I-ROS1 Fusion Gene Mutation yabantu

I-ROS1 iyi-transmembrane tyrosine kinase yomndeni wama-insulin receptor.I-ROS1 fusion gene iye yaqinisekiswa njengolunye ufuzo olubalulekile olungelona oluncane lomshayeli womdlavuza wamaphaphu.Njengommeleli wohlobo oluncane lwamamolekyuli olusha oluhlukile, izehlakalo zofuzo oluhlanganisiwe lwe-ROS1 ku-NSCLC Cishe u-1% kuya ku-2% i-ROS1 ihlelwa kabusha yisakhi sofuzo kuma-exons ayo 32, 34, 35 kanye no-36. Ngemva kokuba ihlanganiswe nezakhi zofuzo ezifana ne-CD74, I-EZR, SLC34A2, ne-SDC4, izoqhubeka nokusebenzisa isifunda se-ROS1 tyrosine kinase.I-ROS1 kinase ecushwe ngokungavamile ingavula izindlela zokusayina ezansi nomfula njenge-RAS/MAPK/ERK, PI3K/Akt/mTOR, kanye ne-JAK3/STAT3, ngaleyo ndlela ibambe iqhaza ekwandeni, ukwahlukanisa kanye nokumetastase kwamaseli wesimila, nokudanga umdlavuza.Phakathi kwezinguquko zokuhlanganisa i-ROS1, i-CD74-ROS1 yenza cishe u-42%, i-EZR yenza cishe u-15%, i-SLC34A2 yenza cishe u-12%, kanti i-SDC4 yenza cishe u-7%.Ucwaningo luye lwabonisa ukuthi isayithi elibophezela i-ATP lesizinda se-catalytic se-ROS1 kinase kanye nesayithi elibophezela i-ATP le-ALK kinase line-homology efika ku-77%, ngakho i-ALK tyrosine kinase i-molecule encane inhibitor crizotinib nokunye kunomphumela osobala wokwelapha. ekwelapheni i-NSCLC ngokuguqulwa kwe-fusion ye-ROS1.Ngakho-ke, ukutholwa kokuguqulwa kokuhlanganiswa kwe-ROS1 kuyisisekelo nesisekelo sokuqondisa ukusetshenziswa kwezidakamizwa ze-crizotinib.