Impilo yesitho sangasese sowesifazane ingaphezu kokuba khona noma ukungabikho kwamagciwane.

Indawo yangaphakathi kwesitho sangasese sowesifazane iyindawo eguquguqukayo ethonywa ukusebenzisana phakathi kwemiphakathi yamagciwane, amagciwane angosomathuba, izici zomsingathi, kanye nezindlela zokumelana namagciwane. Izinguquko ngaphakathi kwale ndawo zingase zibe nomthelela ezimweni ezifana ne-bacterial vaginosis (BV), ukutheleleka kwesitho sangasese sowesifazane okuphindaphindiwe, kanye nezinselele ekuphathweni kwemitholampilo.

Sekungamashumi eminyaka, ukuhlolwa kwempilo yesitho sangasese sowesifazane kuncike ezindleleni ezivamile ezifana ne-microscopy, ukuhlolwa kwe-pH yesitho sangasese sowesifazane, kanye nezindlela zomtholampilo ze-Amsel. Lezi zindlela zisalokhu zibalulekile ekusebenzeni kwezokwelapha; noma kunjalo, zingase zibe nemikhawulo lapho kuhlolwa izinguquko eziyinkimbinkimbi zamagciwane, amaphrofayili ahlanganisiwe amagciwane, kanye nolwazi oluhlobene nokumelana namagciwane.

Njengoba ukuqonda kwesayensi nge-microbiome yesitho sangasese sowesifazane kuqhubeka nokuthuthuka, iziqondiso zomhlaba wonke kanye nezincomo zemitholampilo kugcizelela kakhulu ukubaluleka kokucabangela ibhalansi yamagciwane kanye nokutholwa kwezifo.

Ukuze kusekelwe lesi simo sokuxilonga esishintshashintshayo,I-Macro & Micro-Test yethula i-Women's Health Advanced Nucleic Acid Detection Kit, ikhambi eliphelele lama-molecule elenzelwe ukutholaIzinhloso ezingu-20 ezifanele emitholampilo ekuhlolweni okukodwa, okunikeza ukuqonda ngama-microorganism ahlobene ne-vaginal microbiota, amagciwane asebenzisa amathuba, kanye nezimpawu zokumelana namagciwane (i-AMR).

I. Kusukela Ekutholakaleni Kwezifo Kuya Ekuhlolweni Okuphelele Kwesistimu Yemvelo Yesitho Sangasese Sowesifazane

Umbono Omusha Ngempilo Yabesifazane Yesitho Sangasese

I-bacterial vaginosis (BV) ingenye yezimbangela ezivame kakhulu zokukhishwa koketshezi lwesitho sangasese sowesifazane okungavamile kwabesifazane abaseminyakeni yokuzala, kanti ukusabalala kwalesi sifo emhlabeni wonke kulinganiselwa cishe ku-23–29%.

Ngokusho kwe-World Health Organization (WHO), i-BV ihlotshaniswa nokungalingani kwe-microbiota yesitho sangasese sowesifazane, lapho izinguquko ekwakhekeni komphakathi we-microbial zingaphazamisa indawo evamile yesitho sangasese sowesifazane.

I-American College of Obstetricians and Gynecologists (ACOG) ichaza i-BV ngendlela efanayo njengoshintsho emphakathini ojwayelekile wamagciwane esithweni sangasese sowesifazane kunokuba kube khona nje kwento eyodwa ethelelanayo.

Lokhu kuqonda kwandisa umbono wezokwelapha ngempilo yesitho sangasese sowesifazane. Nakuba ukuhlonza amagciwane afanele kusabalulekile, ukuhlola indawo ebanzi yamagciwane kunganikeza ulwazi olwengeziwe lokuqonda isimo sempilo yesitho sangasese sowesifazane.

Izindlela zamanje ziya ngokuya zidlula ekutholakaleni kwe-pathogen okuqondiswe kuyo eyodwa ziye ekuhlolweni okuphelele okucabangela:

• · Izinguquko ekulinganisweni kwamagciwane esithweni sangasese sowesifazane
• · Ukuba khona kwamagciwane ahlobene nomtholampilo
• · Izindlela ezingaba khona zokumelana namagciwane

Lokhu kuthuthuka kubonisa ukuqashelwa okwandayo kokuthi impilo yesitho sangasese sowesifazane ithonywa yiyo yonke indawo yamagciwane kunokuba kube umphumela wokutholwa okukodwa kuphela.

II. Kungani Ukuhlolwa Kwama-Molecular Okuphelele Kubalulekile

Izimo zempilo yesitho sangasese sowesifazane zingabandakanya izici eziningi ezibangela lokhu. Izimpawu ezifanayo zomtholampilo zingavela kumaphrofayili ahlukene amagciwane, futhi izinguquko zamagciwane zingathinta ukuphindaphinda kwesifo kanye nokwelashwa.

Indlela ephelele yama-molecule ingasiza ama-laboratories ukuthola ulwazi oluningiliziwe ngokuhlanganisa izilinganiso eziningi zokuxilonga ngaphakathi komsebenzi owodwa.

IIkhithi Yokuthola I-Nucleic Acid Ethuthukisiwe Yempilo Yabesifazane Ye-Macro Ne-Micro-Testihlanganisa:

1. Ukuhlolwa kwe-Vaginal Microbiota

Ihlinzeka ngolwazi oluhlobene nezici zomphakathi wamagciwane futhi isekela ukuhlolwa kwebhalansi yamagciwane esithweni sangasese sowesifazane.

2. Ukutholwa Kwezifo Ezingenamathuba

Ivumela ukutholakala ngasikhathi sinye kwamagciwane ahlobene nomtholampilo ahlobene nezimo zempilo yesitho sangasese sowesifazane.

3. Ukuhlaziywa Kophawu Lokumelana Namagciwane

Inikeza ukuqonda okwengeziwe kwama-molecule ngezakhi zofuzo ezihlobene nokumelana ukuze kusekelwe ukuphathwa kwamagciwane.

Ngokuhlanganisa la makhono, ikhambi lisiza ukuvala igebe phakathi kokuhlolwa okuvamile kanye nesidingo esikhulayo sokuqonda okuphelele kwama-molecule.

III. Ukusekela Ukuphathwa Kwama-Antimicrobial Ngokusebenzisa Ulwazi Lwama-Molecular

Ukumelana namagciwane (i-AMR) sekuyinkinga enkulu yezempilo yomphakathi emhlabeni jikelele.

Ngokusho kwe-World Health Organization (WHO), ukusetshenziswa okufanele kwamagciwane kanye namakhono okuxilonga athuthukisiwe kuyizinto ezibalulekile ekubhekaneni nezinselele ze-AMR.

Empilweni yabesifazane, ukuqonda izindlela ezingaba khona zokumelana nezifo kunganikeza ulwazi olwengeziwe lapho kuhlolwa izinketho zokwelapha kanye nokuphatha izimo eziphindaphindayo.

I-Macro & Micro-Test Women's Health Advanced Nucleic Acid Detection Kit ihlanganisa ukutholakala kwezimpawu zokumelana ezihambisana nomtholampilo:

• · I-TetM— ehlotshaniswa nezindlela zokumelana ne-tetracycline
• · i-ermB— ehlotshaniswa nezindlela zokumelana ne-macrolide-lincosamide-streptogramin
• · i-mefA— ehlotshaniswa nezindlela zokumelana nama-macrolide
• · i-bLATEM— ehlotshaniswa nezindlela zokumelana ne-beta-lactam

Ngokuhlanganisa ukuhlaziywa kwezimpawu ze-AMR nokutholwa kwamagciwane, lesi sixazululo sisekela ukuhlolwa kwama-molecule okuphelele futhi sinikeza amasu okuphatha amagciwane anolwazi.

IV. Ikhithi Yokuthola I-Nucleic Acid Ethuthukisiwe Yempilo Yabesifazane Ye-Macro & Micro-Test

Ukuhlolwa Okukodwa. Ukuqonda Okuphelele Kwempilo Yesitho Sangasese Sowesifazane.

Iklanyelwe ukuxilongwa kwama-molecule esimanje, i-Women's Health Advanced Nucleic Acid Detection Kit inikeza:

Ukutholwa Okuphelele Kwezinhloso Ezingu-20

Ukutholwa ngasikhathi sinye kwamagciwane ahlobene ne-vaginal microbiota, amagciwane angena ngengozi, kanye nezimpawu zokumelana namagciwane.

Ukuhlolwa Okuhlanganisiwe Kwe-Microbiome kanye Ne-Pathogen

Isekela ukuhlolwa kwebhalansi yamagciwane ngenkathi ihlonza amagciwane afanele emtholampilo.

Ukuqonda Kwamamolekyuli Okuhlobene Ne-AMR

Kufaka phakathi ukutholakala kwezimpawu zokumelana ze-TetM, i-ermB, i-mefA, kanye ne-bLATEM.

Ukuzwela Okuphezulu Kokuhlaziya

Umkhawulo wokutholwa (i-LOD):Amakhophi angu-800/mL

Ukuhambisana Kwepulatifomu Eguquguqukayo

Iyahambisana namapulatifomu e-PCR ajwayelekile ngesikhathi sangempela kanye nesampula-kuya-kumphumela ezenzakalelayo ngokugcweleI-Macro & Micro-Test Eudemon™ AIO800uhlelo lokuxilonga ama-molecule.

Uhlobo Lwesampula Olulula

Isampula esebenzayo:I-swab yomlomo wesibeletho/yangasese yowesifazane

Indawo Yokugcina Nokuthutha Ezinzile

Isimo sokugcina:2–25°C
Isikhathi sokuphelelwa yisikhathi:Izinyanga ezingu-12

V. Iziqondiso Zokuhlanganisa kanye Nomkhuba Wezokwelapha

Njengoba i-BV ithinta ingxenye enkulu yabesifazane abaseminyakeni yokuzala emhlabeni wonke, ukuphinda kwesifo kusalokhu kuyinselele yezokwelapha, kanye nokumelana namagciwane kuqhubeka nomthelela ekuphathweni kwezifo ezithelelanayo, izindlela zokuxilonga eziphelele ziya ngokuya zibaluleke kakhulu.

I-Macro & Micro-Test Women's Health Advanced Nucleic Acid Detection Kit imelela isizukulwane esisha sokuhlolwa kwama-molecule okwenzelwe ukuhambisana nokuqonda okuguqukayo kwempilo yesitho sangasese sowesifazane.

Ngokuhlanganisa:Ukuhlolwa kwe-Microbiome + Ukutholwa Kwe-Pathogen + Ukuhlaziywa kwe-AMR, Isixazululo sisiza amalabhorethri kanye nochwepheshe bezempilo ukuthola ukuqonda okuphelele ngempilo yesitho sangasese sowesifazane, okusekela ukuhlolwa kokuxilonga okunolwazi oluthe xaxa kanye nokwenza izinqumo zomtholampilo.

Impilo yabesifazane ayichazwa yi-microorganism eyodwa.

Kubunjwa ubudlelwano obuyinkimbinkimbi phakathi kwemiphakathi yamagciwane, izimo zezokwelapha, kanye nempilo yomuntu ngamunye.

Ngale kokutheleleka. Ukuqonda okuphelele impilo yesitho sangasese sowesifazane.