Isikhunta Esivamile, Imbangela Eyinhloko Yesifo Se-Vaginitis Nezifo Zesikhunta Zamaphaphu – Candida Albicans

Ukubaluleka Kokutholwa

I-fungus candidiasis (eyaziwa nangokuthi ukutheleleka kwe-candida) ivame kakhulu. Kunezinhlobo eziningi ze-Candida futhiizinhlobo ezingaphezu kuka-200 ze-Candida bebelokhuokutholakale kuze kube manje.Ama-Candida albicans (CA) iyona ebangela izifo kakhulu, okubala cishe ama-70% azo zonke izifo ezithathelwanayo.I-CA, eyaziwa nangokuthi i-Candida emhlophe, ivame ukuba nezibungu esikhumbeni somuntu, emlonyeni, endleleni yokugaya ukudla, esithweni sangasese sowesifazane, njll. Uma ukusebenza komzimba womuntu kungajwayelekile noma izitshalo ezijwayelekile zingalingani, i-CA kungenzeka kubangela ukutheleleka kwesistimu yomzimba, ukutheleleka kwesitho sangasese sowesifazane, ukutheleleka kwendlela yokuphefumula engezansi, njll.

Ukuvuvukala kwabesifazane:Cishe ama-75% abesifazane babhekana ne-vulvovaginal candidiasis (VVC) okungenani kanye empilweni yabo, kanti ingxenye yabo izophinde ivele. Ngaphezu kwezimpawu zomzimba ezibuhlungu njengokulunywa nokushiswa yi-vulvovaginal, amacala amakhulu angabangela ukungaphumuli, okusobala kakhulu ebusuku, futhi kuthinta kakhulu imizwa yesiguli kanye nokusebenza kwengqondo. I-VVC ayinazo izimpawu ezithile zezokwelapha, futhi ukuhlolwa kwelabhorethri kuyisihluthulelo sokuxilongwa.

Ukutheleleka kwesikhunta se-pulmonary:CA ukutheleleka kuyimbangela ebalulekile yokufa ngenxa yokutheleleka esibhedlela futhi kubalwa cishe u-40%iziguli ezigula kakhulu e-ICU. Ucwaningo olubheka emuva olugxile ezikhungweni eziningi lwesifo sefungal samaphaphu eShayina kusukela ngo-1998 kuya ku-2007 luthole ukuthi i-pulmonary candidiasis yayibalelwa ku-34.2%, okukhona kuwoCA kubhekwa njengezimbangela ezingama-65% ze-pulmonary candidiasis.A Ukutheleleka akunazo izimpawu ezivamile zomtholampilo futhi akunazo izimpawu ezicacile ekubonakaleni kwezithombe, okwenza kube nzima ukuxilongwa kusenesikhathi. Isivumelwano sochwepheshe mayelana nokuxilongwa nokwelashwa kwesifo se-fungal samaphaphu sincoma ukusetshenziswa kwamasampula e-sputum afanelekile aqoqwe ngokujulile, okuqinisa ukuhlolwa kwe-molecular biological, kanye nokunikeza izinhlelo zokwelapha i-fungus ezifanele.

Izinhlobo Zesampula

 

Isixazululo Sokuthola

Izici zomkhiqizo

Ukusebenza kahle：Ukukhulisa i-isothermal ukuze kukhuliswe kalula futhi kube nomphumela kungakapheli imizuzu engama-30;

Ukucaciswa okuphezulu: Si-pecific primer kanye ne-probe (rProbe)yakhelweezindaweni ezilondolozwe kakhulu ze-CAngesistimu evaliwe ngokuphelele ukuthola ngqo i-CA DNA kumasampula. Akukho ukuhlangana nezinye izifo ezibangelwa ukutheleleka kwe-urogenital tract;

Ukuzwela okuphezulu: I-LoD kweyi-10² amabhaktheriya/mL;

I-QC Esebenzayo: Ukubhekisela kwangaphakathi kwangaphandle kwe-reagent yokulawula kanye nekhwalithi yokusebenza futhi kugwenywe izinto ezingezinhle ezingamanga;

Imiphumela enembile: amacala ayi-1,000 e-multicenterukuhlolwa kwemitholampilo nge-rizinga lokuthobela umthetho elipheleleof 99.7%;

Ukusabalala okubanzi kwama-serotypes: Zonke izinhlobo zama-serotypes e-Candida albicans A, B, Cimboziwe ngeimiphumela ehambisanayouma kuqhathaniswaukutholwa kokulandelana;

Ama-reagent avulekile: Iyahambisana ne-PCR ejwayelekile yamanjeama-systama-em.

Ulwazi Lomkhiqizo

Ikhodi Yomkhiqizo	Igama Lomkhiqizo	Imininingwane	Inombolo Yesitifiketi
I-HWTS-FG005	Ikhithi Yokuthola I-Nucleic Acid esekelwe ku-Enzymatic Probe Isothermal Amplification (EPIA) yama-Candida Albicans	5Ukuhlolwa/ikhithi engu-0
I-HWTS-EQ008	I-Amp elulaUhlelo Lokuthola Isothermal Lwe-Fluorescence Yesikhathi Sangempela	I-HWTS-1600P 4 iziteshi ze-fluorescence	I-NMPA2023322059
I-HWTS-EQ009		Ama-HWTS-1600s 2iziteshi ze-fluorescence