Vula Ukwelashwa Okunembayo kwe-NSCLC Ngokuhlolwa Okuthuthukisiwe Kokuguqulwa Kwe-EGFR

Umdlavuza wamaphaphu useyinselelo yezempilo yomhlaba wonke, ubalwa njengomdlavuza wesibili otholakala kakhulu. Ngo-2020 kuphela, kube namacala amasha angaphezu kwezigidi ezi-2.2 emhlabeni jikelele. Umdlavuza wamaphaphu ongewona omncane (i-NSCLC) umele ngaphezu kwama-80% azo zonke izifo zokuxilonga umdlavuza wamaphaphu, okugqamisa isidingo esiphuthumayo samasu okwelapha ahlosiwe futhi asebenzayo.

Ukuguqulwa kwe-EGFR kuye kwavela njengesisekelo sokwelashwa komuntu siqu kwe-NSCLC. I-EGFR tyrosine kinase inhibitors (TKIs) inikezela ngendlela yokuguqula ngokuvimbela amasiginali okushayela umdlavuza, ivimbele ukukhula kwesimila, futhi ikhuthaze ukufa kwamangqamuzana omdlavuza-konke kuyilapho kunciphisa umonakalo kumaseli anempilo.

Imihlahlandlela ehamba phambili yomtholampilo, kuhlanganise ne-NCCN, manje igunyaza ukuhlolwa kokuguqulwa kwe-EGFR ngaphambi kokuqala ukwelashwa kwe-TKI, iqinisekisa ukuthi iziguli ezifanele zithola imithi efanele kusukela ekuqaleni.

Ukuguqulwa kwe-EGFR kuye kwavela njengesisekelo sokwelashwa komuntu siqu kwe-NSCLC. I-EGFR tyrosine kinase inhibitors (TKIs) inikezela ngendlela yokuguqula ngokuvimbela amasiginali okushayela umdlavuza, ivimbele ukukhula kwesimila, futhi ikhuthaze ukufa kwamangqamuzana omdlavuza-konke kuyilapho kunciphisa umonakalo kumaseli anempilo.

Imihlahlandlela ehamba phambili yomtholampilo, kuhlanganise ne-NCCN, manje igunyaza ukuhlolwa kokuguqulwa kwe-EGFR ngaphambi kokuqala ukwelashwa kwe-TKI, iqinisekisa ukuthi iziguli ezifanele zithola imithi efanele kusukela ekuqaleni.

Sethula i-Human EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR)
Ukutholwa Okunembayo Kwezinqumo Zokwelashwa Ngokuqiniseka

Ikhithi yokuhlonza ye-EGFR ye-Macro & Micro-Test inika amandla ukuhlonzwa okusheshayo nokunembile kwezinguquko ezibalulekile ezingu-29 kuwo wonke ama-exons 18–21 kuzo zombili izicubu nama-biopsy oketshezi— kunikeza odokotela amandla ukuze bahlanganise ukwelashwa ngokuzethemba.

Kungani KhethaI-Macro & Micro-Test'sIkhithi yokuhlola ye-EGFR?

Ikhithi ithola ukuguqulwa kofuzo okujwayelekile okungu-29 kwe-EGFR kuma-exons 18-21 kusuka kuzicubu noma amasampula egazi eziguli ze-NSCLC, okumboza ukuzwela kwezidakamizwa nezindawo zokumelana nokuqondisa ukusetshenziswa kwezidakamizwa ezihlosiwe njenge-gefitinib ne-osimertinib.

1. 1.Ubuchwepheshe be-ARMS obuthuthukisiwe: I-ARMS ethuthukisiwe enesithuthukisi esinelungelo lobunikazi ukuze kube nokucaciswa okuphezulu;
2. 2.I-Enzymatic Enrichment: Yehlisa ingemuva lohlobo lwasendle ngokugayeka kwe-enzymatic, ithuthukise ukunemba kokutholwa kanye nokunciphisa ukukhulisa okungaqondile ngenxa yesizinda se-genomic ephezulu;
3. I-3.Ukuvimbela Ukushisa: Yengeza izigaba ezithile zokushisa kwinqubo ye-PCR, ukunciphisa ukungafani nokwandisa ukunemba kokutholwa;
4. 4.Ukuzwela Okuphezulu: Ithola ukuguqulwa kwezakhi zofuzo okuphansi njengokungu-1%;
5. 5.Ukunemba Okukhulu: Ukulawula kwangaphakathi kanye ne-UNG enzyme yokunciphisa imiphumela engamanga;
6. I-6.Ukusebenza kahle: Imiphumela yezinhloso ngaphakathi kwe-120 min
7. 7.Ukusekelwa Kwesampula Okubili - Kwenzelwe kokubili amasampula ezicubu negazi, okuhlinzeka ngokuguquguquka ekusebenzeni komtholampilo
8. 8.Ukuhambisana okubanzi: Ihambisana kakhulu namathuluzi e-PCR ajwayelekile emakethe;
9. 9.Impilo yeshelufu: izinyanga eziyi-12.

I-Guide Therapy ngokuzethemba
Ikhithi isiza ukukhulisa imiphumela yomtholampilo futhi uhlale ngaphambi kokumelana nokuzwela okubucayi kanye nokuguqulwa kokumelana.

Nweba Iphothifoliyo Yakho Ye-Precision Oncology
Hlola uhla lwethu olugcwele lwezixazululo zokuthola ukuguqulwa kwe-KRAS, BRAF, ROS1, ALK, BCR-ABL, TEL-AML1, nokuningi—konke okuklanyelwe ukusekela ukunakekelwa okuphelele okuqhutshwa yi-biomarker.

Funda kabanzi:https://www.mmtest.com/oncology/

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