I-TEL-AML1 Fusion Gene Mutation yabantu
Igama lomkhiqizo
I-HWTS-TM016 Human TEL-AML1 Fusion Gene Mutation Detection Kit (Fluorescence PCR)
I-Epidemiology
I-acute lymphoblastic leukemia (ALL) iyisifo esivame kakhulu ebuntwaneni.Eminyakeni yamuva nje, i-acute leukemia (AL) ishintshile isuka ohlotsheni lwe-MIC (i-morphology, i-immunology, i-cytogenetics) yaba uhlobo lwe-MICM (ukwengezwa kokuhlolwa kwebhayoloji yamangqamuzana).Ngo-1994, kwatholakala ukuthi ukuhlanganiswa kwe-TEL ebuntwaneni kwakubangelwa ukudluliselwa kwe-chromosomal okungavamile t(12;21)(p13;q22) ku-B-lineage acute lymphoblastic leukemia (ALL).Kusukela kwatholakala isakhi sofuzo se-AML1 sokuhlanganisa, isakhi sofuzo se-TEL-AML1 siyindlela engcono kakhulu yokwahlulela ukubikezelwa kwezingane ezine-acute lymphoblastic leukemia.
Isiteshi
| FAM | I-TEL-AML1 yofuzo lwe-fusion |
| I-ROX | Ukulawula Kwangaphakathi |
Imingcele Yezobuchwepheshe
| Isitoreji | ≤-18℃ |
| Impilo yeshelufu | 9 izinyanga |
| Uhlobo Lwesifanekiso | isampula yomnkantsha |
| Ct | ≤40 |
| CV | <5.0% |
| LoD | 1000Amakhophi/mL |
| Ukucaciswa | Akukho ukuphinda kusebenze phakathi kwamakhithi nezinye izinhlobo zofuzo zokuhlanganisa njenge-BCR-ABL, E2A-PBX1, MLL-AF4, AML1-ETO, PML-RARa gene fusion. |
| Izinsimbi Ezisebenzayo | I-Applied Biosystems 7500 Real-Time PCR Systems Applied Biosystems 7500 Fast Real-Time PCR Systems I-QuantStudio®5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems Uhlelo lwe-PCR lwe-LightCycler®480 Real-Time I-LineGene 9600 Plus Real-Time PCR Detection System I-MA-6000 Real-Time Quantitative Thermal Cycler I-BioRad CFX96 Real-Time PCR System I-BioRad CFX Opus 96 Real-Time PCR System |
Ukugeleza komsebenzi
I-RNAprep I-Pure Blood Total RNA Extraction Kit (DP433).
