I-Human CYP2C19 Gene Polymorphism

I-CYP2C19 ingenye yama-enzyme abalulekile okuguqula umuthi emndenini we-CYP450. Ama-substrate amaningi e-endo native kanye nemithi ecishe ibe ngu-2% yezokwelapha aguqulwa yi-CYP2C19, njengokuguqulwa kwe-antiplatelet aggregation inhibitors (njenge-clopidogrel), i-proton pump inhibitors (i-omeprazole), i-anticonvulsants, njll. Ama-polymorphisms e-CYP2C19 gene nawo anomehluko ekhonweni le-metabolizing lemithi ehlobene. Lokhu kuguqulwa kwamaphuzu *2 (rs4244285) kanye *3 (rs4986893) kubangela ukulahlekelwa komsebenzi we-enzyme obhalwe yi-CYP2C19 gene kanye nobuthakathaka bekhono le-metabolizing substrate, futhi kwandise ukuhlushwa kwegazi, ukuze kubangele ukusabela okubi kwemithi okuhlobene nokuhlushwa kwegazi. *17 (rs12248560) ingandisa umsebenzi we-enzyme obhalwe yi-CYP2C19 gene, ukukhiqizwa kwama-metabolites asebenzayo, futhi ithuthukise ukuvinjelwa kokuhlanganiswa kwama-platelet futhi yandise ingozi yokopha. Kubantu abane-metabolism ehamba kancane yezidakamizwa, ukuthatha imithamo evamile isikhathi eside kuzobangela imiphumela emibi kakhulu: ikakhulukazi ukulimala kwesibindi, ukulimala kwesistimu ye-hematopoietic, ukulimala kwesistimu yezinzwa ephakathi, njll., okungaholela ekufeni ezimweni ezimbi kakhulu. Ngokusho komehluko ngamunye ku-metabolism yezidakamizwa ehambisanayo, ngokuvamile ihlukaniswe ngezinhlobo ezine, okungukuthi i-metabolism esheshayo kakhulu (UM,*17/*17,*1/*17), i-metabolism esheshayo (RM,*1/*1), i-metabolism ephakathi (IM, *1/*2, *1/*3), i-metabolism ehamba kancane (PM, *2/*2, *2/*3, *3/*3).