Ngokombiko wakamuva womdlavuza womhlaba wonke, umdlavuza wamaphaphu usaqhubeka nokuba yimbangela ehamba phambili yokufa kwabantu okuhlobene nomdlavuza emhlabeni wonke, okubalelwa ku-18.7% wabo bonke abantu abashonile ngo-2022. Iningi lalezi zigameko umdlavuza we-Non-Small Cell Lung Cancer (NSCLC). Ngenkathi ukuthembela komlando ku-chemotherapy ngezifo ezithuthukile kunikeza inzuzo elinganiselwe, i-paradigm isishintshile ngokuyisisekelo.
Ukutholwa kwama-biomarker angukhiye, njenge-EGFR, ALK, kanye ne-ROS1, kuguqule ukwelashwa, kukususe endleleni elingana konke kuya esu elinembayo eliqondise kubashayeli bofuzo abahlukile bomdlavuza wesiguli ngasinye.
Kodwa-ke, impumelelo yalezi zindlela zokwelashwa eziguquguqukayo incike ngokuphelele ekuhlolweni kofuzo okunembile nokuthembekile ukuze kuhlonzwe okuhloswe ngakho isiguli esifanele.
Ama-Biomarker Abalulekile: EGFR, ALK, ROS1, kanye ne-KRAS
Ama-biomarker amane ame njengezinsika ekuxilongweni kwamangqamuzana e-NSCLC, eqondisa izinqumo zokwelashwa zomugqa wokuqala:
-I-EGFR:Uguquko olusebenza kakhulu, ikakhulukazi kubantu base-Asia, abesifazane, nabangabhemi. I-EGFR tyrosine kinase inhibitors (TKIs) njenge-Osimertinib ibe ngcono kakhulu imiphumela yesiguli.
-I-ALK:"Ukuguqulwa kwedayimane," okukhona ku-5-8% wamacala e-NSCLC. Iziguli ezine-ALK fusion-positive zivame ukuphendula ngokujulile kuma-ALK inhibitors, zithole ukuphila isikhathi eside.
-I-ROS1:Ukwabelana ngokufana kwesakhiwo ne-ALK, leli "gugu elingavamile" lenzeka ku-1-2% yeziguli ze-NSCLC. Izindlela zokwelapha eziqondisiwe ezisebenzayo ziyatholakala, okwenza ukutholakala kwayo kube bucayi.
-I-KRAS:Ngokomlando kwakubhekwa “njengokungenakulungiseka,” ukuguqulwa kwe-KRAS kuvamile. Ukugunyazwa kwakamuva kwe-KRAS G12C inhibitors kuguqule le biomarker isuka kumaka ebikezela ukuthi iyini okuqondiwe okungenziwa, kushintsha ukunakekelwa kwalesi siqeshana sesiguli.
Iphothifoliyo ye-MMT: Eyakhelwe Ukuqiniseka Kokuxilongwa
Ukuze kuhlangatshezwane nesidingo esiphuthumayo sokuhlonza okunembile kwe-biomarker, i-MMT inikeza iphothifoliyo ye-CE-IVD emakwe isikhathi sangempela.Amakhithi okuthola i-PCR, ngayinye yakhelwe ngobuchwepheshe obusezingeni eliphezulu ukuze kuqinisekiswe ukuzethemba kokuxilonga.
1. Ikhithi Yokuthola Ukuguquka Kwe-EGFR
-Ubuchwepheshe be-ARMS obuthuthukisiwe:Izithuthukisi zobunikazi zikhuphula ukukhuliswa okuqondene nokuguquguquka.
-Ukuthuthukisa i-Enzymatic:Ama-endonuclease akhawulelwe agaya ingemuva le-genomic yohlobo lwasendle, ethuthukisa ukulandelana kwe-mutant nokuthuthukisa ukulungiswa.
-Ukuvinjwa kwezinga lokushisa:Isinyathelo esicacisiwe sokushisa sinciphisa ukuqala okungaqondile, siphinde sinciphise ingemuva lohlobo lwasendle.
-Izinzuzo Eziyinhloko:Ukuzwela okungafani kuya phansi1%imvamisa ye-mutant allele, ukunemba okuhle kakhulu ngezilawuli zangaphakathi kanye ne-UNG enzyme, kanye nesikhathi sokushintsha ngokushesha cishe cisheImizuzu eyi-120.
- Iyahambisanakokubili amasampula ezicubu kanye ne-liquid biopsy.
- Ikhithi yokuthola i-MMT EML4-ALK Fusion
- Ukuzwela Okuphezulu:Ithola ngokunembile ukuguqulwa kwe-fusion enomkhawulo ophansi wokutholwa kwamakhophi angu-20/ukusabela.
-Ukunemba Okuhle Kakhulu:Ihlanganisa izindinganiso zangaphakathi zokulawula inqubo kanye ne-enzyme ye-UNG ukuvimbela ukungcoliswa kwe-carryover, ngokuphumelelayo ukugwema ukuhle nokubi okungamanga.
-Kulula futhi Kuyashesha:Ifaka ukusebenza okulula, kweshubhu elivaliwe eliqedwe cishe imizuzu eyi-120.
-Ukuhambisana Kwezinsimbi:Ivumelana nezimo ezihlukahlukeneizinsimbi ze-PCR zesikhathi sangempela, enikeza ukuguquguquka kwanoma yikuphi ukusethwa kwelabhorethri.
- Ikhithi yokutholwa kwe-MMT ROS1 Fusion
Ukuzwela Okuphezulu:Ibonisa ukusebenza okukhethekile ngokuthola ngokuthembekile amakhophi aphansi angama-20/ukusabela kokuhlosiwe kokuhlanganisa.
Ukunemba Okuhle Kakhulu:Ukusetshenziswa kwezilawuli zekhwalithi zangaphakathi kanye ne-enzyme ye-UNG kuqinisekisa ukwethembeka kwayo yonke imiphumela, kunciphisa ubungozi bokubika amaphutha.
Kulula futhi Kuyashesha:Njengesistimu yeshubhu evaliwe, ayidingi izinyathelo eziyinkimbinkimbi zangemuva kokukhulisa. Imiphumela ehlosiwe nethembekile itholakala emaminithini angaba ngu-120.
Ukuhambisana Kwezinsimbi:Idizayinelwe ukusebenzisana okubanzi nohlu lwemishini ye-PCR evamile, esiza ukuhlanganiswa okulula kokugeleza komsebenzi okukhona ngelebhu.
- Ikhithi Yokuthola Ukuguquka Kwe-MMT KRAS
- Ubuchwepheshe be-ARMS obuthuthukisiwe, buqiniswe Ukucebisa Kwe-Enzymatic kanye Nokuvinjwa Kwezinga lokushisa.
- Ukuthuthukisa i-Enzymatic:Isebenzisa ama-endonuclease okukhawulela ukugaya ngokukhetha ingemuva le-genomic yohlobo lwasendle, ngaleyo ndlela inothise ukulandelana kwe-mutant futhi ithuthukise ngokuphawulekayo ukutholwa.
-Ukuvinjwa kwezinga lokushisa:Sethula isinyathelo esithile sezinga lokushisa ukuze sidale ukungafani phakathi kwama-primer aqondene ne-mutant kanye nezifanekiso zohlobo lwasendle, siqhubeke sinciphisa ingemuva nokuthuthukisa ukucaciswa.
- Ukuzwela Okuphezulu:Ifinyelela ukuzwela kokutholwa okungu-1% kuma-alleles aguquguqukayo, iqinisekisa ukuhlonza ukuguqulwa kwenani eliphansi.
-Ukunemba Okuhle Kakhulu:Izindinganiso zangaphakathi ezihlanganisiwe kanye nokuvikela kwe-enzyme ye-UNG emiphumeleni engalungile nengalungile.
-Iphaneli ephelele:Ilungiselelwe kahle ukusiza ukutholwa kokuguqulwa kwe-KRAS okuyisishiyagalombili okuhlukile kumashubhu wokusabela amabili nje.
- Kulula futhi Kuyashesha:Iletha imiphumela ehlosiwe nethembekile cishe emaminithini angu-120.
- Ukuhambisana Kwezinsimbi:Ijwayelana kalula nezisetshenziswa ezihlukahlukene ze-PCR, ihlinzeka ngokuguquguquka kwamalabhorethri omtholampilo.
Kungani Khetha Isixazululo se-MMT NSCLC?
Okuphelele: Isuite ephelele yama-biomarker amane e-NSCLC abaluleke kakhulu.
Okuphezulu Ngokwezobuchwepheshe: Izithuthukisi Zobunikazi (Ukucebisa Nge-Enzymatic, Ukuvinjwa Kwezinga lokushisa) kuqinisekisa ukucaciswa okuphezulu nokuzwela lapho kubaluleke kakhulu.
Kuyashesha futhi Kuyasebenza: Iphrothokholi Efanayo ~ yemizuzu eyi-120 kuyo yonke iphothifoliyo isheshisa ukwelashwa kwesikhathi.
Kuyavumelana nezimo futhi kuyafinyeleleka: Ihambisana nenhlobo ebanzi yesampula namathuluzi e-PCR ajwayelekile, inciphisa imigoqo yokusetshenziswa.
Isiphetho
Esikhathini se-oncology enembile, ukuxilonga kwamangqamuzana kuyikhampasi eqondisa ukuzulazula kokwelapha. Izinsiza zokuhlonza ezithuthukisiwe ze-MMT zinikeza odokotela amandla ukuze bakwazi ukwenza imephu ngokuzethemba isimo sofuzo se-NSCLC yesiguli, bavule amandla okusindisa impilo ezindlela zokwelapha eziqondisiwe.
Contact to learn more: marketing@mmtest.com
Isikhathi sokuthumela: Nov-05-2025