenta kanye nomgudu wokuzalwa, okuholela ekuthelelekeni kokuzalwa kwezingane ezisanda kuzalwa.

I-Mycoplasma Genitalium Infection (MG)

I-Mycoplasma genitalium iwumzimba omncane owaziwa ngokuziphindaphinda we-genome ongama-580kb kuphela futhi itholakala kabanzi kubantu nasezilwaneni.Kubantu abasha abathanda ucansi, kunokuhlobana okuqinile phakathi kokungajwayelekile kwepheshana le-urogenital kanye ne-Mycoplasma genitalium, kufika ku-12% weziguli ezinezimpawu ezibonisa ukuthi bane-Mycoplasma genitalium.Ngaphandle kwalokho, i-pepole ethelelekile i-Mycoplasma Genitalium ingabuye ithuthuke ibe yi-urethritis engeyona i-gonococcal kanye ne-prostatitis engapheli.Ukutheleleka kwe-Mycoplasma genitalium iyi-agent ezimele ye-causative yokuvuvukala komlomo wesibeletho kwabesifazane futhi ihlotshaniswa ne-endometritis.

I-Mycoplasma Hominis Infection (MH)

Ukutheleleka kwe-Mycoplasma hominis ye-genitourinary tract kungabangela izifo ezifana ne-non-gonococcal urethritis kanye ne-epididymitis emadodeni.Kubonakala njengokuvuvukala kwesimiso sokuzala kwabesifazane okusakazeka kugxile emlonyeni wesibeletho, futhi i-comorbidity evamile i-salpingitis.I-Endometritis kanye nesifo sokuvuvukala kwe-pelvic kungenzeka ngenani elincane leziguli.

02Isixazululo

I-Macro & Micro-Test ibambe iqhaza ngokujulile ekuthuthukisweni kwezipheshana ze-urogenital ezihlotshaniswa nezifo ezihlobene nokutheleleka, futhi ithuthukise amakhithi okuthola ahlobene (indlela ye-Isothermal Amplification Detection) kanje:

03 Ukucaciswa Komkhiqizo

Igama Lomkhiqizo	Ukucaciswa
I-Chlamydia Trachomatis Nucleic Acid Detection Kit (Enzymatic Probe Isothermal Amplification)	Izivivinyo ezingama-20/ikhithi Izivivinyo ezingama-50/ikhithi
I-Neisseria Gonorrhoeae Nucleic Acid Detection Kit (I-Enzymatic Probe Isothermal Amplification)	Izivivinyo ezingama-20/ikhithi Izivivinyo ezingama-50/ikhithi
I-Ureaplasma Urealyticum Nucleic Acid Detection Kit(Enzymatic Probe Isothermal Amplification)	Izivivinyo ezingama-20/ikhithi Izivivinyo ezingama-50/ikhithi
I-Herpes Simplex Virus Type 2 Nucleic Acid Detection Kit (I-Enzymatic Probe Isothermal Amplification)	Izivivinyo ezingama-20/ikhithi Izivivinyo ezingama-50/ikhithi

04 Aizinzuzo

1. Ukulawula kwangaphakathi kwethulwa kulolu hlelo, olungaqapha ngokucophelela inqubo yokuhlola futhi luqinisekise ikhwalithi yokuhlolwa.

2. Indlela ye-Isothermal Amplification Detection yesikhathi esifushane sokuhlola, futhi umphumela ungatholakala kungakapheli imizuzu engama-30.

3. Nge-Macro & Micro-Test Sample Release Reagent kanye ne-Macro & Micro-Test Automatic Nucleic Acid Extractor (HWTS-3006), kulula ukuyisebenzisa futhi ifanele izimo ezihlukahlukene.

4. Ukuzwela okuphezulu: i-LoD ye-CT ingu-400copies/mL;i-LoD ye-NG ingu-50 pcs/mL;i-LoD ye-UU ingu-400copies/mL;I-LoD ye-HSV2 ingamakhophi angu-400/mL.

5. Ukucaciswa okuphezulu: akukho ukuhlangana kabusha nezinye izinto ezithathelwanayo ezivamile ezihlobene (ezifana nogcunsula, izinsumpa zangasese, i-chancroid chancre, i-trichomoniasis, i-hepatitis B kanye nengculaza).

Izithenjwa:

[1] I-LOTTI F,MAGGI M.Ukungasebenzi kahle kwezocansi nokungazali [J].NatRev Urol,2018,15(5):287-307.

[2] CHOY JT,EISENBERG ML.Ukungazali kowesilisa njengefasitela lempilo[J].Fertil Steril,2018,110(5):810-814.

[3] ZHOU Z,ZHENG D,WU H,et al.I-Epidemiology of infertility e-China:ucwaningo olusekelwe kubantu abaningi[J].BJOG,2018,125(4):432-441.