I-Closerpidium Efficile Glutamate dehydrogenase (GDH) neToxin A / B

I-Closerpidium Efficile (CD) iyi-bacillus ye-anaerobic gram enhle, okuyi-flora ejwayelekile emzimbeni womuntu. Amanye ama-Flora azovinjelwa ekuphindaphindweni ngenxa yemithi elwa namagciwane asetshenziswa emithanjeni emikhulu, futhi i-CD ivelela emzimbeni womuntu ngobuningi. I-CD ihlukaniswe ngezilwane ezikhiqiza ubuthi kanye ne-non-toxin. Zonke izinhlobo ze-CD zikhiqiza i-glutamate dehydrogenase (GDH) lapho zizala kabusha, futhi kuphela ama-toxigenic kuphela ama-pathogenic. Izinkomba ezikhiqiza ubuthi zingakhiqiza ubuthi obubili, u-A no-B. I-Toxin a yi-Enterotoxin, engadala ukuvuvukala kodonga lwamathumbu, ukufakwa kwamaseli, ukukhuphuka kwemvume yodonga lwamathumbu, i-hemorrhage ne-necrosis. I-Toxin B yi-Cytotoxin, elimaza i-cytoskeleton, ebangela ama-pyknosis we-cell Pyknosis kanye ne-necrosis, futhi alimaze ngokuqondile amaseli paritinal parietinal, okuholele ekuhunyushweni kwe-colitis kanye ne-pseudomembranous colitis.