Ukwelashwa Okunembile Kokuvula kwe-NSCLC ngokuhlolwa Kokuguquka Kwe-EGFR Okuthuthukisiwe

Umdlavuza wamaphaphu usalokhu uyinselele yezempilo emhlabeni wonke, ubekwa njengomdlavuza wesibili ovame ukutholakala. Ngo-2020 kuphela, kwakunamacala amasha angaphezu kwezigidi ezingu-2.2 emhlabeni jikelele. Umdlavuza wamaphaphu ongewona amaseli amancane (i-NSCLC) umele ngaphezu kwama-80% azo zonke izifo zomdlavuza wamaphaphu, okugqamisa isidingo esiphuthumayo samasu okwelapha aqondiwe futhi asebenzayo.

Ukuguqulwa kwe-EGFR kuvele njengesisekelo ekwelashweni kwe-NSCLC komuntu siqu. Ama-EGFR tyrosine kinase inhibitors (TKIs) anikeza indlela entsha ngokuvimbela izimpawu ezibangela umdlavuza, ukuvimbela ukukhula kwesimila, kanye nokukhuthaza ukufa kwamangqamuzana omdlavuza—konke lokhu kuqhubeka kunciphisa umonakalo kumaseli anempilo.

Iziqondiso zemitholampilo ezihamba phambili, okuhlanganisa ne-NCCN, manje seziyalela ukuhlolwa kokuguquka kwe-EGFR ngaphambi kokuqala ukwelashwa kwe-TKI, ukuqinisekisa ukuthi iziguli ezifanele zithola imithi efanele kusukela ekuqaleni.

Ukuguqulwa kwe-EGFR kuvele njengesisekelo ekwelashweni kwe-NSCLC komuntu siqu. Ama-EGFR tyrosine kinase inhibitors (TKIs) anikeza indlela entsha ngokuvimbela izimpawu ezibangela umdlavuza, ukuvimbela ukukhula kwesimila, kanye nokukhuthaza ukufa kwamangqamuzana omdlavuza—konke lokhu kuqhubeka kunciphisa umonakalo kumaseli anempilo.

Iziqondiso zemitholampilo ezihamba phambili, okuhlanganisa ne-NCCN, manje seziyalela ukuhlolwa kokuguquka kwe-EGFR ngaphambi kokuqala ukwelashwa kwe-TKI, ukuqinisekisa ukuthi iziguli ezifanele zithola imithi efanele kusukela ekuqaleni.

Kwethulwa i-Human EGFR Gene 29 Mutations Detection Kit (i-Fluorescence PCR)
Ukutholwa Okunembile Kwezinqumo Zokwelapha Eziqinisekile

Ikhithi yokuthola i-EGFR ye-Macro & Micro-Test ivumela ukuhlonza okusheshayo nokunembile kwezinguquko ezingu-29 ezibalulekile kuwo wonke ama-exons 18-21 kokubili kuma-biopsies ezicubu kanye noketshezi— okunikeza odokotela amandla okwenza ukwelashwa ngendlela efanele.

Kungani UkhethaUkuhlolwa Okukhulu Nokuncane'sIkhithi Yokuhlola ye-EGFR?

Le khithi ithola izinguquko zezakhi zofuzo ze-EGFR ezingu-29 ezivamile kuma-exons 18-21 avela kumasampula ezicubu noma egazi eziguli ze-NSCLC, ihlanganisa ukuzwela kwemithi kanye nezindawo zokumelana nokusetshenziswa kwayo ukuze iqondise ukusetshenziswa kwemithi eqondiwe njenge-gefitinib kanye ne-osimertinib.

1. 1. Ubuchwepheshe be-ARMS obuthuthukisiwe: I-ARMS ethuthukisiwe ene-enhancer enelungelo lobunikazi ukuze icaciseke kakhulu;
2. 2. Ukucebisa nge-Enzymatic: Kunciphisa isizinda sohlobo lwasendle ngokugaya nge-enzymatic, kuthuthukise ukunemba kokutholwa futhi kunciphise ukwanda okungaqondile ngenxa yesizinda esiphezulu se-genomic;
3. 3. Ukuvinjelwa Kwezinga Lokushisa: Kwengeza izigaba ezithile zokushisa enqubweni ye-PCR, kunciphisa ukungalingani kanye nokwandisa ukunemba kokutholwa;
4. 4. Ukuzwela Okuphezulu: Ithola izinguquko eziphansi njengezinguquko ezingu-1%;
5. 5. Ukunemba Okukhulu: Ukulawula kwangaphakathi kanye ne-enzyme ye-UNG ukunciphisa imiphumela engamanga;
6. 6. Ukusebenza kahle: Imiphumela eqondile ingakapheli imizuzu eyi-120
7. 7. Ukusekelwa Kwesampula Ekabili - Kwenzelwe kokubili amasampula ezicubu kanye negazi, okunikeza ukuguquguquka ekusebenzeni kwezokwelapha
8. 8. Ukuhambisana okubanzi: Kuhambisana kakhulu nezinsimbi ze-PCR ezivamile emakethe;
9. 9. Impilo yeshelufu: izinyanga eziyi-12.

Ukwelapha Okuqondisiwe Ngokuzethemba
Le khithi isiza ukukhulisa imiphumela yezokwelapha futhi ihlale iphambili kunokumelana nokuzwela okubucayi kanye nokuguqulwa kokumelana.

Nweba iphothifoliyo yakho ye-Precision Oncology
Hlola uhla lwethu oluphelele lwezixazululo zokuthola ukuguquka kwezakhi zofuzo ze-KRAS, BRAF, ROS1, ALK, BCR-ABL, TEL-AML1, nokuningi—konke kuklanyelwe ukusekela ukunakekelwa okuphelele okuqhutshwa yi-biomarker.

Funda kabanzi:https://www.mmtest.com/oncology/

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