Ukumelana namagciwane (i-AMR) sekungenye yezinsongo ezinkulu kakhulu empilweni yomphakathi kuleli khulu leminyaka, okubangela ngqo ukufa kwabantu abangaphezu kwezigidi ezingu-1.27 minyaka yonke futhi okubangela ukufa okwengeziwe cishe kwezigidi ezi-5—le nkinga yezempilo yomhlaba wonke ephuthumayo idinga isinyathelo sethu esisheshayo.
Kuleli Sonto Lokuqwashisa Nge-AMR Lomhlaba (Novemba 18-24), abaholi bezempilo bomhlaba wonke bahlangana esicelweni sabo:"Thatha Isinyathelo Manje: Vikela Isikhathi Sethu Samanje, Vikela Ikusasa Lethu."Lesi sihloko sigcizelela ukuphuthuma kokubhekana ne-AMR, okudinga imizamo ehlanganisiwe kuzo zonke imikhakha yezempilo yabantu, impilo yezilwane kanye nezemvelo.
Usongo lwe-AMR ludlula imingcele yezwe kanye nezindawo zokunakekelwa kwempilo. Ngokusho kocwaningo lwakamuva lwe-Lancet, ngaphandle kokungenelela okusebenzayo ngokumelene ne-AMR,ukufa kwabantu emhlabeni wonke jikelele kungafinyelela ezigidini ezingu-39 ngo-2050, kuyilapho izindleko zonyaka zokwelapha izifo ezingamelani nemithi kulindeleke ukuthi zikhuphuke zisuka ku-$66 billion zamanje ziye ku-$66 billion.AmaRandi ayizigidigidi eziyi-159.
Inkinga ye-AMR: Iqiniso Elibi Elingemuva Kwezinombolo
Ukumelana nama-antimicrobial (AMR) kwenzeka lapho ama-microorganism—amabhaktheriya, ama-virus, ama-parasite, kanye ne-fungi—engasaphenduli emithini evamile yokulwa namagciwane. Le nkinga yezempilo yomhlaba wonke isifinyelele amazinga ashaqisayo:
-Njalo ngemizuzu emi-5, Umuntu oyedwa uyafa ngenxa yokutheleleka okumelana nama-antibiotic
-Ngu2050, i-AMR inganciphisa i-GDP yomhlaba wonke ngo-3.8%
-Amazwe angu-96%(abangu-186 sebebonke) bahlanganyele ocwaningweni lokulandelela i-AMR lomhlaba wonke lwango-2024, okubonisa ukuqashelwa kabanzi kwalolu songo.
-Ezigumbini zokunakekelwa okujulile kwezinye izindawo,ngaphezu kwama-50% amabhaktheriya ahlukanisiwebonisa ukumelana okungenani nemithi eyodwa yokulwa namagciwane
Indlela Ama-antibiotic Ahluleka Ngayo: Izindlela Zokuzivikela Zamagciwane
Ama-antibiotic asebenza ngokugxila ezinqubweni ezibalulekile zamagciwane:
-Ukwenziwa Kodonga LweseliAma-penicillin aphazamisa izindonga zamaseli ebhaktheriya, okubangela ukuqhekeka nokufa kwamagciwane
-Ukukhiqizwa Kwamaprotheni: Ama-tetracycline nama-macrolide avimba ama-ribosome amabhaktheriya, amise ukwakheka kwamaprotheni
-Ukuphindaphinda kwe-DNA/RNA: Ama-fluoroquinolones avimbela ama-enzyme adingekayo ekuphindaphindweni kwe-DNA yamagciwane
-Ubuqotho be-Membrane YeseliAma-polymyxin alimaza ulwelwesi lwamangqamuzana ebhaktheriya, okuholela ekufeni kwamangqamuzana
-Izindlela Zokuguqula UmzimbaAma-Sulfonamides avimba izinqubo ezibalulekile zamabhaktheriya njengokwenziwa kwe-folic acid
Kodwa-ke, ngokukhetha kwemvelo kanye nokuguquka kwezakhi zofuzo, amabhaktheriya athuthukisa izindlela eziningi zokumelana nama-antibiotic, okuhlanganisa ukukhiqiza ama-enzyme angasebenzi, ukushintsha imigomo yemithi, ukunciphisa ukuqongelela kwemithi, kanye nokwenza ama-biofilms.
I-Carbapenemase: “Isikhali Esikhulu” Enkingeni Ye-AMR
Phakathi kwezindlela ezahlukene zokumelana, ukukhiqizwa kweama-carbapenemakuyakhathaza kakhulu. Lawa ma-enzyme asebenzisa ama-antibhayoloji e-carbapenem—ngokuvamile abhekwa njengemithi “yomugqa wokugcina”. Ama-Carbapenema asebenza njengezikhali “ezinhle kakhulu” zamagciwane, abhidliza ama-antibiotic ngaphambi kokuba angene emangqamuzaneni ebhaktheriya. Amabhaktheriya athwala la ma-enzyme—njengeI-Klebsiella i-pneumoniaefuthiI-Acinetobacter baumannii—ingasinda futhi yande ngisho noma itholakele kuma-antibiotic anamandla kakhulu.
Okushaqisayo nakakhulu ukuthi izakhi zofuzo ezifaka ama-carbapenema zitholakala ezintweni zofuzo ezihambayo ezingadlula phakathi kwezinhlobo ezahlukene zamagciwane,ukusheshisa ukusabalala komhlaba wonke kwamagciwane amelana nemithi eminingi.
Ukuxilongwas: Umugqa Wokuqala Wokuzivikela Ekulawulweni kwe-AMR
Ukuxilongwa okunembile nokusheshayo kubalulekile ekulweni ne-AMR. Ukuhlonza ngesikhathi amabhaktheriya amelana namagciwane kungenza okulandelayo:
-Qondisa ukwelashwa okunembile, ugweme ukusetshenziswa okungekuhle kwama-antibiotic
-Sebenzisa izindlela zokulawula ukutheleleka ukuze uvimbele ukudluliswa kwamagciwane amelana nokumelana
-Qapha izitayela zokumelana ukuze uqondise izinqumo zezempilo zomphakathi
Izixazululo Zethu: Amathuluzi Antsha Okulwa Okuqondile kwe-AMR
Ukuze kuxazululwe inselele ekhulayo ye-AMR, i-Macro & Micro-Test ithuthukise amakhithi amathathu okuthola i-carbapenemase amasha ahlangabezana nezidingo ezahlukene zezokwelapha, esiza abahlinzeki bezempilo ukuthi babone ngokushesha nangokunembile amagciwane amelana namagciwane ukuqinisekisa ukungenelela okufika ngesikhathi kanye nemiphumela ethuthukisiwe yeziguli.
1. Ikhithi Yokuthola I-Carbapenase (i-Colloidal Gold)
Isebenzisa ubuchwepheshe be-colloidal gold ukuthola i-carbapenemase ngokushesha nangokuthembekile. Ifanelekela izibhedlela, imitholampilo, ngisho nokusetshenziswa ekhaya, okwenza inqubo yokuxilonga ibe lula ngokunemba okuphezulu.
Izinzuzo Eziyinhloko:
-Ukutholwa Okuphelele: Ngesikhathi esifanayo ihlonza izakhi zofuzo ezinhlanu zokumelana—i-NDM, i-KPC, i-OXA-48, i-IMP, kanye ne-VIM
-Imiphumela Esheshayo: Inikeza imiphumela ngaphakathiimizuzu eyi-15, ngokushesha okukhulu kunezindlela zendabuko (izinsuku ezingu-1-2)
-Ukusebenza okulula: Akukho mishini eyinkimbinkimbi noma ukuqeqeshwa okukhethekile okudingekayo, okufanelekela izilungiselelo ezahlukahlukene
-Ukunemba Okuphezulu: Ukuzwela okungu-95% ngaphandle kwemiphumela engamanga evela kumagciwane avamile njenge-Klebsiella pneumoniae noma i-Pseudomonas aeruginosa
2. Ikhithi Yokuthola Izakhi Zofuzo Zokumelana Ne-Carbapenem (i-Fluorescence PCR)
Yakhelwe ukuhlaziywa okujulile kwezakhi zofuzo zokumelana ne-carbapenem. Ilungele ukubhekwa okuphelele emalabhorethri emitholampilo, ihlinzeka ngokutholakala okunembile kwezakhi zofuzo eziningi zokumelana ne-carbapenem.
Izinzuzo Eziyinhloko:
-Ukusampula Okuguquguqukayo: Ukutholwa okuqondile okuvela ku-amakholoni ahlanzekile, isikhwehlela, noma ama-rectal swabs—akukho ukukhuliswakuyadingeka
-Ukwehliswa Kwezindleko: Ithola izakhi zofuzo eziyisithupha ezibalulekile zokumelana (i-NDM, i-KPC, i-OXA-48, i-OXA-23) IMP, kanye ne-VIM esivivinyweni esisodwa, isusa ukuhlolwa okungafuneki.
-Ukuzwela Okuphezulu Nokucacile: Umkhawulo wokutholwa ophansi njengo-1000 CFU/mL, akukho ukuhlangana kabusha nezinye izakhi zofuzo zokumelana njenge-CTX, i-mecA, i-SME, i-SHV, ne-TEM
-Ukuhambisana Okubanzi: IyahambisanaIsampula-yempenduloI-AIO 800 i-POCT yama-molecule ezenzakalelayo ngokugcwele kanye nezinsimbi ze-PCR ezijwayelekile
3. I-Klebsiella pneumoniae, i-Acinetobacter baumannii, i-Pseudomonas aeruginosa kanye ne-Resistance Genes Multiplex Detection Kit (i-Fluorescence PCR)
Le khithi ihlanganisa ukuhlonza amagciwane kanye nezindlela zokumelana ezihambisanayo enkambisweni eyodwa elula yokuxilonga okuphumelelayo.
Izinzuzo Eziyinhloko:
-Ukutholwa Okuphelele: Ikhomba ngesikhathi esisodwaizifo ezintathu eziyinhloko zamagciwane—I-Klebsiella pneumoniae, i-Acinetobacter baumannii, kanye ne-Pseudomonas aeruginosa—futhi ithola izakhi zofuzo ezine ezibalulekile ze-carbapenemase (i-KPC, i-NDM, i-OXA48, kanye ne-IMP) ekuhlolweni okukodwa.
-Ukuzwela Okuphezulu: Iyakwazi ukuthola i-DNA yebhaktheriya ngamanani aphansi njenge-1000 CFU/mL
-Isekela Isinqumo Sezokwelapha: Kwenza kube lula ukukhetha ukwelashwa okusebenzayo okulwa namagciwane ngokuhlonza kusenesikhathi izinhlobo ezimelana namagciwane
-Ukuhambisana Okubanzi: IyahambisanaIsampula-yempenduloI-AIO 800 i-POCT yama-molecule ezenzakalelayo ngokugcwele kanye nezinsimbi ze-PCR ezijwayelekile
Lawa makhithi okuthola ahlinzeka ochwepheshe bezempilo ngamathuluzi okubhekana ne-AMR emazingeni ahlukene—kusukela ekuhlolweni okusheshayo kwendawo yokunakekelwa kuya ekuhlaziyweni okuningiliziwe kwezakhi zofuzo—ukuqinisekisa ukungenelela ngesikhathi esifanele kanye nokunciphisa ukusabalala kwamagciwane amelana namagciwane.
Ukulwa ne-AMR nge-Precision Diagnostics
Kwa-Macro & Micro-Test, sinikeza amakhithi okuxilonga asezingeni eliphezulu anika amandla abahlinzeki bezempilo ngokuqonda okusheshayo nokuthembekile, okuvumela ukulungiswa kokwelashwa okufika ngesikhathi kanye nokulawulwa kokutheleleka okuphumelelayo.
Njengoba kugcizelelwe ngesikhathi se-World Awareness AMR Week, ukukhetha kwethu namuhla kuzonquma ikhono lethu lokuvikela izizukulwane zamanje nezesikhathi esizayo engcupheni yokumelana namagciwane.
Joyina impi yokulwa nokumelana namagciwane—konke ukuphila okusindisiwe kubalulekile.
For more information, please contact: marketing@mmtest.com
Isikhathi sokuthunyelwe: Novemba-19-2025