Yini ebangela ukutheleleka kwe-C. Diff?
Ukutheleleka kwe-C.Diff kubangelwa yibhaktheriya eyaziwa ngokuthiI-Clostridioides difficile (C. difficile), okuvame ukuhlala emathunjini ngendlela engenangozi. Kodwa-ke, lapho ibhalansi yamabhaktheriya emathunjini iphazamiseka, ngokuvamile ukusetshenziswa kwama-antibiotic amaningi, i-C. difficile ingakhula kakhulu futhi ikhiqize ubuthi, okuholela ekuthelelekeni.
Leli gciwane likhona kuzo zombilii-toxigenkanye nezinhlobo ezingezona ezobuthi, kodwa izinhlobo zobuthi kuphela (ubuthi A no-B) ezibangela izifo. Zibangela ukuvuvukala ngokuphazamisa amangqamuzana e-epithelial emathunjini. I-Toxin A ngokuyinhloko iyi-enterotoxin elimaza ulwelwesi lwamathumbu, yandise ukungena kwamanzi, futhi idonse amangqamuzana omzimba akhipha ama-cytokine avuvukalayo. I-Toxin B, i-cytotoxin enamandla kakhulu, ihlasela i-actin cytoskeleton yamangqamuzana, okuholela ekujikelezeni kwamangqamuzana, ekuqhekekeni, futhi ekugcineni ekufeni kwamangqamuzana. Ndawonye, lobu buthi bubangela ukulimala kwezicubu kanye nokusabela okuqinile kwamasosha omzimba, okubonakala njenge-colitis, isifo sohudo, futhi ezimweni ezimbi kakhulu, i-pseudomembranous colitis—ukuvuvukala okukhulu kwekholoni.
KanjaniUmehluko we-Cukubhebhetheka?
I-C.Diff isakazeka kalula. Itholakala ezibhedlela, ivame ukutholakala kuma-ICU, ezandleni zabasebenzi besibhedlela, phansi nasezinsikeni zesibhedlela, kuma-thermometer kagesi, nakwezinye izinto zokwelapha...
Izici Zengozi Zokutheleleka Kwe-C. Diff
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●Ukulaliswa esibhedlela isikhathi eside; -
●Ukwelashwa ngama-antimicrobial; -
●Ama-ejenti e-Chemotherapy; -
●Ukuhlinzwa kwakamuva (izandla zesisu, i-gastric bypass, ukuhlinzwa kwe-colon); -
●Ukudla okunempilo kwamathumbu; -
●Ukutheleleka kwe-C. diff kwangaphambilini;
Izimpawu zokutheleleka kwe-C. Diff
Ukutheleleka kwe-C. diff kungaba yinto engakhululeki kakhulu. Iningi labantu liba nesifo sohudo esiqhubekayo kanye nokungakhululeki esiswini. Izimpawu ezivame kakhulu yilezi: isifo sohudo, ubuhlungu besisu, isicanucanu, ukulahlekelwa yisifiso sokudla, umkhuhlane.
Njengoba ukutheleleka kwe-C. diff kuba kubi kakhulu, kuzoba nokukhula kohlobo oluyinkimbinkimbi kakhulu lwe-C. diff olwaziwa ngokuthi i-colitis, i-pseudomembranous enteritis ngisho nokufa.
Ukuxilongwakwe-C. Diff Infection
Isiko Lamagciwane:Izwela kodwa ithatha isikhathi (izinsuku ezingu-2-5), ayikwazi ukuhlukanisa izinhlobo ze-toxigen kanye nezinga-toxigen;
Isiko Lobuthi:ikhomba izinhlobo ezinobuthi ezibangela izifo kodwa ezithatha isikhathi (izinsuku ezingu-3-5) futhi ezingazweli kakhulu;
Ukutholwa kwe-GDH:iyashesha (amahora angu-1-2) futhi iyabiza, ibucayi kakhulu kodwa ayikwazi ukuhlukanisa izinhlobo ze-toxigen kanye nezinga-toxigen;
Ukuhlolwa Kokungathathi hlangothi Kwe-Cell Cytotoxicity (CCNA):ithola ubuthi u-A no-B ngokuzwela okuphezulu kodwa kuthatha isikhathi (izinsuku ezi-2-3), futhi idinga izikhungo ezikhethekile nabasebenzi abaqeqeshiwe;
I-Toxin A/B ELISA: Ukuhlolwa okulula nokusheshayo (amahora angu-1-2) okunokuzwela okuphansi kanye nokungalungi okuvamile;
Ukuhlolwa Kokukhulisa I-Nucleic Acid (ama-NAAT): Iyashesha (1-3hr) futhi ibucayi kakhulu futhi iqondile, ithola izakhi zofuzo ezibangela ukukhiqizwa kobuthi;
Ngaphezu kwalokho, ukuhlolwa kwezithombe ukuhlola amathumbu, njenge-CT scans kanye ne-X-ray, kungasetshenziswa futhi ukusiza ekuxilongweni kwe-C. diff kanye nezinkinga ze-C. diff, njenge-colitis.
Ukwelashwa kokutheleleka kwe-C. Diff
Kunezindlela eziningi zokwelapha ezitholakalayoC. ukutheleleka kwe-diffNgezansi kunezinketho ezinhle kakhulu:
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●Ama-antibiotic asetshenziswa ngomlomo njenge-vancomycin, i-metronidazole noma i-fidaxomicin avame ukusetshenziswa njengoba umuthi ungadlula ohlelweni lokugaya ukudla futhi ufinyelele emathunjini lapho kuhlala khona amabhaktheriya e-C. diff. -
●I-metronidazole efakwa emthanjeni ingasetshenziswa ekwelapheni uma ukutheleleka kwe-C. diff kukubi kakhulu. -
●Ukufakelwa kwe-fecal microbiota kubonise ukusebenza kahle ekwelapheni ukutheleleka okuvamile kwe-C. diff kanye nokutheleleka okukhulu kwe-C. diff okungaphenduli kuma-antibiotic. -
●Ukuhlinzwa kungadingeka ezimweni ezinzima.
Isixazululo sokuxilonga esivela ku-MMT
Ukuphendula isidingo sokuthola ngokushesha nangokunembile i-C. difficile, sethula i-Nucleic Acid Detection Kit yethu entsha ye-Clostridium difficile toxin A/B gene, sinike amandla ochwepheshe bezempilo ukuthi benze ukuxilongwa kusenesikhathi nangokunembile kanye nokusekela ukulwa nokutheleleka okutholakale esibhedlela.
●Ukuzwela Okuphezulu: Ithola inani eliphansi njenge200 CFU/mL,;
●Ukuqondisa Okunembile: Ihlonza ngokunembile i-C. difficile toxin A/B gene, inciphisa imiphumela engamanga;
●Ukutholwa Kwe-Pathogen Okuqondile: Isebenzisa ukuhlolwa kwe-nucleic acid ukuhlonza ngqo izakhi zofuzo zobuthi, isungula indinganiso yegolide yokuxilonga.
●Ihambisana ngokugcwele neamathuluzi e-PCR ajwayelekile abhekana nama-lab amaningi;
Isampula-yempenduloIsixazululo ku-Macro & Micro-Test's AIO800 Mobile PCR Lab
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●Ukuzenzakalela Kwesampula-Ukuze-Impendulo – Layisha amashubhu esampula okuqala (1.5–12 mL) ngqo, kususa ukuphayipha ngesandla. Ukukhipha, ukukhulisa, kanye nokutholwa kwenziwa ngokuzenzakalela ngokuphelele, kunciphisa isikhathi sokusebenza kanye namaphutha omuntu. -
●Ukuvikelwa Kokungcola Okunezingqimba Eziyisishiyagalombili - Ukugeleza komoya okuqondiswayo, ukucindezela okungekuhle, ukuhlunga kwe-HEPA, ukubulala amagciwane kwe-UV, ukusabela okuvaliwe, kanye nezinye izindlela zokuphepha ezihlanganisiwe kuvikela abasebenzi futhi kuqinisekisa imiphumela ethembekile ngesikhathi sokuhlolwa kokuphuma okuphezulu.
Ukuze uthole imininingwane eyengeziwe:
https://www.mmtest.com/nucleic-acid-detection-kit-for-clostridium-difficile-toxin-ab-gene-fluorescence-pcr-product/
Contact us to learn more: marketing@mmtest.com;
Isikhathi sokuthunyelwe: Agasti-12-2025