Yini i-denguimfivakanye ne-DENVvirus?
I-Dengue fever ibangelwa igciwane lodenga (DENV), elidluliselwa ikakhulukazi kubantu ngokulunywa omiyane besifazane abanaleli gciwane, ikakhulukazi i-Aedes aegypti ne-Aedes albopictus.
Kunezinhlobo ezine ezihlukene ze-serotypes zegciwane (i-DENV-1, i-DENV-2, i-DENV-3, ne-DENV-4). Ukutheleleka nge-serotype eyodwa kunikeza ukuvikeleka kwempilo yonke kuleyo serotype kodwa hhayi kwabanye.
Udenga lusakazwa kakhulu ngokulunywa omiyane. Izici ezibalulekile zokudluliswa kwayo zifaka:
I-Vector:II-Aedes yaseGibhitheomiyane bayachuma ezindaweni zasemadolobheni futhi bazalela emanzini amile.Aedes albopictuslingadlulisela igciwane kodwa alivamile kangako.
Ukudluliswa Komuntu Kusuka Emiyani:Lapho umiyane uluma umuntu onaleli gciwane, leli gciwane lingena kumiyane futhi lingadluliselwa komunye umuntu ngemva kwesikhathi sokufukamela esiyizinsuku ezingaba ngu-8-12.
Kungani sinomkhuhlane wodenga ngisho nasemazweni angewona ashisayo?
Ukushintsha Kwesimo Sezulu: Amazinga okushisa akhuphukayo emhlabeni wonke andisa indawo yokuhlalaOmiyane be-Aedes,ama-vector ayinhloko odenga.
Ukuhamba Nohwebo Kwembulunga yonke: Ukwenyuka kokuhamba nokuhweba kwamanye amazwe kungaholela ekwethulweni komiyane abathwala udenga noma abantu abanaleli gciwane ezindaweni ezingezona ezishisayo.
Ukufudukela emadolobheni: Ukuthuthela emadolobheni ngokushesha ngaphandle kokuphathwa kwamanzi okwanele, okudala izindawo zokuzalela komiyane.
Ukuzijwayeza Umiyane: Omiyane be-Aedes, ikakhulukaziI-Aedes yaseGibhithefuthiI-Aedesi-albopictus, zijwayelana nezimo zezulu ezipholile zezindawo ezinjengezingxenye zaseYurophu naseNyakatho Melika.
Lezi zici zifaka isandla ngokuhlanganyela ekukhuleni kodenga ezindaweni ezingezona ezishisayo.
Indlela yokuxilonga nokwelapha i-dengue fever?
Ukuxilongwa kodenga kungase kube nzima ngenxa yezimpawu zayo ezingaqondile, ezingalingisa ezinye izifo ezibangelwa amagciwane.
Izimpawu:Izimpawu zokuqala zivame ukuvela ezinsukwini ezi-4-10 ngemuva kokutheleleka okubandakanya ukushisa okuphezulu, ikhanda elibuhlungu, ubuhlungu be-retro-orbital, ubuhlungu bamalunga nemisipha, ukuqubuka, nokopha okuncane. Ezimweni ezimbi kakhulu, udenga lungadlulela kumkhuhlane wodenga (DHF) noma i-dengue shock syndrome (DSS), okungase kusongela ukuphila. Ukutholwa kusenesikhathi kusiza ekulawuleni izimpawu ngaphambi kokuba zibe zimbi kakhulu.
Ukutholwamethods fordengu:
SUkuhlolwa kwe-erology:Thola amasosha omzimba (IgM ne-IgG) ngokumelene ne-DENV, nge-IgM ekhombisa ukutheleleka kwakamuva kanye ne-IgG ephakamisa ukuchayeka okwedlule. Lezi zivivinyo zivame ukusetshenziswa kuimitholampilofuthiama-laboratories aphakathi nendawoukuqinisekisa ukutheleleka kwamanje noma kwangaphambilini ngesikhathi sokululama noma kubantu abangenazimpawu zesifo abanomlando wokuchayeka.
Ukuhlolwa kwe-NS1 Antigen:Thola iphrotheni engeyona yesakhiwo 1 (NS1) phakathi nesigaba sokuqala sokutheleleka, esebenza njengethuluzi lokuxilonga kusenesikhathi, elilungele ukutholwa ngokushesha phakathi kwezinsuku zokuqala ezi-1-5 zokubonakala kwezimpawu. Lezi zivivinyo zivame ukwenziwa kuizilungiselelo zendawo yokunakekelanjengeimitholampilo, izibhedlela, futhiiminyango yezimo eziphuthumayoukuze kuthathwe izinqumo ngokushesha kanye nokuqaliswa kokwelashwa.
Ukuhlolwa kwe-NS1 + IgG/IgM:Thola kokubili izifo ezikhona nezidlule ngokuhlola amaprotheni egciwane kanye namasosha omzimba egazini, okuwenza abe usizo ekuhlukaniseni phakathi kwezifo zakamuva kanye nokuchayeka okwedlule, noma ukuhlonza izifo zesibili. Lezi zivame ukusetshenziswa kuizibhedlela, imitholampilo, futhiama-laboratories aphakathi nendawoukuze kuhlolwe ukuxilonga okuphelele.
Ukuhlolwa kwamangqamuzana:Thola i-RNA yegciwane egazini, ephumelela kakhulu phakathi nesonto lokuqala lokugula, futhi isetshenziswe ekuqaleni kokutheleleka ukuze kuqinisekiswe okunembile, ikakhulukazi ezimweni ezibucayi. Lezi zivivinyo zenziwa ngokuyinhloko kuama-laboratories aphakathi nendawongamakhono okuxilonga amangqamuzana ngenxa yesidingo semishini ekhethekile.
Ukulandelanisa:Ihlonza izakhi zofuzo ze-DENV ukuze kufundwe izici zayo, ukuhlukahluka, kanye nokuziphendukela kwemvelo, okubalulekile ocwaningweni lwe-epidemiological, uphenyo lokuqubuka, kanye nokulandelela ukuguqulwa kwegciwane kanye namaphethini okudlulisela. Lokhu kuhlolwa kwenziwa kuamalabhorethri ocwaningofuthiamalebhu ezempilo yomphakathi akhethekileukuhlaziya okujulile kwe-genomic kanye nezinjongo zokugada.
Njengamanje, akukho ukwelashwa okuqondile kwe-antiviral yodenga. Ukuphatha kugxile ekunakekelweni okusekelayo njengokufakwa emanzini, ukukhulula ubuhlungu nokuqapha ngokucophelela. Kufanele kuqashelwe ukuthi ukuhlonzwa kusenesikhathi kokutheleleka kodenga kungavimbela imiphumela emibi.
I-Macro & Micro-Test ihlinzeka ngezinsiza ezihlukahlukene zokuxilonga ze-RDT, i-RT-PCR kanye nokulandelana kokutholwa kodenga nokuqapha ubhubhane:
I-Dengue Virus I/II/III/IV NucleicIkhithi Yokuthola I-Acid- uketshezi / i-lyophilized;
I-Dengue NS1 Antigen, I-IgM/IgG AntibodyI-Dual Detection Kit;
HWTS-FE029-Ikhithi Yokuthola I-Dengue NS1 Antigen
Izinhlobo Zegciwane Lodenga 1/2/3/4 Ikhithi Yokucebisa I-Genome Yonke (Indlela Yokukhulisa I-Multiplex)
Iphepha elihlobene:
https://www.sciencedirect.com/science/article/abs/pii/S0168170218300091?via%3Dihub
Isikhathi sokuthumela: Oct-21-2024