Yini ebangela ukutheleleka kwe-C. Diff?
I-C.Diff infection idalwa yigciwane elaziwa ngokuthiI-Clostridioides difficile (C. difficile), ngokuvamile ehlala ngokungenabungozi emathunjini. Kodwa-ke, lapho ibhalansi yebhaktheriya yamathumbu iphazamiseka, ngokuvamile ukusetshenziswa kwama-antibiotic abanzi, i-C. difficile ingakhula ngokweqile futhi ikhiqize ubuthi, okuholela ekuthelelekeni.
Leli gciwane likhona kokubilii-toxickanye namafomu angewona ama-toxigenic, kodwa kuphela izinhlobo ze-toxigenic (ubuthi A no-B) obudala isifo. Baqala ukuvuvukala ngokuphazamisa amangqamuzana e-epithelial emathunjini. I-Toxin A ngokuyinhloko iyi-enterotoxin elimaza ulwelwesi lwamathumbu, ikhulisa ukungeneka, futhi ihehe amangqamuzana omzimba akhipha ama-cytokines avuvukalayo. I-Toxin B, i-cytotoxin enamandla kakhulu, iqondise ku-actin cytoskeleton yamaseli, okuholela ekuhlanganisweni kwamaseli, ukuhlukaniswa, futhi ekugcineni nokufa kwamangqamuzana. Ngokuhlangene, lobu buthi bubangela ukulimala kwezicubu kanye nokusabela okuqinile kokuzivikela komzimba, okubonakala njenge-colitis, isifo sohudo, futhi ezimeni ezinzima, i-pseudomembranous colitis-ukuvuvukala okukhulu kwekholoni.
Kwenza kanjaniC. Diffukubhebhetheka?
I-C.Diff isakazeka kalula. Ikhona ezibhedlela, ezivamise ukutholakala kuma-ICU, ezandleni zezisebenzi zasesibhedlela, ezitezi zesibhedlela nasezindaweni eziphathwayo, kumathemometha e-electronic, nakwezinye izisetshenziswa zezokwelapha...
Izingozi ze-C. Diff Infection
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●Ukulaliswa esibhedlela isikhathi eside; -
●Ukwelashwa ngama-antimicrobial; -
●ama-Chemotherapy agents; -
●Ukuhlinzwa kwakamuva (imikhono yesisu, i-gastric bypass, ukuhlinzwa kwekholoni); -
●Umsoco we-Naso-gastric; -
●Ngaphambili C. diff ukutheleleka;
Izimpawu ze-C. Diff infection
C. diff ukutheleleka kungase kungakhululeki kakhulu. Abantu abaningi banesifo sohudo esiqhubekayo nokungakhululeki esiswini. Izimpawu ezivame kakhulu yilezi: isifo sohudo, ubuhlungu besisu, isicanucanu, ukungakuthandi ukudla, imfiva.
Njengoba ukutheleleka kwe-C. diff kuba kubi kakhulu, kuzoba khona ukwakheka kohlobo oluyinkimbinkimbi ka-C. diff olwaziwa ngokuthi i-colitis, i-pseudomembranous enteritis ngisho nokufa.
Ukuxilongwaof C. Diff Infection
Amasiko Amagciwane:Izwela kodwa idla isikhathi (2-5days), ayikwazi ukuhlukanisa izinhlobo ze-toxigenic nezingezona i-toxigenic;
Isiko Lobuthi:ihlonza izinhlobo ze-toxigenic ezidala izifo kodwa ezidla isikhathi (izinsuku ezi-3-5) futhi zizwela kancane;
Ukutholwa kwe-GDH:iyashesha(1-2hrs) futhi iyonga, izwela kakhulu kodwa ayikwazi ukuhlukanisa izinhlobo ezinobuthi nezingezona ubuthi;
I-Cell Cytotoxicity Neutralization Assay (CCNA):ithola ubuthi obungu-A no-B obuzwela kakhulu kodwa budla isikhathi (izinsuku ezi-2-3), futhi idinga izikhungo ezikhethekile nabasebenzi abaqeqeshiwe;
Ubuthi A/B ELISA: Ukuhlolwa okulula nokushesha (1-2hrs) ngokuzwela okuphansi kanye nama-negative amanga avamile;
Izivivinyo ze-Nucleic Acid Amplification (NAATs): Ngokushesha (1-3hrs) futhi ebucayi kakhulu & ethize, ukuthola izakhi zofuzo ezibhekele ukukhiqizwa ubuthi;
Ukwengeza, ukuhlola kwesithombe sokuhlola amathumbu, okufana ne-CT scan nama-X-ray, kungase futhi kusetshenziswe ukusiza ekuxilongweni kwe-C. diff kanye nezinkinga ze-C. diff, njenge-colitis.
Ukwelashwa kwe-C. Diff infection
Izinketho zokwelashwa eziningi ziyatholakalaC. diff ukutheleleka. Ngezansi izinketho ezingcono kakhulu:
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●Imithi elwa namagciwane efana ne-vancomycin, i-metronidazole noma i-fidaxomicin ivame ukusetshenziswa njengoba umuthi ungadlula ohlelweni lokugaya ukudla futhi ufinyelele ekoloni lapho kuhlala khona amagciwane e-C. diff. -
●I-intravenous metronidazole ingase isetshenziselwe ukwelashwa uma isifo se-C. diff sinzima. -
●Ukufakelwa kwe-Fecal microbiota kubonise ukusebenza kahle ekwelapheni izifo ezivamile ze-C. diff kanye nezifo ezinzima ze-C. diff ezingaphenduli kuma-antibiotics. -
●Ukuhlinzwa kungase kudingeke ezimweni ezimbi kakhulu.
Isixazululo sokuxilonga esivela ku-MMT
Ukuze siphendule isidingo sokutholwa ngokushesha, nokunembile kwe-C. difficile, sethula Ikhithi yethu Yokutholwa Kwe-Nucleic Acid entsha yofuzo lwe-Clostridium difficile toxin A/B, sinikeza ochwepheshe bezempilo amandla okuxilonga kusenesikhathi nangokunembile futhi basekele ukulwa nezifo ezitholakala esibhedlela.
●Ukuzwela Okuphezulu: Ithola okuphansi njenge200 CFU/mL,;
●Ukukhomba Okunembile: Ihlonza ngokunembile isakhi sofuzo esingu-C. difficile A/B, sinciphise izici ezingamanga;
●Ukutholwa Kwe-Pathogen Okuqondile: Isebenzisa ukuhlolwa kwe-nucleic acid ukuze ikhombe ngokuqondile izakhi zofuzo ezinobuthi, isungula izinga eligolide lokuxilongwa.
●Ihambisana ngokugcweleamathuluzi e-PCR ajwayelekile akhuluma namalebhu amaningi;
Isampula-kuya-ImpenduloIsixazululo ku-Macro & Micro-Test's AIO800 Mobile PCR Lab
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●Ukuzenzakalela kwesampula-kuya-Impendulo - Layisha amashubhu esampula oqobo (1.5–12 mL) ngokuqondile, ukhiphe amapayipi okwenziwa ngesandla. Ukukhipha, ukukhulisa, nokutholwa kuzenzakalela ngokugcwele, kunciphisa ukusebenza ngesikhathi kanye nephutha lomuntu. -
●Ukuvikelwa Kokungcoliswa Kwezingqimba Eziyisishiyagalombili - Ukugeleza komoya okuqondile, ingcindezi engemihle, ukuhlunga kwe-HEPA, ukuvala inzalo kwe-UV, ukusabela okuvalwe uphawu, nezinye izivikelo ezihlanganisiwe zivikela abasebenzi futhi ziqinisekise imiphumela ethembekile ngesikhathi sokuhlolwa komphumela ophezulu.
Ukuze uthole imininingwane eyengeziwe:
https://www.mmtest.com/nucleic-acid-detection-kit-for-clostridium-difficile-toxin-ab-gene-fluorescence-pcr-product/
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Isikhathi sokuthumela: Aug-12-2025