I-Carbapenase

Incazelo emfushane:

Le khithi isetshenziselwa ukuthola ama-carbapenema e-NDM, KPC, OXA-48, IMP kanye ne-VIM akhiqizwa kumasampula ebhaktheriya atholakale ngemuva kokukhuliswa kwe-in vitro.

Sithumelele i-imeyili

Imininingwane Yomkhiqizo

Amathegi Omkhiqizo

Igama lomkhiqizo

Ikhithi Yokuthola I-HWTS-OT085E/F/G/H -Carbapenemase (iGolide le-Colloidal)

I-Epidemiology

Ama-antibiotic e-Carbapenem angama-antibiotic angavamile e-β-lactam ane-spectrum ebanzi kakhulu yokulwa namagciwane kanye nomsebenzi onamandla kakhulu wokulwa namagciwane^[1]Ngenxa yokuqina kwayo ku-β-lactamase kanye nobuthi obuphansi, isibe ngomunye wemithi ebaluleke kakhulu yokulwa namagciwane ekwelapheni izifo ezibangelwa amagciwane ezinzima. Ama-Carbapenems aqinile kakhulu kuma-β-lactamases anwetshiwe asebenzisa i-plasmid (ama-ESBL), ama-chromosomes kanye nama-cephalosporinases asebenzisa i-plasmid (ama-enzyme e-AmpC)^[2].

Amapharamitha Obuchwepheshe

Isifunda esiqondiwe	Ama-carbapenema e-NDM, KPC, OXA-48, IMP kanye ne-VIM
Izinga lokushisa lesitoreji	4℃ -30℃
Uhlobo lwesampula	Amasampula ebhaktheriya atholakale ngemuva kokukhuliswa
Isikhathi sokuphelelwa yisikhathi	Izinyanga ezingama-24
Izinsimbi ezisizayo	Akudingeki
Izinto Ezisetshenziswayo Ezengeziwe	Akudingeki
Isikhathi sokutholwa	Amasampula ebhaktheriya atholakale ngemuva kokukhuliswa
I-LoD	Uhlobo lwe-NDM:0.15ng/mL Uhlobo lwe-KPC: 0.4ng/mL Uhlobo lwe-OXA-48:0.1ng/mL Uhlobo lwe-IMP:0.2ng/mL Uhlobo lwe-VIM:0.3ng/mL.
Umphumela we-hook	Ku-NDM, KPC, OXA-48 uhlobo lwe-carbapenemase, akukho mphumela we-hook otholakala ebangeni lika-100ng/mL; ku-IMP, uhlobo lwe-VIM lwe-carbapenemase, akukho mphumela we-hook otholakala ebangeni lika-1μg/mL.