Ukutholwa Kwesifo Sofuba kanye Ne-MDR-TB Ngesikhathi Esifanayo

Isifo sofuba (TB), esibangelwa yisifo sofuba iMycobacterium(I-MTB), isalokhu iwusongo lwezempilo emhlabeni jikelelekanye nokwandaukumelana nokhiyeTBizidakamizwa ezifana ne-Rifampicinn (RIF) kanye ne-Isoniazid (INH)kubaluleke kakhulu njengobaisithiyo emhlabeni jikeleleTB imizamo yokulawula.Okusheshayo nokunembileukuhlolwa kwama-moleculeye-TB kanye nokumelana ne-RIF&I-INH inconywa yi-WHO ukuthitholaiziguli ezinegciwanengesikhathi esifanelefuthibanikeze ukwelashwa okufanele ngesikhathi esifanele.

Izinselele

Kulinganiselwa ukuthi abantu abayizigidi eziyi-10.6wagula ngesifo sofuba ngo-2022, okuholela ku-kulinganiselwa ukuthi bangu-1.3 million abantu abashonile, kude kakhulu nengqophamlando ka-2025 yeSu Lokuqeda Isifo Sofuba

I-TB engazweli emithini, ikakhulukazi i-MDR-TB (engazweli ku-RIF)&INH),kuthinta kakhulu umhlaba wonke TB ukwelashwakanye nokuvimbela.

Ukuxilongwa okusheshayo ngesikhathi esisodwa kwe-TB kanye ne-RIF/INH ukumelanakudingeka ngokusheshangaphambilinifuthiukwelashwa okuphumelelayo kakhulu uma kuqhathaniswangeimiphumela yokuhlolwa kokuzwela kwezidakamizwa ebambezelekile.

OkwethuIsixazululo

UMarco kanye nokuhlolwa kweMicroIkhithi Yokuthola Ukumelana Ne-TB Eyi-3-in-1 Yokuthola Ukutheleleka Nge-TB/RIF kanye Ne-NIHkwenza kube lula ukuxilongwa okuphumelelayo kwe-I-TB kanye ne-RIF/INH ekutholeni okukodwa.

Ubuchwepheshe bokuncibilikisa i-Melting curve bubona ngesikhathi esisodwa i-TB kanye ne-MDR-TB.

Ukutholwa kwe-TB/MDR-TB okungu-3-in-1 okunquma ukutheleleka kwe-TB kanye nokumelana nemithi yokuqala ebalulekile (i-RIF/INH) kwenza ukwelashwa kwe-TB kube ngesikhathi nangokunembile.

I-Mycobacterium Tuberculosis Nucleic Acid kanye ne-Rifampicin, Ikhithi Yokuthola Ukumelana ne-Isoniazid (I-Melting Curve)

Uphumelela ekuhlolweni kwe-TB okuphindwe kathathu (ukutheleleka kwe-TB, ukumelana ne-RIF kanye ne-NIH) ngokutholwa okukodwa!

Umphumela osheshayo: Itholakala emahoreni angu-2-2.5 ngokuhumusha okuzenzakalelayo kwemiphumela okunciphisa ukuqeqeshwa kobuchwepheshe kokusebenza;

Isampula Yokuhlola: isikhwehlela, isiko eliqinile, isiko eliwuketshezi

Ukuzwela Okuphezulu: Amabhaktheriya angu-25/mL e-TB, amabhaktheriya angu-200/mL e-RIF amelana namagciwane, amabhaktheriya angu-400/mL e-INH amelana namagciwane, okuqinisekisa ukutholakala okuthembekile ngisho noma kunemithwalo ephansi yamabhaktheriya.

Izinhloso Eziningi: I-TB-IS6110; Ukumelana ne-RIF-rpoB (507~503); Ukumelana ne-INH-InhA, AhpC, katG 315;

Ukuqinisekiswa Kwekhwalithi: Ukulawulwa kwangaphakathi kokuqinisekiswa kwekhwalithi yesampula ukuze kuncishiswe okungekuhle okungamanga;

Ukuhambisana Okubanziy: Ukuhambisana nezinhlelo eziningi ze-PCR ezijwayelekile ukuze kufinyeleleke kabanzi elabhorethri (i-Bio-Rad CFX96, i-SLAN-96P/96S, i-Bioer Quantgene 9600);

Ukuthobela Iziqondiso ze-WHO: Ukunamathela eziqondisweni ze-WHO zokuphathwa kwesifo sofuba esingamelana nemithi, ukuqinisekisa ukuthembeka nokufaneleka emikhubeni yezokwelapha.