Ukutholwa Kwesifo Sofuba kanye Ne-MDR-TB Ngesikhathi Esifanayo

Isifo sofuba (TB), nakuba singavinjelwa futhi selapheka, sisalokhu siwusongo empilweni yomhlaba wonke. Abantu abalinganiselwa ezigidini ezingu-10.6 bagula ngesifo sofuba ngo-2022, okwaholela ekufeni okulinganiselwa ezigidini ezingu-1.3 emhlabeni wonke, okukude kakhulu nesinyathelo sika-2025 seSu Lokuqeda Isifo Sofuba yi-WHO. Ngaphezu kwalokho, ukumelana nemithi yokulwa ne-TB, ikakhulukazi i-MDR-TB (emelana ne-RIF kanye ne-INH), kuya ngokuya kuyinselele ekwelashweni nasekuvinjelweni kwe-TB emhlabeni jikelele.

Ukuxilongwa kwe-TB kanye nokungamelani nemithi yokulwa ne-TB okusebenzayo nokunembile kuyiSIHLUTHULELO sempumelelo yokwelashwa nokuvimbela i-TB.

Isixazululo Sethu

UMarco kanye nokuhlolwa kweMicroUkutholwa kwe-TB okungu-3-in-1 kokutheleleka kwe-TB/RIF kanye nokumelana ne-NIHIkhithi Yokuthola ivumela ukuxilongwa okuphumelelayo kwe-TB kanye ne-RIF/INH ekutholakaleni okukodwa ngobuchwepheshe be-Melting curve.

Ukutholwa kwe-TB/MDR-TB okungu-3-in-1 okunquma ukutheleleka kwe-TB kanye nokumelana nemithi yokuqala ebalulekile (i-RIF/INH) kwenza ukwelashwa kwe-TB kube ngesikhathi nangokunembile.

I-Mycobacterium Tuberculosis Nucleic Acid kanye ne-Rifampicin, Ikhithi Yokuthola Ukumelana ne-Isoniazid (I-Melting Curve)

Uphumelela ekuhlolweni kwe-TB okuphindwe kathathu (ukutheleleka kwe-TB, ukumelana ne-RIF kanye ne-NIH) ngokutholwa okukodwa!

Umphumela osheshayo:Itholakala emahoreni angu-2-2.5 ngokuhumusha okuzenzakalelayo kwemiphumela okunciphisa ukuqeqeshwa kobuchwepheshe kokusebenza;

Isampula Yokuhlola:Isikhwehlela, i-LJ Medium, i-MGIT Medium, i-Bronchial Lavage Fluid;

Ukuzwela Okuphezulu:Amabhaktheriya angu-110/mL e-TB, amabhaktheriya angu-150/mL e-RIF, amabhaktheriya angu-200/mL e-INH, okuqinisekisa ukutholakala okuthembekile ngisho noma kunemithwalo ephansi yamabhaktheriya.

Izinhloso Eziningi:I-TB-IS6110; Ukumelana ne-RIF-rpoB (507~533); Ukumelana ne-INH-InhA, AhpC, katG 315;

Ukuqinisekiswa Kwekhwalithi:Ukulawulwa kwangaphakathi kokuqinisekiswa kwekhwalithi yesampula ukuze kuncishiswe okungekuhle okungamanga;

Ukuhambisana Okubanziy: Ukuhambisana nezinhlelo eziningi ze-PCR ezijwayelekile ukuze kufinyeleleke kabanzi elabhorethri (SLAN-96P, BioRad CFX96);

Ukuthobela Iziqondiso ze-WHO:Ukunamathela eziqondisweni ze-WHO zokuphathwa kwesifo sofuba esingamelana nemithi, ukuqinisekisa ukuthembeka nokufaneleka emikhubeni yezokwelapha.