Ngokusho kombiko wakamuva womdlavuza womhlaba wonke, umdlavuza wamaphaphu uyaqhubeka nokuba yimbangela ehamba phambili yokufa okuhlobene nomdlavuza emhlabeni jikelele, okubalwa u-18.7% wabo bonke abafa ngo-2022. Iningi lala macala yi-Non-Small Cell Lung Cancer (NSCLC). Nakuba ukuthembela komlando ku-chemotherapy yezifo ezithuthukile kunikeze izinzuzo ezilinganiselwe, umbono usushintshile kakhulu.
Ukutholakala kwama-biomarker abalulekile, njenge-EGFR, i-ALK, ne-ROS1, kushintshe indlela yokwelapha, kuyisusa endleleni eyodwa efanelana nakho konke kuya endleleni enembile ehlose abashayeli bezakhi zofuzo abahlukile bomdlavuza wesiguli ngasinye.
Kodwa-ke, impumelelo yalezi zindlela zokwelapha ezintsha incike ngokuphelele ekuhlolweni kwezakhi zofuzo okunembile nokuthembekile ukuze kutholakale umgomo ofanele wesiguli esifanele.
Ama-Biomarker Abalulekile: i-EGFR, i-ALK, i-ROS1, kanye ne-KRAS
Ama-biomarker amane ami njengezinsika ekuxilongweni kwama-molecule e-NSCLC, eqondisa izinqumo zokwelapha zomugqa wokuqala:
-I-EGFR:Uguquko oluvame kakhulu olusebenzayo, ikakhulukazi kubantu base-Asia, abesifazane, kanye nabangabhemi. Ama-EGFR tyrosine kinase inhibitors (TKIs) afana ne-Osimertinib athuthukise kakhulu imiphumela yeziguli.
-I-ALK:"Ukuguqulwa kwedayimane," kuvela ku-5-8% wezimo ze-NSCLC. Iziguli ezine-ALK fusion-positive zivame ukusabela kakhulu kuma-ALK inhibitors, okufeza ukusinda isikhathi eside.
-I-ROS1:Njengoba ifana ngesakhiwo ne-ALK, le "gugu elingavamile" livela ku-1-2% weziguli ze-NSCLC. Izindlela zokwelapha eziqondile ezisebenzayo ziyatholakala, okwenza ukutholakala kwayo kube yinto ebalulekile.
-I-KRAS:Ukuguqulwa kwe-KRAS okwakubhekwa “njengokungasebenzisi imithi” kuvamile. Ukuvunyelwa kwamuva nje kwama-KRAS G12C inhibitors kushintshe le biomarker kusuka kuphawu lokubikezela kwaba yithagethi engenzeka, kwaguqula ukunakekelwa kwalesi sigaba seziguli.
Iphothifoliyo ye-MMT: Yakhelwe Ukuzethemba Kokuxilonga
Ukuze kuhlangatshezwane nesidingo esiphuthumayo sokuhlonza i-biomarker enembile, i-MMT inikeza iphothifoliyo ye-CE-IVD ephawulwe ngesikhathi sangempelaAmakhithi okuthola i-PCR, ngayinye yaklanywa ngobuchwepheshe obusezingeni eliphezulu ukuqinisekisa ukuzethemba kokuxilonga.
1. Ikhithi Yokuthola Ukuguquka Kwe-EGFR
-Ubuchwepheshe be-ARMS obuthuthukisiwe:Izithuthukisi zobunikazi zandisa ukwanda okuqondene nokuguqulwa kwezakhi zofuzo.
-Ukucebisa nge-Enzymatic:Ama-endonuclease okukhawulela agaya isizinda se-genomic sohlobo lwasendle, athuthukise ukulandelana kwe-mutant futhi athuthukise isinqumo.
-Ukuvimba Izinga Lokushisa:Isinyathelo esithile sokushisa sinciphisa i-priming engacacile, sinciphise kakhulu isizinda se-wild-type.
-Izinzuzo Eziyinhloko:Ukuzwela okungalingani kuye phansi1%imvamisa ye-allele eguquliwe, ukunemba okuhle kakhulu ngokulawula kwangaphakathi kanye ne-enzyme ye-UNG, kanye nesikhathi sokushintsha okusheshayo cisheImizuzu eyi-120.
- Iyahambisana nekokubili amasampula e-biopsy yezicubu kanye noketshezi.
- Ikhithi Yokuthola I-MMT EML4-ALK Fusion
- Ukuzwela Okuphezulu:Ithola ngokunembile ukuguqulwa kwe-fusion ngomkhawulo ophansi wokutholwa kwamakhophi angu-20/ukusabela.
-Ukunemba Okuhle Kakhulu:Ihlanganisa amazinga angaphakathi okulawula inqubo kanye ne-enzyme ye-UNG ukuvimbela ukungcola okuqhubekayo, igwema ngempumelelo okuhle nokubi okungamanga.
-Kulula Futhi Kuyashesha:Isebenza ngendlela elula, evaliwe, futhi eqediwe cishe ngemizuzu eyi-120.
-Ukuhambisana Kwezinsimbi:Ivumelana nezimo ezahlukahlukene ezivamileamathuluzi e-PCR esikhathi sangempela, enikeza ukuguquguquka kwanoma yikuphi ukusethwa kwelabhorethri.
- Ikhithi Yokuthola I-MMT ROS1 Fusion
Ukuzwela Okuphezulu:Ibonisa ukusebenza okuhle kakhulu ngokuthola ngokuthembekile amakhophi angaphansi kwangu-20/ukusabela kwama-fusion target.
Ukunemba Okuhle Kakhulu:Ukusetshenziswa kwezilawuli zekhwalithi yangaphakathi kanye ne-enzyme ye-UNG kuqinisekisa ukuthembeka kwayo yonke imiphumela, kunciphisa ingozi yokubika amaphutha.
Kulula Futhi Kuyashesha:Njengesistimu yepayipi elivaliwe, ayidingi zinyathelo eziyinkimbinkimbi zokukhulisa. Imiphumela eqondile nethembekile itholakala cishe ngemizuzu eyi-120.
Ukuhambisana Kwezinsimbi:Yakhelwe ukuhambisana okubanzi nohlu lwemishini ye-PCR evamile, okwenza kube lula ukuhlanganiswa emisebenzini yelebhu ekhona.
- Ikhithi Yokuthola Ukuguquka Kwe-MMT KRAS
- Ubuchwepheshe be-ARMS obuthuthukisiwe, obuqiniswe yi-Enzymatic Enrichment kanye ne-Temperature Blocking.
- Ukucebisa nge-Enzymatic:Isebenzisa ama-endonuclease okukhawulela ukugaya ngokukhetha isizinda se-genomic sohlobo lwasendle, ngaleyo ndlela ithuthukise ukulandelana kwe-mutant futhi ithuthukise kakhulu isinqumo sokutholwa.
-Ukuvimba Izinga Lokushisa:Kwethula isinyathelo esithile sokushisa ukuze kubangele ukungalingani phakathi kwama-primer athile aguquliwe kanye namathempulethi e-wild-type, kunciphisa isizinda futhi kuthuthukise ukucaciswa.
- Ukuzwela Okuphezulu:Ifinyelela ukuzwela kokutholwa okungu-1% kuma-alleles aguquliwe, iqinisekisa ukuhlonza izinguquko ezincane.
-Ukunemba Okuhle Kakhulu:Izindinganiso zangaphakathi ezihlanganisiwe kanye ne-enzyme ye-UNG zivikela emiphumeleni engamanga emihle nemibi.
-Iphaneli Ephelele:Kuhlelwe kahle ukuze kube lula ukuthola izinguquko eziyisishiyagalombili ezihlukile ze-KRAS kumashubhu amabili okusabela.
- Kulula Futhi Kuyashesha:Iletha imiphumela eqondile nethembekile cishe ngemizuzu eyi-120.
- Ukuhambisana Kwezinsimbi:Ivumelana kalula nezinsimbi ezahlukahlukene ze-PCR, inikeza ukuguquguquka kwezindawo zokucwaninga zemitholampilo.
Kungani Kufanele Ukhethe Isixazululo se-MMT NSCLC?
Okuphelele: Isethi ephelele yama-biomarker amane abaluleke kakhulu e-NSCLC.
Okuphakeme Ngobuchwepheshe: Ukuthuthukiswa kobunikazi (Ukucebisa nge-Enzymatic, Ukuvinjelwa Kwezinga Lokushisa) kuqinisekisa ukucaciswa okuphezulu kanye nokuzwela lapho kubaluleke kakhulu.
Kuyashesha Futhi Kusebenza Kahle: Iphrothokholi efanayo yemizuzu engu-120 kuyo yonke iphothifoliyo isheshisa isikhathi sokwelashwa.
Iyaguquguquka futhi ifinyeleleke: Iyahambisana nezinhlobo eziningi zamasampula kanye namathuluzi e-PCR ajwayelekile, okunciphisa izithiyo zokusebenzisa.
Isiphetho
Esikhathini sokuhlolwa kwe-oncology okunembile, ukuxilongwa kwama-molecular kuyikhampasi eqondisa ukuzulazula kokwelapha. Ama-kit okuthola athuthukile e-MMT anika amandla odokotela ukuthi bahlele ngokuzethemba isimo sezakhi zofuzo se-NSCLC yesiguli, bavule amandla okusindisa impilo ezindlela zokwelapha eziqondiwe.
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Isikhathi sokuthunyelwe: Novemba-05-2025