Ukuguqulwa kohlobo lwe-Human Bcr-Abl Fusion
Igama lomkhiqizo
I-HWTS-GE010A-HUNTA-ABL-AbL Fusion Gene Mutual Dection Dection Kit (Fluorescence PCR)
I-HWTS-GE016A-FARLE-WREBE-ABL Fusion GcR-AbL Fusion Deetation Dection Dection Dection
I-Epidemiology
I-MyElogenousleukemia (CML) yisifo esibi sesabekayo samangqamuzana we-hematopopoitic. Bangaphezu kuka-95% eziguli ze-CML ziphethe i-Philadelphia chromosome (PH) emangqamuzaneni egazi labo. I-Predogenis ye-CML ye-CML kanjena: I-Bcr-Abl Fusion Gene yakhelwe isiphambano phakathi kwe-Abl Proto-Oncogene (Abelson Murine leukemia (I-Abelson Murine leukemia i-chromosome 9 (9Q34) kanye ne-breakpoint Cluster Region ( I-BCR) UGene ngengalo ende ye-chromosome 22 (22Q11); Amaprotheni e-Fusion afakwe yile ntokazi ane-gene enomsebenzi we-tyrosine kinase (TK), futhi asebenze ama-ras asayina aphansi (anjenge-ras, i-pi3k, ne-jak / i-cell ukwenzeka kwe-CML. I-Bcr-abl ingenye yezinkomba ezibalulekile zokuxilonga ze-CML. Ukushintshwa okuguquguqukayo kweleveli yalo yokubhaliwe kuyinkomba ethembekile yokwahlulela kwe-leukemia futhi kungasetshenziselwa ukubikezela ukuphindaphinda kwe-leukemia ngemuva kokwelashwa.
Insungubezi
| -Yenza | I-Bcr-Abl Fusion Gene |
| VIC / Hex | Ukulawulwa Kwangaphakathi |
Amapharamitha Ezobuchwepheshe
| Ukubeka | Uketshezi: ≤-18 ℃ ebumnyameni |
| Ishalofu-impilo | Uketshezi: izinyanga eziyi-9 |
| Uhlobo lwe-Specimen | Amasampula ommono wethambo |
| Indlu edayisa insimbi | Amakhophi ayi-1000 / ml |
| Ukucacisa
| Akukho okuphambana nokuphindaphindeka kwenye i-Fusion Genes Tel-Aml1, E2A-PBX1, MLL-AF4, AML1-ETO T4, ne-PML-Rara |
| Izinsimbi ezisebenzayo | Kusetshenziswe ama-biosystems 7500 real-time PCREMS Kusetshenziswe ama-biosystem 7500 ngokushesha amasistimu we-real-time PCR I-QuantStudio® 5 Systems real-time PCREMS SLAN-96P real-time PCRS Systems I-Lightcycler®480 Uhlelo lwe-PCR yesikhathi sangempela I-LineGene 9600 Plus Real-Time Pcc Retection System I-MA-6000 I-CYRLE YOKUQHAWULA YOKUQALA I-Biorad CFX96 Uhlelo lwe-Real-Time PCR Biorad cfx opus 96 uhlelo lwe-real-time PCR |
