I-Clostridium Difficile Glutamate Dehydrogenase (GDH) kanye ne-Toxin A/B

I-Clostridium difficile (CD) iyi-bacillus ene-gram-positive engaphoqelekile, okuyisitshalo esivamile emzimbeni womuntu. Ezinye izitshalo zizovinjelwa ekuphindaphindeni ngenxa yama-antibiotic asetshenziswa ngemithamo emikhulu, kanti i-CD izala emzimbeni womuntu ngobuningi obukhulu. I-CD ihlukaniswe ngezinhlobo ezikhiqiza ubuthi kanye nezingakhiqizi ubuthi. Zonke izinhlobo ze-CD zikhiqiza i-glutamate dehydrogenase (GDH) uma zizala, futhi izinhlobo ze-toxigenic kuphela ezibangela izifo. Izinhlobo ezikhiqiza ubuthi zingakhiqiza ubuthi obubili, u-A no-B. I-Toxin A iyi-enterotoxin, engabangela ukuvuvukala kodonga lwamathumbu, ukungena kwamaseli, ukwanda kokungena kodonga lwamathumbu, ukuphuma kwegazi kanye ne-necrosis. I-Toxin B iyi-cytotoxin, elimaza i-cytoskeleton, ibangele i-cell pyknosis kanye ne-necrosis, futhi ilimaza ngqo amaseli e-parietal amathumbu, okuholela ekuhudeni kanye ne-pseudomembranous colitis.