Muva nje,I-CDC yaseShayina Njalo Ngevikiishicilele isihloko esibalulekile socwaningo esichaza uphenyo lwe-epidemiological kanye ne-etiological lokuqubuka kwe-acute gastroenteritis okubangelwa yi-Group C rotavirus (RVC) esikoleni samabanga aphansi eLuzhou, eSifundazweni saseSichuan, ngo-Okthoba 2025. Okuphawulekayo ukuthi i-Macro & Micro-Test's high-throughput targeted pathogen capture kit (probe-capture) kanye nobuchwepheshe bokulandelela i-whole-genome enrichment sequencing budlale indima ebalulekile ophenyweni. Ngokuvumela ukuhlonza i-pathogen okunembile kanye nokuhlukaniswa okuphelele kwe-genomic, ubuchwepheshe buhlinzeke ubufakazi obubalulekile besayensi bokuqinisekisa ukuqubuka okusheshayo, ukulandelela umthombo oqondile, kanye nokulawula ukuqubuka okuphumelelayo.
Ukuqubuka Okungazelelwe: Ukuqubuka Kwe-RVC Okubikiwe Okokuqala eNingizimu-ntshonalanga yeShayina
Ngomhlaka-15 Okthoba 2025, ukuqubuka kwesifo sofuba esiswini kwenzeka esikoleni samabanga aphansi eLuzhou. Lesi sikole sasinabafundi nabasebenzi abangu-1,943, kanti amacala angu-32 abikiwe, okuhlanganisa namacala angu-6 aqinisekiswe yilabhorethri kanye namacala angu-26 atholakale emtholampilo, okwaholela ezingeni lokuhlasela eliphelele elingu-1.65%. Ukuqubuka kwafinyelela phezulu phakathi kuka-15 no-16 Okthoba, kanti iBanga lesi-7, iBanga lesi-5 lathola izinga lokuhlasela eliphakeme kakhulu (23.08%). Iningi leziguli kwakungabantwana abaseminyakeni yesikole (ubudala obuphakathi: iminyaka eyi-10), ababebonakala kakhulu ngokuhlanza (65.62%), uhudo (46.87%), kanye nobuhlungu besisu (37.50%). Izimpawu zivame ukuhlala izinsuku ezingu-1-3, futhi zonke iziguli zalulama ngaphandle kwezinkinga ezinkulu.
Uphenyo lwezifo luveze ukuthi leli cala liyinkomba yomfana oneminyaka engu-11 ubudala eBangeni lesi-7, iBanga lesi-5. Udadewabo omncane wayenezimpawu ezifanayo ngaphambi kwakhe, okubonisa ukuthi ukutheleleka kwasekhaya kungumthombo wokuqala. Ukuphathwa okwanele kokuhlanza ekhempasini—okuhlanganisa ukushanela ngqo nokulahla ngaphandle kokubulala amagciwane ngesikhathi noma ukuhlukaniswa kwendawo—kuhlanganiswe nokungahlanzeki kwezandla phakathi kwabafundi, cishe kwasiza ekusabalaliseni ukutheleleka okwengeziwe. Amakilasi amaningi athintekile ayephakathi kwesitezi sesibili nesesihlanu kanye nezindlu zangasese zabesilisa eziseduze, okubonisa ukuthi kokubili i-aerosol kanye nokutheleleka kokuxhumana kungenzeka kube nomthelela ekusabalaleni.
Uphenyo lwaba yinselele kakhulu ngoba ukuhlolwa okuvamile kwezifo, okuhlanganisa nokuhlolwa kwe-norovirus kanye ne-Group A rotavirus, kwaveza imiphumela emibi, okubonisa ukuthi i-pathogen engavamile yiyo eyabangela.
Ukuxilongwa Kwemvelaphi: Ukulandelelana Kwe-Genome Ephelele Kwe-Macro & Micro-Test Kukhomba Icala
Ukuhlolwa kokuqala kwe-norovirus kwaba negative. I-Luzhou CDC yabe isisebenzisa i-multiplex gastrointestinal pathogen real-time PCR assay ekwazi ukuthola ngasikhathi sinye amagciwane angu-28, okuhlanganisa amagciwane angu-8, amagciwane angu-17, kanye nama-parasite angu-3, ukuze kuhlolwe amasampula emitholampilo ayisishiyagalombili. Ngomhlaka-17 Okthoba, amasampula ayisithupha ahlolwe ukuthi ane-Group C rotavirus, athola ngempumelelo i-pathogen eyimbangela.
Ukuze baqhubeke nokulandelela umthombo wokuqubuka kwalesi sifo, abaphenyi benze kokubili ukulandelana kwe-nanopore metagenomic kanye nokulandelelana kwe-probe-capture whole-genome enrichment kwe-Macro & Micro-Test kumasampula amahlanu amahle. Le ndlela iphumelele ekukhiqizeni ama-genome sequences amahlanu aphelele e-RVC (SC01–SC05). Isu elihlanganisiwe lokuhlola okusheshayo kwe-multiplex PCR okulandelwa ukulandelana kwe-whole-genome okunesinqumo esiphezulu linikeze ukwesekwa okuqinile kobuchwepheshe be-epidemiology enembile yama-molecule kanye nokulandelela umthombo.
Ukuqonda Kwesayensi: Ukuhlonza Okokuqala kwe-M2 Genotype eNingizimu-ntshonalanga yeShayina
Ngokusekelwe kudatha ye-whole-genome esezingeni eliphezulu ekhiqizwe kusetshenziswa ubuchwepheshe be-Macro & Micro-Test, ithimba locwaningo libike imiphumela eminingana ebalulekile yesayensi:
Ukuqinisekiswa kokuqubuka kwesifo se-monoclonal:Zonke izinhlobo ezinhlanu zamagciwane zabelana nge-genotype efanayo ye-whole-genome (G4-P[2]-I2-R2-C2-M2-A2-N2-T2-E2-H2), enomehluko we-nucleotide single polymorphism (SNP) ongu-0–1 kuphela, okubonisa ngokusobala ukuthi ukuqubuka kwalesi sifo kuvela eketangeni elilodwa lokudlulisela.
Ukutholwa kohlobo lwe-M2:Ukuhlaziywa kwe-phylogenetic kwembule ukuthi izinhlobo ze-Luzhou RVC zazingezohlobo lwe-M2 kunokuba uhlobo lwe-M3 olwalubhekwa njengoluvame kakhulu phakathi kwezinhlobo ze-RVC zaseShayina. Lokhu okutholakele kuphonsela inselelo ukuqonda okuvamile kokusatshalaliswa kohlobo lwe-RVC eShayina futhi kuqinisekisa ukuvela kohlobo lwe-M2 eningizimu-ntshonalanga yeShayina.
Ubufakazi bezixhumanisi zokudlulisela emhlabeni jikelele:Ukuqhathaniswa kwe-genome ephelele kubonise ukufana okuphezulu kwezakhi zofuzo phakathi kwezinhlobo zeLuzhou nezinhlobo ze-RVC ezibikwe ngaphambilini eYunnan (2025), eNovosibirsk, eRussia (2017), kanye nase-Italy (2012), okuphakamisa ukuthi kukhona inethiwekhi yokudlulisela esebenzayo yase-Eurasia.
Imiphumela Yokuvimbela Nokulawula: Ukutholwa Kwasekusha Nokungenelela Okusheshayo Kubalulekile
Ngemva kokuhlonza amagciwane, i-Luzhou CDC yaqala ngokushesha izinyathelo zokulawula eziphelele, okuhlanganisa ukuhlukaniswa kwamacala, ukubulala amagciwane endaweni ezungezile, ukuphathwa kokuhlanza okujwayelekile, kanye nokumiswa kwesigaba sesikhashana. Ukuqubuka kwalesi sifo kwanqotshwa ngempumelelo esikhathini esisodwa sokufukamela, kungekho macala engeziwe abikiwe ngemuva komhlaka-21 Okthoba.
Lolu phenyo luphinde lunikeze isifundo esibalulekile sezempilo yomphakathi: ngokuqubuka kwe-gastroenteritis ehlanganisiwe okubonakala kungenalo igciwane le-rotavirus leQembu A kanye ne-norovirus, i-rotavirus yeQembu C kanye namanye ama-rotavirus angewona aweQembu A kufanele afakwe ekuhlolweni okuvamile kokuxilonga.
Lolu cwaningo lumelela ukuqubuka kokuqala okubikiwe kwe-Group C rotavirus eningizimu-ntshonalanga yeShayina kanye nokuhlonza kokuqala kwe-genotype ye-M2 esifundeni, okwandisa ukuqonda kwamanje kwe-RVC epidemiology eMpumalanga Asia. Kulolu cwaningo, ikhambi elihlanganisiwe le-Macro & Micro-Test elihlanganisa ukuhlolwa kwe-multiplex PCR kanye nokulandelana kokucebisa i-genome yonke kubonise inani elibalulekile elisebenzayo ngokuvumela ukuhlonza i-pathogen okusheshayo kanye nokulandelela umthombo wama-molecule onesisombululo esiphezulu, okuhlinzeka ngohlaka lobuchwepheshe oluphindaphindwayo lokuphenya okunembile kanye nokulawula ukuqubuka kwezifo ezithathelwanayo esikhathini esizayo.
Isikhathi sokuthunyelwe: Julayi-30-2026