Kras 8 ukuguqulwa

Amaphoyinti aguqukayo ku-Kras Gene atholwe ezinhlotsheni eziningi ze-tumor, cishe ama-17% ~ 25% amazinga okuguqulwa kwezilinganiso ezifuywayo, ama-20% ~ 50% amanani okuguqulwa komdlavuza womdlavuza wamaphaphu iziguli. Ngoba amaprotheni e-P21 afakwe yi-K-RAS gene etholakala ezansi kwendlela ye-EGFR ukusayina, ngemuva kokuguqulwa kofuzo kwe-K-RAS, i-Downtrum generaling patway ihlala isebenza futhi ayithinteki emithini ebhekiswe e-Upfr, umphumela ukwanda okulimazayo kwamaseli. Ukuguqulwa kwezakhi zofuzo ze-K-RAS ngokuvamile kuvumela ukumelana ne-EGFR Tyrosine kinase inhibitors ezigulini ezinomdlavuza wamaphaphu kanye nokumelana nezidakamizwa ezi-anti-egfr antibody ezigulini ezinomdlavuza wezithelo. Ngo-2008, inethiwekhi yomdlavuza kazwelonke (i-NCCN) ikhiphe umhlahlandlela wokuzilolonga womdlandla womdlavuza we-colorectal, owaveza ukuthi amasayithi we-mulc adala ukuthi asebenze asetshenziswe ikakhulukazi kumakhodi ayi-12 no-13 we-Exon 2, futhi ancome lokho Zonke iziguli ezinomdlavuza we metastatic colorectal cancer zingavivinywa i-K-RAS meation ngaphambi kokwelashwa. Ngakho-ke, ukutholwa okusheshayo nokunembile kokuguqulwa kwe-K-RAS gene kubaluleke kakhulu ekuqondisweni kwemithi yezokwelapha. Le kit isebenzisa i-DNA njengesampula yokutholwa ukuhlinzeka ngohlolo lwezinto ezifanelekile zesimo sokuguqulwa, olungasiza odokotela ekuhlolweni komdlavuza we-colorectal, umdlavuza wamaphaphu nezinye iziguli ezihlomula ezidakamizweni ezihlosiwe. Imiphumela yokuhlolwa kwekhithi yesethenjwa emtholampilo kuphela futhi akufanele isetshenziswe njengesisekelo sokwelashwa komuntu ngamunye kweziguli. Odokotela kufanele benze izinqumo eziphelele ezivela kumiphumela yokuhlolwa esekelwe ezintweni ezinjengesimo sesiguli, izinkomba zezidakamizwa, impendulo yokwelashwa kanye nezinye izinkomba zokuhlola abasebenza ngelabhoratri.