I-Candida Albicans/Candida Tropicalis/Candida Glabrata Nucleic Acid Ihlanganisiwe

I-Candida iyisikhunta esikhulu kunazo zonke esivamile emzimbeni womuntu. Itholakala kabanzi emgudwini wokuphefumula, umgudu wokugaya ukudla, i-urogenital tract nezinye izitho ezixhumana nezwe langaphandle. Ngokuvamile, ayiyona i-pathogenic futhi ingeyamagciwane angosomathuba. Ngenxa yokusetshenziswa okubanzi kwe-immunosuppressant kanye nenani elikhulu lama-antibiotic abanzi, kanye ne-radiotherapy yesimila, i-chemotherapy, ukwelashwa okuhlaselayo, ukufakelwa kwezitho zomzimba, i-flora evamile ayilingani futhi ukutheleleka kwe-candida kwenzeka emgudwini we-genitourinary kanye nomgudu wokuphefumula. I-Candida albicans iyona evame kakhulu emtholampilo, futhi kunezinhlobo ezingaphezu kwezingu-16 ze-non-Candida albicans pathogenic bacteria, phakathi kwazo i-C. tropicalis, C. glabrata, C. parapsilosis kanye ne-C. krusei ezivame kakhulu. I-Candida albicans iyisikhunta esingosomathuba esivame ukuhlanganisa amathumbu, umgodi womlomo, isitho sangasese sowesifazane nolunye ulwelwesi lwamafinyila nesikhumba. Lapho ukumelana komzimba kuncipha noma i-microecology iphazamiseka, inganda ngamanani amakhulu futhi ibangele izifo. I-Candida tropicalis isikhunta esingosomathuba esitholakala kabanzi emvelweni nasemzimbeni womuntu. Lapho ukumelana komzimba kuncipha, i-Candida tropicalis ingabangela isikhumba, isitho sangasese sowesifazane, umgudu womchamo ngisho nezifo zesistimu.

Eminyakeni yamuva nje, phakathi kwezinhlobo ze-Candida ezihlukanisiwe neziguli ezine-candidiasis, i-Candida tropicalis ibhekwa njengeyokuqala noma yesibili engeyona i-Candida albicans (NCAC) ngezinga lokuzihlukanisa, okwenzeka ikakhulukazi ezigulini ezine-leukemia, i-immunodeficiency, i-catheterization yesikhathi eside, noma ukwelashwa ngama-antibiotic abanzi. Inani labantu abatheleleka nge-Candida tropicalis liyahluka kakhulu ngokwezindawo. Isibalo sabantu abatheleleke ngeCandida tropicalis siyahluka kakhulu ngokwezindawo. Kwamanye amazwe, ukutheleleka kwe-Candida tropicalis kudlula ngisho ne-Candida albicans. Izici ze-pathogenic zifaka i-hyphae, i-cell surface hydrophobicity, kanye nokwakheka kwe-biofilm. I-Candida glabrata iyisikhunta esivamile se-pathogenic se-vulvovaginal candidiasis (VVC). Izinga lekoloni kanye nezinga lokutheleleka kwe-Candida glabrata lihlobene neminyaka yabantu. Ikoloni kanye nokutheleleka kwe-Candida glabrata kuyivelakancane kakhulu ezinsaneni nasezinganeni, futhi izinga le-colonization kanye nezinga lokutheleleka kwe-Candida glabrata likhuphuka kakhulu ngokukhula. Ukusabalala kwe-Candida glabrata kuhlobene nezici ezifana nendawo yendawo, ubudala, inani labantu, kanye nokusetshenziswa kwe-fluconazole.