I-Clostridium Difficile Glutamate Dehydrogenase(GDH) kanye ne-Toxin A/B

I-Clostridium difficile(CD) iyisibopho se-anaerobic gram-positive bacillus, okuyisitshalo esivamile emzimbeni womuntu.Ezinye izitshalo zizovinjelwa ukuba zingaphindaphindeki ngenxa yemithi elwa namagciwane esetshenziswa ngemithamo emikhulu, futhi i-CD ikhiqiza ngobuningi emzimbeni womuntu.I-CD ihlukaniswe yaba izinhlobo ezikhiqiza ubuthi nezingakhiqizi ubuthi.Zonke izinhlobo ze-CD zikhiqiza i-glutamate dehydrogenase (GDH) lapho zizala, futhi yizinhlobo ezinobuthi kuphela ezibangela izifo.Izinhlobo ezikhiqiza ubuthi zingakhiqiza ubuthi obubili, u-A no-B. Ubuthi A yi-enterotoxin, engabangela ukuvuvukala kodonga lwamathumbu, ukungena kwamangqamuzana, ukwanda kokungena odongeni lwamathumbu, ukopha kanye ne-necrosis.I-Toxin B iyi-cytotoxin, elimaza i-cytoskeleton, ibangele i-cell pyknosis ne-necrosis, futhi ilimaza ngokuqondile amangqamuzana e-parietal amathumbu, okuholela esihudo kanye ne-pseudomembranous colitis.