I-PCT/IL-6 Ihlanganisiwe

I-PCT iyisandulela se-calcitonin, okuyi-glycoprotein eyakhiwe ngama-amino acid ayi-116.Inani le-molecular cishe li-12.8kd.Ayinawo umsebenzi wamahomoni.Ngaphansi kwezimo ze-physiological, i-PCT ihlanganiswa ngokuyinhloko futhi ifihliwe ngamaseli e-thyroid C.Ngesikhathi sokutheleleka kwebhaktheriya, ama-macrophages nama-monocyte esibindini, i-lymphocytes namaseli e-endocrine emaphashini namathumbu emathunjini ahlanganisa futhi akhiphe inani elikhulu le-PCT ngaphansi kwesenzo se-endotoxin, i-tumor necrosis factor-α ne-interleukin-6, okuholela ekwandeni okukhulu. emazingeni e-serum PCT.
I-Interleukin-6 iyi-cytokine evezwa amasosha omzimba azalwa ngesikhathi sokulimala kokuqala nokutheleleka.Ikhiqizwa ama-fibroblasts, ama-monocytes/macrophages, ama-T lymphocyte, ama-lymphocyte e-B, amaseli e-epithelial, ama-keratinocyte, namaseli ahlukahlukene wesimila.I-IL-6 yakhiwe ngamaketanga amabili e-glycoprotein, elinye iketanga le-α elinesisindo samangqamuzana angama-80kd;enye iketango elingu-β elinesisindo semolekyuli esingu-130kd[5].Uma umzimba womuntu uvuswa ukuvuvukala, amazinga e-IL-6 akhuphuka ngokushesha, okubuye kulamule ukuphendula kwesigaba esibucayi sesibindi futhi kukhuthaze ukukhiqizwa kwamaprotheni esigaba esibucayi njenge-C-reactive protein (CRP) kanye ne-serum amyloid A (SAA). ).Ngakho-ke, i-IL-6 iwuphawu lokuqala lokukhuphuka lapho ukuvuvukala kwenzeka.