Ukuguqulwa kwe-KRAS 8

Ukuguqulwa kwamaphuzu ofuzo lwe-KRAS kutholwe ezinhlotsheni eziningi zesimila somuntu, cishe u-17% ~ 25% izinga lokuguquka kwesimila, 15% ~ 30% izinga lokuguquka ezigulini ezinomdlavuza wamaphaphu, 20% ~ 50% izinga lokuguquka kumdlavuza we-colorectal. iziguli.Ngenxa yokuthi iphrotheni ye-P21 efakwe ngekhodi isakhi sofuzo se-K-ras itholakala ezansi nomfula we-EGFR womzila wokusayinda, ngemva kokuguqulwa kofuzo lwe-K-ras, indlela yokubonisa engezansi ihlale isebenza futhi ayithinteki izidakamizwa eziqondiswe phezulu ku-EGFR, okuholela ekuqhubekeleni phambili. ukwanda okuyingozi kwamaseli.Ukuguqulwa kwezakhi zofuzo ze-K-ras ngokuvamile kunikeza ukumelana ne-EGFR tyrosine kinase inhibitors ezigulini ezinomdlavuza wamaphaphu kanye nokumelana nezidakamizwa ezilwa ne-EGFR ezigulini ezinomdlavuza we-colorectal.Ngo-2008, iNational Comprehensive Cancer Network (NCCN) yakhipha umhlahlandlela wokusebenza komtholampilo womdlavuza we-colorectal, owaveza ukuthi izindawo eziguqukayo ezenza ukuthi ama-K-ras asebenze atholakala ikakhulukazi kuma-codon 12 no-13 e-exon 2, futhi yancoma ukuthi zonke iziguli ezinomdlavuza osezingeni eliphezulu we-metastatic colorectal zingahlolelwa ukuguqulwa kwe-K-ras ngaphambi kokwelashwa.Ngakho-ke, ukutholwa okusheshayo nokunembile kokuguqulwa kofuzo lwe-K-ras kubaluleke kakhulu ekuqondisweni kwemithi yomtholampilo.Le khithi isebenzisa i-DNA njengesampula yokutholwa ukuze inikeze ukuhlolwa kwekhwalithi kwesimo sokuguquka, okungasiza odokotela ekuhloleni umdlavuza we-colorectal, umdlavuza wamaphaphu nezinye iziguli zesimila ezihlomula emithini eqondiwe.Imiphumela yokuhlolwa yekhithi ingeyenkomba yomtholampilo kuphela futhi akufanele isetshenziswe njengesisekelo sodwa sokwelashwa komuntu ngamunye kweziguli.Odokotela kufanele benze izinqumo ezibanzi emiphumeleni yokuhlolwa ngokusekelwe ezicini ezifana nesimo sesiguli, izinkomba zomuthi, ukusabela kokwelashwa nezinye izinkomba zokuhlola elabhorethri.