I-progesterone (P)

I-progesterone iyi-progestogen ebalulekile, eyingxenye yamahomoni e-steroid, enesisindo samangqamuzana esihlobene esingu-314.5.Ikhiqizwa ikakhulukazi yi-corpus luteum ye-ovary kanye ne-placenta ngesikhathi sokukhulelwa.Kungumanduleli we-testosterone, i-estrogen ne-adrenal cortex hormone.Izinga le-progesterone elikhiqizwa phakathi nesigaba se-follicular labesilisa nabesifazane abavamile liphansi kakhulu, ngemva kokuphumela egazini, liboshelwe ikakhulukazi ku-albumin namahomoni ocansi abopha amaprotheni futhi ajikeleze emzimbeni.

Umsebenzi oyinhloko we-progesterone ukwenza isibeletho silungiselelwe ukufakwa kwamaqanda avundisiwe nokugcina ukukhulelwa.Phakathi nesigaba se-follicular somjikelezo wokuya esikhathini, izinga le-progesterone liphansi.Ngemuva kokuvuthwa, i-progesterone ekhiqizwa yi-corpus luteum ikhula ngokushesha, futhi ifinyelela ekugxilweni okuphezulu kwe-10ng/mL-20ng/mL ezinsukwini ezingu-5-7 ngemva kokuvuthwa.Uma ingakhulelwa, i-corpus luteum atrophies phakathi nezinsuku ezine zokugcina zomjikelezo wokuya esikhathini kanye nokugxila kwe-progesterone kwehla kusigaba se-follicular.Uma ikhulelwe, i-corpus luteum ayibuni futhi iyaqhubeka nokukhipha i-progesterone, igcina emazingeni alingana nesigaba se-luteal esiphakathi futhi iqhubeke kuze kube isonto lesithupha lokukhulelwa.Ngesikhathi sokukhulelwa, i-placenta kancane kancane iba umthombo oyinhloko we-progesterone, futhi ukugxila kukhuphuka kusuka ku-10ng/mL-50ng/mL ezinyangeni ezi-3 zokuqala zokukhulelwa kuya ku-50ng/mL-280ng/mL ezinyangeni ezingu-7-9.Ucwaningo lwezokwelapha luye lwabonisa ukuthi i-progesterone idlala indima ekukhuthazeni ukuphuma kweqanda nokugcina umsebenzi ojwayelekile we-corpus luteum kwabesifazane abangakhulelwe.Uma i-progesterone ekhiqizwa i-corpus luteum inganele, ingase ibonise ukuthi umsebenzi we-corpus luteum ayanele, futhi umsebenzi we-corpus luteum onganele uhlobene nokuzala nokuphuphuma kwesisu ekuqaleni.