Ukumelana ne-Antimicrobial Resistant (AMR) sekungenye yezinsongo ezinkulu kakhulu zezempilo yomphakathi kuleli khulu leminyaka, okubangela ngokuqondile ukufa kwabantu abangaphezu kwezigidi ezingu-1.27 unyaka ngamunye futhi kube nomthelela ezingozini ezengeziwe ezicishe zibe yizigidi ezi-5—le nkinga yezempilo ephuthumayo emhlabeni wonke idinga isinyathelo sethu esisheshayo.
Kuleli sonto Lomhlaba Lokuqwashisa Nge-AMR (November 18-24), abaholi bezempilo emhlabeni wonke bayahlangana obizweni lwabo:"Yenza Manje: Vikela Imanje Sethu, Uvikele Ikusasa Lethu."Le timu igcizelela ukuphuthuma ekubhekaneni ne-AMR, edinga imizamo ehlelekile kuyo yonke imikhakha yezempilo yabantu, yezilwane, kanye neyemvelo.
Usongo lwe-AMR lweqa imingcele kazwelonke nezizinda zokunakekelwa kwezempilo. Ngokocwaningo lwakamuva lwe-Lancet, ngaphandle kokungenelela okuphumelelayo ngokumelene ne-AMR,inani lokufa kwabantu emhlabeni wonke lingafinyelela ezigidini ezingama-39 ngo-2050, kuyilapho izindleko zonyaka zokwelapha izifo ezingazweli emishanguzweni kulindeleke ukuthi zikhuphuke zisuka ezigidini eziyizinkulungwane ezingu-66 zamaRandi$159 billion.
Inkinga ye-AMR: Iqiniso Elinzima Ngemva Kwezinombolo
Ukumelana ne-Antimicrobial (AMR) kwenzeka lapho amagciwane—amagciwane, amagciwane, izimuncagazi, nesikhunta—singasaphenduli emithini evamile elwa namagciwane. Le nkinga yezempilo yomhlaba wonke isifinyelele izinga elishaqisayo:
-Njalo ngemizuzu emi-5, umuntu ongu-1 ubulawa isifo esimelana nama-antibiotic
-Ngo2050, i-AMR inganciphisa i-GDP yomhlaba wonke ngo-3.8%
-Amazwe angama-96%.(ingqikithi eyi-186) ibambe iqhaza ocwaningweni lokulandela umkhondo lwe-AMR lwango-2024, okubonisa ukuqashelwa okusabalele kwalolu songo.
-Ezindlini zabagula kakhulu kwezinye izifunda,ngaphezu kwe-50% ye-bacterial isolateskhombisa ukumelana okungenani nemithi elwa namagciwane eyodwa
Indlela Ama-antibiotics Ahluleka ngayo: Izindlela Zokuzivikela Zezinambuzane Ezincane
Ama-antibiotic asebenza ngokukhomba izinqubo ezibalulekile zebhaktheriya:
-I-Cell Wall Synthesis: Ama-penicillin aphazamisa izindonga zamangqamuzana amagciwane, abangele ukugqashuka kwamagciwane nokufa
-Ukukhiqizwa KwamaprotheniI-Tetracyclines nama-macrolides avimba ama-ribosomes amagciwane, amise ukwakheka kwamaprotheni
-I-DNA/RNA Replication: I-Fluoroquinolones ivimbela ama-enzyme adingekayo ekuphindaphindeni kwe-DNA yebhaktheriya
-Ubuqotho BeMembrane Yeseli: Ama-Polymyxins alimaza ulwelwesi lwamangqamuzana amagciwane, okuholela ekufeni kwamangqamuzana
-Izindlela ze-Metabolic: I-sulfonamides ivimba izinqubo ezibalulekile zebhaktheriya njenge-folic acid synthesis
Kodwa-ke, ngokukhethwa kwemvelo nokuguqulwa kwezakhi zofuzo, amagciwane akha izindlela eziningi zokumelana nama-antibiotics, okuhlanganisa ukukhiqiza ama-enzyme angasebenzi, ukuguqula okuhlosiwe kwezidakamizwa, ukunciphisa ukuqoqwa kwezidakamizwa, nokwenza ama-biofilms.
I-Carbapenemase: "Isikhali Esikhulu" ku-AMR Crisis
Phakathi kwezindlela ezihlukahlukene zokumelana, ukukhiqizwa kwei-carbapenemasiphathelene ikakhulukazi. Lawa ma-enzyme e-hydrolyze ama-antibiotic e-carbapenem-ngokuvamile abhekwa njengezidakamizwa "zomugqa wokugcina". I-Carbapenemase isebenza "njengezikhali ezinhle kakhulu" zebhaktheriya, idiliza ama-antibiotics ngaphambi kokuba ingene kumaseli ebhaktheriya. Amagciwane aphethe la ma-enzyme—njengaKlebsiella inyumoniyafuthiI-Acinetobacter baumannii—ingaphila futhi ande ngisho nalapho echayeke kumithi elwa namagciwane enamandla kakhulu.
Okushaqisayo nakakhulu, izakhi zofuzo ezifaka ikhodi ye-carbapenemase zitholakala kuzakhi zofuzo ezihambayo ezingadlulisa phakathi kwezinhlobo ezahlukene zamagciwane,ukusheshisa ukusabalala komhlaba wonke kwamagciwane amelana nezidakamizwa.
Ukuxilongas: Umugqa Wokuqala Wokuvikela Ekulawuleni kwe-AMR
Ukuxilongwa okunembile, okusheshayo kubalulekile ekulweni ne-AMR. Ukuhlonza amabhaktheriya amelana ngesikhathi kunga:
- Qondisa ukwelashwa okunembayo, ugweme ukusetshenziswa kwama-antibiotic okungasebenzi
-Sebenzisa izinyathelo zokulawula ukutheleleka ukuvimbela ukudluliswa kwamagciwane amelana
-Qapha izitayela zokumelana nokwazisa izinqumo zezempilo zomphakathi
Izisombululo Zethu: Amathuluzi Athuthukile E-Precision AMR Combat
Ukuze kubhekwane nenselelo ekhulayo ye-AMR, i-Macro & Micro-Test ithuthukise amakhithi amathathu okuthola i-carbapenemase amasha ahlangabezana nezidingo ezahlukene zomtholampilo, ukusiza abahlinzeki bezempilo ukuthi babone ngokushesha futhi ngokunembile amagciwane amelana ukuze kuqinisekiswe ukungenelela okufika ngesikhathi kanye nemiphumela ethuthukisiwe yesiguli.
1. Ikhithi Yokuthola I-Carbapenemase (Igolide Le-Colloidal)
Isebenzisa ubuchwepheshe begolide be-colloidal ukuthola ngokushesha, okuthembekile kwe-carbapenemase. Ifanele izibhedlela, imitholampilo, ngisho nokusetshenziswa kwasekhaya, okwenza inqubo yokuxilonga ibe lula ngokunemba okuphezulu.
Izinzuzo ezibalulekile:
-Ukutholwa Okuphelele: Ngesikhathi esifanayo ikhomba izakhi zofuzo ezinhlanu zokumelana—i-NDM, i-KPC, i-OXA-48, i-IMP, ne-VIM
-Imiphumela Esheshayo: Inikeza imiphumela ngaphakathiImizuzu engu-15, ngokushesha okukhulu kunezindlela zendabuko (izinsuku ezingu-1-2)
-Easy Operation: Azikho izinto ezisetshenziswayo eziyinkimbinkimbi noma ukuqeqeshwa okukhethekile okudingekayo, ezifanele izilungiselelo ezihlukahlukene
-Ukunemba Okuphezulu: 95% ukuzwela okungenazo izinto ezingamanga ezivela kubhaktheriya evamile njenge-Klebsiella pneumoniae noma i-Pseudomonas aeruginosa
2. I-Carbapenem Resistance Gene Detection Kit (Fluorescence PCR)
Idizayinelwe ukuhlaziywa kofuzo okujulile kokumelana ne-carbapenem. Ilungele ukubhekwa okuphelele kumalabhorethri omtholampilo, ihlinzeka ngokutholakala okunembile kwezakhi zofuzo eziningi zokumelana ne-carbapenem.
Izinzuzo ezibalulekile:
-Ukusampula Okuguquguqukayo: Ukutholwa okuqondile okuvelaamakoloni ahlanzekile, isikhwehlela, noma ama-rectal swabs-akukho isikookudingekayo
-Ukwehliswa Kwezindleko: Ithola izakhi zofuzo eziyisihluthulelo eziyisithupha (NDM, KPC, OXA-48, OXA-23) IMP, kanye ne-VIM ekuhlolweni okukodwa, kuqedwe ukuhlolwa okungafuneki
-Ukuzwela Okuphezulu kanye Nokucaciswa: Umkhawulo wokutholwa uphansi njengo-1000 CFU/mL, akukho ukuphinda kusebenze nezinye izinhlobo zofuzo zokumelana njenge-CTX, i-mecA, i-SME, i-SHV, ne-TEM
-Ukuhambisana Okubanzi: IyahambisanaIsampula-kuya-ImpenduloI-AIO 800 i-POCT yamangqamuzana ezenzakalelayo ngokugcwele namathuluzi e-PCR ajwayelekile
3. I-Klebsiella pneumoniae, i-Acinetobacter baumannii, i-Pseudomonas aeruginosa kanye ne-Resistance Genes Multiplex Detection Kit (i-Fluorescence PCR)
Le khithi ihlanganisa ukuhlonza amagciwane kanye nezindlela zokumelana ezihambisanayo zibe inqubo eyodwa ehlelekile yokuxilongwa okuphumelelayo.
Izinzuzo ezibalulekile:
-Ukutholwa Okuphelele: Ikhomba kanyekanyeamagciwane amathathu abalulekile ebhaktheriya—I-Klebsiella pneumoniae, i-Acinetobacter baumannii, ne-Pseudomonas aeruginosa—futhi ithola izakhi zofuzo ezine ezibalulekile ze-carbapenemase (KPC, NDM, OXA48, ne-IMP) ekuhlolweni okukodwa
-Ukuzwela Okuphezulu: Iyakwazi ukubona i-DNA yebhaktheriya ekugxilweni okuphansi njenge-1000 CFU/mL
-Isekela Isinqumo Somtholampilo: Isiza ukukhethwa kwemithi elwa namagciwane esebenzayo ngokuhlonzwa kusenesikhathi kwezinhlobo ezingazweli
-Ukuhambisana Okubanzi: IyahambisanaIsampula-kuya-ImpenduloI-AIO 800 i-POCT yamangqamuzana ezenzakalelayo ngokugcwele namathuluzi e-PCR ajwayelekile
Lawa makhithi okuhlonza ahlinzeka ochwepheshe bezempilo ngamathuluzi okubhekana ne-AMR kumazinga ahlukene—kusukela ekuhlolweni okusheshayo kokunakekelwa kuya ekuhlaziyweni kofuzo okunemininingwane—ukuqinisekisa ukungenelela okufika ngesikhathi kanye nokunciphisa ukusabalala kwamagciwane amelana.
Ukulwa ne-AMR nge-Precision Diagnostics
Ku-Macro & Micro-Test, sihlinzeka ngezinsiza zokuxilonga ezisezingeni eliphezulu ezinikeza abahlinzeki bezempilo amandla ngemininingwane esheshayo, enokwethenjelwa, evumela ukulungiswa kokwelashwa okufika ngesikhathi kanye nokulawula ukutheleleka ngempumelelo.
Njengoba kugcizelelwe phakathi Neviki Lokuqwashisa Nge-AMR Lomhlaba, ukukhetha kwethu namuhla kuzonquma amandla ethu okuvikela izizukulwane zamanje nezesikhathi esizayo ekusongelweni kokumelana nama-antimicrobial.
Joyina impi yokulwa nokulwa namagciwane—zonke izinto ezisindisiwe zokuphila.
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Isikhathi sokuthumela: Nov-19-2025