I-Human Cytomegalovirus (HCMV) Nucleic Acid

I-Human cytomegalovirus (HCMV) iyilungu eline-genome enkulu kunazo zonke emndenini we-herpes virus futhi ingabhala amaprotheni angaphezu kuka-200. I-HCMV inqunyelwe kancane ebangeni layo labantu, futhi akukabikho imodeli yesilwane yokutheleleka kwayo. I-HCMV inomjikelezo wokuphindaphinda ohamba kancane node ukuze yakhe umzimba wokufakwa ngaphakathi kwe-nuclear, futhi ibangele ukukhiqizwa kwemizimba yokufakwa kwe-perinuclear kanye ne-cytoplasmic kanye nokuvuvukala kwamaseli (amaseli amakhulu), yingakho igama libizwa kanjalo. Ngokusho kokungafani kwe-genome yayo kanye ne-phenotype, i-HCMV ingahlukaniswa ibe izinhlobo ezahlukene, phakathi kwazo kukhona ukuhlukahluka okuthile kwe-antigenic, nokho, okungenalo ukubaluleka komtholampilo.

Ukutheleleka kwe-HCMV kuwukutheleleka okujwayelekile, okubandakanya izitho eziningi zomzimba, kunezimpawu eziyinkimbinkimbi nezihlukahlukene, ikakhulukazi kuthule, futhi kungabangela iziguli ezimbalwa ukuba zibe nezilonda zezitho eziningi okuhlanganisa i-retinitis, i-hepatitis, i-pneumonia, i-encephalitis, i-colitis, i-monocytosis, kanye ne-thrombocytopenic purpura. Ukutheleleka kwe-HCMV kuvame kakhulu futhi kubonakala sengathi kusakazeka emhlabeni wonke. Kuvame kakhulu kubantu, ngamazinga okusabalala angu-45-50% kanye nangaphezu kuka-90% emazweni athuthukile nasathuthuka, ngokulandelana. I-HCMV ingalala emzimbeni isikhathi eside. Uma amasosha omzimba esebuthakathaka, igciwane lizosebenza ukuze libangele izifo, ikakhulukazi ukutheleleka okuphindaphindiwe ezigulini ezine-leukemia kanye neziguli ezifakelwe ezinye, futhi lingabangela i-necrosis yezitho ezifakelwe ezinye futhi libeke impilo yeziguli engozini ezimweni ezimbi kakhulu. Ngaphezu kokuzalwa kwengane isishonile, ukuphuphuma kwesisu kanye nokubeletha ngaphambi kwesikhathi ngokutheleleka kwangaphakathi kwesibeletho, i-cytomegalovirus nayo ingabangela ukukhubazeka kokuzalwa, ngakho ukutheleleka kwe-HCMV kuyakwazi ukuthinta ukunakekelwa kwangaphambi kokubeletha kanye nokunakekelwa kwangemva kokubeletha kanye nekhwalithi yabantu.