Umqondo wesimila
Isimila isilwane esisha esakhiwe ukwanda okungavamile kwamangqamuzana emzimbeni, okuvame ukubonakala njengesisindo sezicubu ezingavamile (isigaxa) engxenyeni yendawo yomzimba. Ukwakheka kwamathumba kuwumphumela wokuphazamiseka okukhulu kokulawulwa kokukhula kwamangqamuzana ngaphansi kwesenzo sezici ezihlukahlukene ze-tumorigenic. Ukwanda okungavamile kwamaseli okuholela ekwakhekeni kwesimila kubizwa ngokuthi ukwanda kwe-neoplastic.
Ngo-2019, iCancer Cell ishicilele isihloko muva nje. Abacwaningi bathole ukuthi i-metformin ingavimbela ngokuphawulekayo ukukhula kwesimila esimweni sokuzila ukudla, futhi baphakamisa ukuthi indlela ye-PP2A-GSK3β-MCL-1 ingase ibe inhloso entsha yokwelashwa kwesimila.
Umehluko omkhulu phakathi kwe-benign tumor kanye ne-malignant tumor
I-Benign tumor: ukukhula kancane, i-capsule, ukukhula kokuvuvukala, ukushelela kuye ekuthinteni, umngcele ocacile, akukho metastasis, ukubikezela okuhle ngokuvamile, izimpawu zokucindezelwa kwendawo, ngokuvamile akukho umzimba wonke, ngokuvamile akubangeli ukufa kweziguli.
Isimila esiyingozi (umdlavuza): ukukhula ngokushesha, ukukhula okuhlaselayo, ukunamathela ezicutshini ezizungezile, ukungakwazi ukunyakaza lapho kuthintwa, umngcele ongacacile, i-metastasis elula, ukuphindaphinda kalula ngemva kokwelashwa, umkhuhlane ophansi, ukungakuthandi ukudla ekuqaleni, ukuncipha kwesisindo, ukuwohloka okukhulu, i-anemia kanye nomkhuhlane ekupheleni kwesikhathi, njll. Uma kungelashwa ngesikhathi, ngokuvamile kuholela ekufeni.
"Ngenxa yokuthi ama-benign tumors kanye nama-tumor amabi awagcini nje ngokubonakala okuhlukile emitholampilo, kodwa okubaluleke nakakhulu, ukubikezela kwabo kuhlukile, ngakho-ke uma uthola isigaxa emzimbeni wakho kanye nezimpawu ezingenhla, kufanele ufune iseluleko sezokwelapha ngesikhathi."
Ukwelashwa komuntu ngamunye kwesimila
I-Human Genome Project kanye ne-International Cancer Genome Project
I-Human Genome Project, eyethulwa ngokusemthethweni e-United States ngo-1990, ihlose ukuvula wonke amakhodi ezakhi zofuzo ezingaba ngu-100,000 emzimbeni womuntu futhi idwebe i-spectrum yezakhi zofuzo zomuntu.
Ngo-2006, i-International Cancer Genome Project, eyethulwe ngokuhlanganyela amazwe amaningi, ingolunye ucwaningo lwesayensi olukhulu olulandela i-Human Genome Project.
Izinkinga eziyinhloko ekwelashweni kwesimila
Individualized diagnosis and treatment = Individualized diagnosis + imishanguzo ehlosiwe
Ezigulini eziningi ezihlukene eziphethwe isifo esifanayo, indlela yokwelapha iwukusebenzisa umuthi ofanayo nesikali esivamile, kodwa empeleni, iziguli ezihlukene zinomehluko omkhulu emiphumeleni yokwelashwa nokusabela okungekuhle, futhi ngezinye izikhathi lo mehluko ubulala ngisho nokufa.
Ukwelashwa kwezidakamizwa okuhlosiwe kunezici zokubulala okukhetha kakhulu kwamaseli esimila ngaphandle kokubulala noma okungajwayelekile nje ukulimaza amaseli avamile, anemiphumela engemihle emincane uma kuqhathaniswa, ethuthukisa ngempumelelo ikhwalithi yempilo nomthelela wokwelapha weziguli.
Ngenxa yokuthi ukwelapha okuhlosiwe kuklanyelwe ukuhlasela ama-molecule athile okuqondiwe, kuyadingeka ukuthi kutholwe izakhi zofuzo zesimila futhi kutholwe ukuthi iziguli zinakho yini okuhlosiwe okuhambisanayo ngaphambi kokuthatha izidakamizwa, ukuze kube nomphumela wazo wokwelapha.
Ukutholwa kofuzo lwesimila
Ukutholwa kofuzo lwesimila kuyindlela yokuhlaziya nokulandelanisa i-DNA/RNA yamaseli wesimila.
Ukubaluleka kokutholwa kofuzo lwesimila kuwukuqondisa ukukhethwa kwezidakamizwa zokwelashwa kwezidakamizwa (izidakamizwa ezihlosiwe, ama-immune checkpoint inhibitors kanye ne-AIDS entsha, ukwelashwa sekwephuzile), kanye nokubikezela ukubikezela nokuphinda kwenzeke.
Izixazululo zinikezwe i-Acer Macro & Micro-Test
Ikhithi Yokuthola Ukuguquka Kwezakhi Zomuntu I-EGFR Gene 29 (Fluorescence PCR）
Isetshenziselwa ukutholwa kwekhwalithi yokuguqulwa okujwayelekile ku-exon 18-21 yofuzo lwe-EGFR ezigulini zomdlavuza wamaphaphu ongewona omncane weseli ku-vitro.
1. Ukwethulwa kokulawulwa kwekhwalithi yereferensi yangaphakathi kusistimu kungaqapha ngokugcwele inqubo yokuhlola futhi kuqinisekise ikhwalithi yokuhlola.
2. Ukuzwela okuphezulu: izinga lokuguqulwa elingu-1% lingatholwa ngokuzinza ngemuva kwesisombululo sokusabela se-nucleic acid sohlobo lwasendle esingu-3ng/μL.
3. Ukucaciswa okuphezulu: akukho ukusabela okuphambene nemiphumela yokutholwa kwe-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
I-KRAS 8 Mutations Detection Kit (Fluorescence PCR)
Izinhlobo eziyisishiyagalombili zokuguqulwa kwamakhodoni 12 kanye no-13 ofuzo lwe-K-ras asetshenziselwa ukutholwa kwekhwalithi ye-DNA ekhishwe ezigabeni ze-pathological ezishumekwe ngupharafini ku-vitro.
1. Ukwethulwa kokulawulwa kwekhwalithi yereferensi yangaphakathi kusistimu kungaqapha ngokugcwele inqubo yokuhlola futhi kuqinisekise ikhwalithi yokuhlola.
2. Ukuzwela okuphezulu: izinga lokuguqulwa elingu-1% lingatholwa ngokuzinza ngemuva kwesisombululo sokusabela se-nucleic acid sohlobo lwasendle esingu-3ng/μL.
3. Ukucaciswa okuphezulu: akukho ukusabela okuphambene nemiphumela yokutholwa kwe-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
I-ROS1 Fusion Gene Mutation Detection Kit yomuntu (Fluorescence PCR)
Isetshenziselwa ukuthola ngokufanelekile izinhlobo eziyi-14 zokuguqulwa kofuzo lwe-ROS1 ezigulini ezinomdlavuza wamaphaphu ongewona omncane ku-vitro.
1. Ukwethulwa kokulawulwa kwekhwalithi yereferensi yangaphakathi kusistimu kungaqapha ngokugcwele inqubo yokuhlola futhi kuqinisekise ikhwalithi yokuhlola.
2. Ukuzwela okuphezulu: amakhophi angu-20 wokuguqulwa kwe-fusion.
3. Ukucaciswa okuphezulu: akukho ukusabela okuphambene nemiphumela yokutholwa kwe-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
I-EML4-ALK Fusion Gene Mutation Detection Kit yomuntu (Fluorescence PCR)
Isetshenziselwa ukuthola ngokufanelekile izinhlobo eziyi-12 zokuguqulwa kofuzo lwe-EML4-ALK ezigulini zomdlavuza wamaphaphu ongewona omncane we-vitro.
1. Ukwethulwa kokulawulwa kwekhwalithi yereferensi yangaphakathi kusistimu kungaqapha ngokugcwele inqubo yokuhlola futhi kuqinisekise ikhwalithi yokuhlola.
2. Ukuzwela okuphezulu: amakhophi angu-20 wokuguqulwa kwe-fusion.
3. Ukucaciswa okuphezulu: akukho ukusabela okuphambene nemiphumela yokutholwa kwe-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
I-Human BRAF Gene V600E Mutation Detection Kit (Fluorescence PCR)
Isetshenziselwa ukuthola ngokufanelekile ukuguqulwa kofuzo lwe-BRAF V600E kumasampula ezicubu ezishunyekiwe zikapharafini zemelanoma yomuntu, umdlavuza we-colorectal, umdlavuza wegilo kanye nomdlavuza wamaphaphu in vitro.
1. Ukwethulwa kokulawulwa kwekhwalithi yereferensi yangaphakathi kusistimu kungaqapha ngokugcwele inqubo yokuhlola futhi kuqinisekise ikhwalithi yokuhlola.
2. Ukuzwela okuphezulu: izinga lokuguqulwa elingu-1% lingatholwa ngokuzinza ngemuva kwesisombululo sokusabela se-nucleic acid sohlobo lwasendle esingu-3ng/μL.
3. Ukucaciswa okuphezulu: akukho ukusabela okuphambene nemiphumela yokutholwa kwe-DNA yomuntu yohlobo lwasendle nezinye izinhlobo eziguqukayo.
| Into No | Igama Lomkhiqizo | Ukucaciswa |
| I-HWTS-TM006 | I-EML4-ALK Fusion Gene Mutation Detection Kit yomuntu (Fluorescence PCR) | Izivivinyo ezingama-20/ikhithi Izivivinyo ezingama-50/ikhithi |
| I-HWTS-TM007 | I-Human BRAF Gene V600E Mutation Detection Kit (Fluorescence PCR) | 24 ukuhlolwa/ikhithi 48 ukuhlolwa/ikhithi |
| I-HWTS-TM009 | I-ROS1 Fusion Gene Mutation Detection Kit yomuntu (Fluorescence PCR) | Izivivinyo ezingama-20/ikhithi Izivivinyo ezingama-50/ikhithi |
| I-HWTS-TM012 | Ikhithi Yokuthola Ukuguquka Kwezakhi Zomuntu I-EGFR Gene 29 (Fluorescence PCR） | Izivivinyo eziyi-16/ikhithi 32 ukuhlolwa/ikhithi |
| I-HWTS-TM014 | I-KRAS 8 Mutations Detection Kit (Fluorescence PCR) | 24 ukuhlolwa/ikhithi 48 ukuhlolwa/ikhithi |
| I-HWTS-TM016 | Ikhithi Yokuthola Ukuguqulwa Kwezakhi Zofuzo Yomuntu ye-TEL-AML1 (i-Fluorescence PCR) | 24 ukuhlolwa/ikhithi |
| I-HWTS-GE010 | Ikhithi Yokuthola Ukuguqulwa Kwezakhi Zofuzo Yomuntu I-BCR-ABL (i-Fluorescence PCR) | 24 ukuhlolwa/ikhithi |
Isikhathi sokuthumela: Apr-17-2024