I-Cuman CYPY2C19 Gene Polymorphism

I-CYP2C19 ingenye yama-enzyme abaluleke kakhulu wezidakamizwa emndenini we-CYPP450. Ama-substrate amaningi e-endoGenous futhi cishe ama-2% ezidakamizwa zemitholampilo ahlanjululwa yi-CCP2C19, njenge-metabolism of antiplet aggregation inhibitors (njenge-anticonVelsel), ama-anticonVuls), ama-anticonVuls), ama-anticonVelsel), i-anticonVuls), i-anticonVuls (njll. izidakamizwa ezihlobene. Lezi zinguquko ze- * 2 (Rs4244285) no * 3 (Rs4986893)) zibangela ukuthi kulahlekelwe umsebenzi we-enzyme okufakwe yi-CYPMOlic Verstrate amandla, futhi ukhuphule ukuhlukunyezwa kwegazi okuhlobene ukugxila kwegazi. * 17 (Rs12248560) kungakhuphula umsebenzi we-enzyme okufakwe i-CYP2C19 gene, ukukhiqizwa kwe-metabolites esebenzayo, futhi uthuthukise ubungozi bokuphuma kweplatelet futhi wandise ubungozi bopha ukopha. Kubantu abane-metabolism ehamba kancane yezidakamizwa, ukuthatha imithamo ejwayelekile isikhathi eside kuzodala imiphumela emibi kakhulu nemiphumela emibi, ukulimala kohlelo lwe-hematopoietic, ukulimala kohlelo lwe-hematopopoitic, njll., Lokho kungaholela ekufeni ezimweni ezinzima. Ngokusho komehluko ngamunye ku-metabolism ehambelana nezidakamizwa, ngokuvamile ihlukaniswe yaba yi-phenotypes ezine, okungukuthi i-metabolism (um, * 17/1. * 1/7, * 1 ), I-Metagolism Ephakathi (IM, * 1/1/4, * 1/3), I-Slow Metabolism (PM, * 2/3, * 3, * * 3/4).