Ukusabalala kwamagciwane amelana ne-carbapenem emhlabeni wonke kuyaqhubeka nokusongela ukwelashwa okusebenzayo kwamagciwane, okwenza ukuhlonza ngokushesha izinto eziphilayo ezikhiqiza i-carbapenem kubaluleke kakhulu kunanini ngaphambili. Ukusekela ukwenziwa kwezinqumo zezokwelapha ngesikhathi esifanele kanye nokuqapha ukumelana namagciwane (i-AMR),Ukuhlolwa Okukhulu Nokuncaneiyaziqhenya ngokwethulaIkhithi Yokuthola I-CarbapenemasengeIsitifiketi se-IVDR, ukuhambisana nezidingo eziqinile zoMthethonqubo Wokuxilongwa Kwe-European In Vitro (EU 2017/746).

Yakhelwe ukuthola ama-molecule ngokushesha nangokunembile ama-gene ayisithupha abaluleke kakhulu emtholampilo e-carbapenemase—I-KPC, i-NDM, i-OXA-48, i-OXA-23, i-VIM kanye ne-IMP—ukuhlolwa kunikeza amalabhorethri ikhambi elithembekile lokulawula ukutheleleka, ukuphathwa kwamagciwane kanye nokuphathwa kweziguli okuthuthukisiwe. Ikhambi liyatholakala kokubili kumapulatifomu avamile e-PCR ngesikhathi sangempela kanye ne-othomathikhi ngokugcweleI-Eudemon^TMI-AIO800Isihlaziyi Sokukhulisa I-Nucleic Acid, okuvumela ukuthunyelwa okuguquguqukayo kuzo zonke izindawo zelebhu ezahlukahlukene.

Kungani Kubalulekile Ukuthola I-Carbapenema

Ama-Carbapenems ahlala engenye yezindlela ezibaluleke kakhulu zokwelapha izifo ezibangelwa amagciwane ezinzima. Kodwa-ke, ukuvela okwandayo kwezinto eziphilayo ezikhiqiza i-carbapenemase kuye kunciphisa kakhulu ukusebenza kwazo kwezokwelapha.

Ngokusho kwe-Inhlangano Yezempilo Yomhlaba (i-WHO), ukumelana namagciwane kuphakathi kwezinsongo ezihola phambili empilweni yomphakathi emhlabeni, kuyilapho ama-Enterobacteriale (CRE) angamelana ne-carbapenem abhekwa njengenye yezifo ezibaluleke kakhulu ezidinga ukubhekwa okuqhubekayo nokuxilongwa okusheshayo.

Ukuhlonza kwasekuqaleni izakhi zofuzo ze-carbapenemase kwenza ochwepheshe bezempilo bakwazi:

• · Qala ukwelashwa okufanelekile okulwa namagciwane ngokushesha
• · Sekela izinhlelo zokuphatha ama-antimicrobial
• · Sebenzisa izinyathelo zokuvimbela nokulawula ukutheleleka ngesikhathi esifanele
• · Qapha ukusabalala kwezidalwa ezimelana nezifo ezikhungweni zezempilo

Ukuqondisa ama-Carbapenema afaneleka kakhulu emtholampilo

Ukuhlolwa kwe-Macro & Micro-Test kuthola ngasikhathi sinye izakhi zofuzo eziyisithupha ezinkulu zokumelana ezibangela iningi lezifo ezibaluleke kakhulu ezimelana ne-carbapenem.

Ukuhlolwa Okusheshayo kwe-PCR Kwezinqumo Zezokwelapha Eziqinisekile

Uma kuqhathaniswa nezindlela ezivamile ze-phenotypic, ukutholwa kwama-molecule okusekelwe ku-PCR kunikeza ukuzwela okuphezulu, ukucacisa kanye nesikhathi sokushintsha. Ukuhlonza ngokushesha izakhi zofuzo zokumelana kusiza odokotela ukuba benze izinqumo zokwelapha ezisekelwe ebufakazini ngenkathi kusekelwa ukulawulwa kokutheleleka esibhedlela kanye nokuqapha ukumelana namagciwane.

Isixazululo Sokuthola I-Carbapenemase Esiqinisekiswe yi-IVDR

-Sukutholwa okusheshayo kweI-KPC, i-NDM, i-OXA-48, i-OXA-23, i-VIM kanye ne-IMPezinhlafunweni zabantu nasezindaweni ezihlukanisiwe zamasiko;

-Ukucaciswa okuphezulu okungenakho ukusabela okuxubile kuma-pathogen angahlosiwe noma izakhi zofuzo zokumelana;

-Ukuzwela okuphezulu kuze kufike ku100 CFU/mL or Amakhophi angu-500/mL; 

-Ukuhambisana Okubanzi nge-ABI 7500, i-SLAN-96P kanye nezinye izinhlelo ze-PCR zesikhathi sangempela ezivamile;

Ukuzenzakalela okugcwele kuvuliweI-Eudemon^TM I-AIO800

II-AIO800ihlanganisa ukulungiswa kwesampula, ukukhishwa kwe-nucleic acid, ukukhulisa kanye nokuchazwa kwemiphumela ibe yipulatifomu eyodwa encane, iletha ukuhlolwa kwama-molecule okusheshayo nokuthembekile ngesikhathi esincane sokusebenza.

-Isampula Yokuphendula Umsebenzi Ozenzakalelayo Ngokugcwele.

-Imiphumela esheshayo cishe ngemizuzu engama-80.

-Uhlelo lokulawula ukungcola oluhlanganisiwe luqinisekisa imiphumela enembile nethembekile.

Ukusekela Ukuphathwa Okungcono Kwama-Antimicrobial

Ngesitifiketi se-IVDR, i-Macro & Micro-Test ikhombisa ukuzibophezela kwayo ekuhlinzekeni izixazululo zokuxilonga ama-molecule ezisezingeni eliphezulu kuma-laboratory kulo lonke elaseYurophu nasemhlabeni jikelele.

Isixazululo Sokuthola I-Carbapenemase esiqinisekiswe yi-IVDR senza abahlinzeki bezempilo bakwazi ukuqinisa ukuqapha ukumelana namagciwane, bathuthukise amasu okulawula ukutheleleka futhi banikeze izinqumo zokwelapha ezinembile kakhulu ezigulini ezibhekene nokutheleleka kwamagciwane okumelana nemithi eminingi.

Ukuxilongwa Okunembile Kwakha Ikusasa Elingcono.

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