Amakhithi Okuthola Ama-Carbapenemases Okusika -Umphetho

I-CRE, evezwe neingozi ephezulu yokutheleleka, ukufa okuphezulu, izindleko eziphezulu kanye nobunzimaekwelashweni, kudingaukutholwa okusheshayo, okusebenzayo nokunembileizindlela zokusiza ukuxilongwa nokuphathwa kwezifo emtholampilo.

Ngokusho kwe-Study of the higher institutions and hospitals, i-Rapid Carbapenemases Detection Kit (Colloidal Gold) evela ku-Macro & Micro -Test, elingana ne-multi-qPCR assay, inikeza ukunemba okuphelele okungu-100% ekuboneni ama-carbapenemases kuma-isolates amabhaktheriya. Lokhu kusebenza okuvelele kudlula izindlela zendabuko ze-phenotypic njenge-mCIM/eCIM kanye ne-CDT. Okubaluleke kakhulu, ukuhlolwa kwegolide le-colloidal kubonisa ukuzwela okungu-100%, ukucaca, inani elihle lokubikezela, kanye nenani elibi lokubikezela le-carbapenemase ngayinye ehlolwe, okugqamisa ukusebenza kwayo okumangalisayo nokungaguquguquki ekuboneni amabhaktheriya akhiqiza i-carbapenemase.

Inketho 1:

OkusheshayoIkhithi Yokuthola Ama-Carbapenema (i-Colloidal Gold), intuthuko esezingeni eliphezulu yokuxazulula inkinga ephuthumayo ye-CRE esongela impilo yomphakathi yomhlaba wonke, izinsuku ezi-1-2 ngaphambi kwendlela yokuthambekela ezidakamizweni;

 imizuzu eyi-15ukuhlonza i-NDM, i-KPC, i-OXA-48, i-IMP kanye ne-VIM kuphela ekuhlolweni okukodwa;

 Ukusebenza okulula ngoketshezi lokukhulisa igazi ngaphandle kokukhulisa ipuleti, imizuzu eyi-10 kuphela yokuhlanza nokugeza;

 Ukuzwela Okuphezulu kanye nokungabikho kokusabela okuxubile namagciwane avamile e-pathogenic njenge-Klebsiella pneumoniae, i-Acinetobacter baumannii, i-Pseudomonas aeruginosa noma amanye amasampula akhiqiza i-β-lactamase;

 Ukusebenza Okubanzi: Izimo ezahlukahlukene ezifaka phakathi izibhedlela, imitholampilo, kanye nezikhungo zezempilo zomphakathi.

Inketho 2:

Ikhithi Yokuthola Izakhi Zofuzo Zokumelana Ne-Carbapenem (i-Fluorescence PCR), Ukuhlolwa okungu-6 ku-1nomphumela ngaphakathiimizuzu engama-40, ikhomba ngokunembileI-NDM, i-KPC, i-OXA23, i-OXA-48, i-IMP kanye ne-VIMesivivinyweni esisodwa;

 Ukusampula Okulula: Isikhwehlela, i-rectal swab noma amakholoni amsulwa;

 Izindleko Ezincishisiwe: Ama-targets angu-6 atholwe ngokuhlolwa okukodwa agwema ukuhlolwa okuphindaphindekayo;

 Ukuzwela Okuphezulu Nokucacisa: 1000CFU/mL ukuze kutholakale ukuzwela kanye nokungabi nokuhlangana nezinye izifo zokuphefumula noma amasampula aqukethe ezinye izakhi zofuzo ezingamelani nemithi i-CTX, i-mecA, i-SME, i-SHV, i-TEM, njll.;

 Ukuhambisana Okubanzi: Ngezinsimbi ezijwayelekile ze-PCR;