● I-Mycobacterium Tuberculosis
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I-Mycobacterium Tuberculosis Nucleic Acid and Rifampicin(RIF)，Isoniazid Resistance(INH)
Lo mkhiqizo ulungele ukutholwa kwekhwalithi ye-Mycobacterium tuberculosis DNA kumasampuli esikhwehlela somuntu ku-vitro, kanye nokuguqulwa kwe-homozygous endaweni engu-507-533 amino acid codon (81bp, indawo enquma ukumelana ne-rifampicin) yofuzo lwe-rpoB olubangela isifo sofuba i-Mycobacterium. ukumelana ne-rifampicin.
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I-Mycobacterium Tuberculosis I-Isoniazid Resistance Mutation
Le khithi ifanele ukutholwa kwekhwalithi yezindawo eziyinhloko zokuguqula amasampula esikhwehlela somuntu aqoqwe ezigulini ezine-Tubercle bacillus positive eziholela ekumelaneni ne-mycobacterium tuberculosis isoniazid: Isifunda se-InhA sokukhuthaza -15C>T, -8T>A, -8T>C;Isifunda somgqugquzeli we-AhpC -12C>T, -6G>A;ukuguqulwa kwe-homozygous kwe-KatG 315 codon 315G>A, 315G>C.
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I-Mycobacterium Tuberculosis Rifampicin Resistance
Le khithi ifanele ukutholwa kwekhwalithi yokuguqulwa kwe-homozygous endaweni engu-507-533 ye-amino acid ye-codon yofuzo lwe-rpoB ebangela ukumelana ne-Mycobacterium tuberculosis rifampicin.
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I-Mycobacterium Tuberculosis Nucleic Acid kanye ne-Rifampicin Resistance
Le khithi ifanele ukutholwa kwekhwalithi ye-Mycobacterium tuberculosis DNA kumasampuli esikhwehlela somuntu ku-vitro, kanye nokuguqulwa kwe-homozygous endaweni engu-507-533 ye-amino acid ye-codon yofuzo lwe-rpoB ebangela ukumelana ne-Mycobacterium tuberculosis rifampicin.
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I-Mycobacterium Tuberculosis INH Ukumelana
Le khithi isetshenziselwa ukuthola ngokufanelekile ukuguqulwa kofuzo kwe-amino acid engama-315 yofuzo lwe-katG (K315G>C) kanye nokuguqulwa kofuzo kwesifunda somgqugquzeli wofuzo lwe-InhA (- 15 C>T).
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I-Mycobacterium Tuberculosis DNA
Ilungele ukutholwa kwekhwalithi ye-Mycobacterium tuberculosis DNA kumasampula esikhwehlela somtholampilo womuntu, futhi ifanele ukuxilonga okuyisizayo kwe-Mycobacterium tuberculosis infection.
