Ukuguqulwa kwe-C. diff Ukutholwa: Ukufeza Ukuxilongwa Kwama-Molecular Okuzenzakalelayo Ngokugcwele, Okwenziwa Isibonelo Sokuphendula

Yini ebangela ukutheleleka kwe-C. Diff?

1. Ukutheleleka kwe-Diff kubangelwa igciwane elaziwa ngokuthi i-Clostridioides difficile (C. difficile), elivame ukuhlala emathunjini ngendlela engenangozi. Kodwa-ke, lapho ibhalansi yamagciwane emathunjini iphazamiseka, kuvame ukusetshenziswa ama-antibiotic amaningi,C. kunzimaingakhula ngokweqile futhi ikhiqize ubuthi, okuholela ekuthelelekeni.

Leli gciwane likhona kokubili ezinhlotsheni ze-toxigenic kanye nezinga-toxigenic, kodwa izinhlobo ze-toxigenic kuphela (ubuthi A no-B) ezibangela izifo. Zibangela ukuvuvukala ngokuphazamisa amangqamuzana e-epithelial emathunjini. I-Toxin A ngokuyinhloko iyi-enterotoxin elimaza ulwelwesi lwamathumbu, yandise ukungena kwamanzi, futhi idonse amangqamuzana omzimba akhipha ama-cytokine avuvukalayo. I-Toxin B, i-cytotoxin enamandla kakhulu, ihlasela i-actin cytoskeleton yamangqamuzana, okuholela ekujikelezeni kwamangqamuzana, ekuqhekekeni, futhi ekugcineni ekufeni kwamangqamuzana. Ndawonye, ​​lobu buthi bubangela ukulimala kwezicubu kanye nokusabela okuqinile kwamasosha omzimba, okubonakala njenge-colitis, isifo sohudo, futhi ezimweni ezimbi kakhulu, i-pseudomembranous colitis—ukuvuvukala okukhulu kwekholoni.

I-C. Diff isakazeka kanjani?

1. Ukwanda kwanda kalula. Kutholakala ezibhedlela, kuvame ukutholakala ezindaweni zokunakekelwa kwempilo, ezandleni zabasebenzi basesibhedlela, phansi nasezinsikeni zesibhedlela, kuma-thermometer kagesi, nakwezinye izinto zokwelapha…

Izici Zengozi Zokutheleleka Kwe-C. Diff

• Ukulaliswa esibhedlela isikhathi eside;
• Ukwelashwa ngama-antimicrobial;
• Ama-ejenti e-Chemotherapy;
• Ukuhlinzwa kwakamuva (imikhono yesisu,ukudlula kwesisu, ukuhlinzwa kwamathumbu amakhulu);
• Ukudla okunempilo kwamathumbu;
• Ukutheleleka kwe-C. diff kwangaphambilini;

Izimpawu zokutheleleka kwe-C. Diff

Ukutheleleka kwe-C. diff kungaba yinto engakhululeki kakhulu. Iningi labantu liba nesifo sohudo esiqhubekayo kanye nokungakhululeki esiswini. Izimpawu ezivame kakhulu yilezi:uhudo, ubuhlungu besisu, isicanucanu, ukulahlekelwa yisifiso sokudla, umkhuhlane.

Njengoba ukutheleleka kwe-C. diff kuba kubi kakhulu, kuzoba nokuthuthukiswa kohlobo oluyinkimbinkimbi kakhulu lwe-C. diff olwaziwa ngokuthii-colitis, i-pseudomembrane enteritis kanye nokufa.

Ukuxilongwa Kokutheleleka Kwe-C. Diff

Isiko Lamagciwane: Kuyazwela kodwakuthatha isikhathi (izinsuku ezingu-2-5), ayikwazi ukuhlukanisaizinhlobo ze-toxigen kanye nezinga-toxigen;

Isiko Lobuthi:ikhomba izinhlobo ezinobuthi ezibangela izifo kodwa ezithatha isikhathi (izinsuku ezingu-3-5) futhi ezingazweli kakhulu;

Ukutholwa kwe-GDH:iyashesha (amahora angu-1-2) futhi iyabiza, ibucayi kakhulu kodwa ayikwazi ukuhlukanisa izinhlobo ze-toxigen kanye nezinga-toxigen;

Ukuhlolwa Kokungathathi hlangothi Kwe-Cell Cytotoxicity (CCNA):ithola ubuthi A no-B ngokuzwela okuphezulu kodwa ithatha isikhathi (izinsuku ezi-2-3), futhi idinga izikhungo ezikhethekile nabasebenzi abaqeqeshiwe;

I-Toxin A/B ELISA: Ukuhlolwa okulula nokusheshayo (amahora angu-1-2) okunokuzwela okuphansi kanye nokungalungi okuvamile;

Ukuhlolwa Kokukhulisa I-Nucleic Acid (ama-NAAT): Iyashesha (1-3hr) futhi ibucayi kakhulu futhi iqondile, ithola izakhi zofuzo ezibangela ukukhiqizwa kobuthi;

Ngaphezu kwalokho, ukuhlolwa kwezithombe ukuhlola amathumbu, njengokuthiUkuskena kwe-CTfuthiAma-X-ray, ingasetshenziswa futhi ukusiza ekuxilongweni kwe-C. diff kanye nezinkinga ze-C. diff, njenge-colitis.

Ukwelashwa kokutheleleka kwe-C. Diff

Kunezindlela eziningi zokwelapha ezitholakalayo zokutheleleka kwe-C. diff. Nazi izindlela ezingcono kakhulu:

• Ama-antibiotic asetshenziswa ngomlomo njenge-vancomycin, i-metronidazole noma i-fidaxomicin avame ukusetshenziswa njengoba umuthi ungadlula ohlelweni lokugaya ukudla futhi ufinyelele emathunjini lapho kuhlala khona amabhaktheriya e-C. diff.
• I-metronidazole efakwa emthanjeni ingasetshenziswa ekwelapheni uma ukutheleleka kwe-C. diff kukubi kakhulu.
• Ukufakelwa kwe-fecal microbiota kubonise ukusebenza kahle ekwelapheni ukutheleleka okuvamile kwe-C. diff kanye nokutheleleka okukhulu kwe-C. diff okungaphenduli kuma-antibiotic.
• Ukuhlinzwa kungadingeka ezimweni ezinzima.

U-d osungula izinto ezintshaisisombululo sokuxilonga esivela ku-MMT

Ukuphendula isidingo sokuthola ngokushesha nangokunembile i-C. difficile, sethula i-Nucleic Acid Detection Kit yethu entsha ye-Clostridium difficile toxin A/B gene, sinike amandla ochwepheshe bezempilo ukuthi benze ukuxilongwa kusenesikhathi nangokunembile kanye nokusekela ukulwa nokutheleleka okutholakale esibhedlela.

• Ukuzwela Okuphezulu: Ithola inani eliphansi njenge200 CFU/mL,;
• Ukuqondisa Okunembile: Ikhomba ngokunembile C. kunzimai-toxin A/B gene, ukunciphisa imiphumela engamanga;
• Ukutholwa Kwe-Pathogen Okuqondile: Isebenzisa ukuhlolwa kwe-nucleic acid ukuhlonza ngqo izakhi zofuzo zobuthi, isungula indinganiso yegolide yokuxilonga.
• Ihambisana ngokugcwele neamathuluzi e-PCR ajwayelekile abhekana nama-lab amaningi;

Isixazululo Sesampula-Ukuphendula sivuliweUkuhlolwa Okukhulu Nokuncane'sI-AIO800Ilebhu ye-PCR yeselula

Ukuzenzakalela Kwesampula-Ukuze-Impendulo – Layisha amashubhu esampula okuqala (1.5–12 mL) ngqo, kususa ukuphayipha ngesandla. Ukukhipha, ukukhulisa, kanye nokutholwa kwenziwa ngokuzenzakalela ngokuphelele, kunciphisa isikhathi sokusebenza kanye namaphutha omuntu.

• Ukuvikelwa Kokungcola Kwezingqimba Eziyi-11 – Ukugeleza komoya okuqondiswayo, ukucindezela okungekuhle, ukuhlunga kwe-HEPA, ukuhlanza i-UV, ukusabela okuvaliwe, kanye nezinye izindlela zokuphepha ezihlanganisiwe kuvikela abasebenzi futhi kuqinisekisa imiphumela ethembekile ngesikhathi sokuhlolwa kokuphuma okuphezulu.

Ukuze uthole imininingwane eyengeziwe:

Xhumana nathi ukuze ufunde kabanzi:marketing@mmtest.com;