Ukuguqulwa kwe-gebheli komuntu

I-Ros1 yi-transmemmembrane tyrosine kinase yomndeni womndeni we-insulin receptor. I-ROS1 Fusion Gene iqinisekisiwe njengolunye uhlobo olubalulekile lwe-Cellong Lung Leng Cance Gene. Njengommeleli we-subtype entsha eyingqayizivele ye-molecularpe, izehlakalo ze-ros1 fusion gene e-NSCLC cishe ngo-1% kuya ku-2% ros1 ikakhulukazi ngaphansi kwezakhi zofuzo eziku-CD74, I-EZR, i-SLC34A2, ne-SDC4, izoqhubeka nokusebenzisa i-Ros1 Tyrosine Kininase Region. I-ros1 kinase esetshenziselwe i-ros1 isebenze ngendlela engajwayelekile ye-RASTream Signaling Patways efana ne-RAS / MAPK / ERK, i-PI3K / AKT3, ngaleyo ndlela ibambe iqhaza ekwandeni, nokuhlukanisa amaseli we-tumor, nokudala umdlavuza. Phakathi kwama-ros1 fusion aution, ama-CD74-ROS1 Akhawunti ama-42%, ama-akhawunti e-EZR acishe abe ngu-15%, ama-SLC34A2 ama-akhawunti cishe ama-12%, kanye ne-SDC4 afinyelela ku-7%. Ucwaningo luye lwabonisa ukuthi isiza se-ATP-esibopha isizinda se-catalytic se-ros1 kinase ye-ros1 kanye nesiza se-ATP-esibopha i-ALK KINASE sibe ne-homology ye-77%, ngakho-ke i-Alk Tyrosine KINASE ENGELCULE Invibitor Crizotinib nokunye okusobala ekwelapheni i-NSCLC nge-fusion aution ye-ros1. Ngakho-ke, ukutholwa kwe-ros1 fusion autions autions kuyisisekelo kanye nesisekelo sokuqondisa ukusetshenziswa kwezidakamizwa ze-crizotinib.