● I-Oncology
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Ukuguqulwa Kwezakhi Zofuzo Ze-PML-RARA Zomuntu
Le khithi isetshenziselwa ukuthola i-PML-RARA fusion gene esezingeni eliphezulu kumasampula omnkantsha womuntu ngaphandle kokusebenzisa i-vitro.
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Ukuguqulwa Kwezakhi Zofuzo Ze-TEL-AML1 Zomuntu
Le khithi isetshenziselwa ukuthola i-TEL-AML1 fusion gene esezingeni eliphezulu kumasampula omnkantsha womuntu ngaphandle kokusebenzisa i-vitro.
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Ukuguqulwa kweGene V600E yomuntu
Le khithi yokuhlola isetshenziselwa ukuthola ngokwekhwalithi ukuguqulwa kwezakhi zofuzo ze-BRAF V600E kumasampula ezicubu ezifakwe i-paraffin ze-melanoma yomuntu, umdlavuza we-colorectal, umdlavuza we-thyroid kanye nomdlavuza wamaphaphu ngaphandle kokusebenzisa i-vitro.
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Ukuguqulwa Kwezakhi Zofuzo Ze-BCR-ABL Ze-Human Fusion
Le khithi ifaneleka ukuthola ama-isoform e-p190, p210 kanye ne-p230 e-BCR-ABL fusion gene kumasampula omnkantsha womuntu.
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Izinguquko ze-KRAS 8
Le khithi yenzelwe ukutholwa kwezinguquko ezingu-8 ezishintshashintshayo kuma-codon 12 no-13 e-K-ras gene ku-DNA ekhishwe ezingxenyeni ze-pathological ezifakwe i-paraffin yomuntu.
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Izinguquko ze-Gene 29 ze-EGFR zomuntu
Le khithi isetshenziselwa ukuthola ngokuzenzakalelayo izinguquko ezivamile kuma-exons 18-21 esakhini se-EGFR kumasampula avela ezigulini zomdlavuza wamaphaphu ezingezona ezincane zabantu.
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Ukuguqulwa Kwezakhi Zofuzo Zokuhlanganiswa Kwe-ROS1 Yabantu
Le khithi isetshenziselwa ukuthola izinhlobo ezingu-14 ze-ROS1 fusion gene mutations kumasampula omdlavuza wamaphaphu angewona amancane kubantu (Ithebula 1). Imiphumela yokuhlolwa iwukubhekisela emtholampilo kuphela futhi akufanele isetshenziswe njengesisekelo sodwa sokwelashwa kweziguli ngabanye.
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Ukuguqulwa Kwezakhi Zofuzo Zomuntu ze-EML4-ALK Fusion
Le khithi isetshenziselwa ukuthola izinhlobo ezingu-12 zokuguqulwa kwezakhi zofuzo ze-EML4-ALK ezilinganisweni zeziguli zomdlavuza wamaphaphu ezingezona ezincane ezitholakala kubantu ngaphandle kokusebenzisa i-vitro. Imiphumela yokuhlolwa iwukubhekisela emtholampilo kuphela futhi akufanele isetshenziswe njengesisekelo sokwelashwa kweziguli ngakunye. Odokotela kufanele benze izahlulelo eziphelele ngemiphumela yokuhlolwa ngokusekelwe ezicini ezifana nesimo sesiguli, izinkomba zemithi, impendulo yokwelashwa, kanye nezinye izinkomba zokuhlolwa kwelabhorethri.
