I-Human Cytomegalovirus (HCMV) Nucleic Acid

I-cytomegalovirus yomuntu (HCMV) iyilungu eline-genome enkulu kunazo zonke emndenini we-herpes virus futhi ingafaka amaprotheni angaphezu kuka-200. I-HCMV ikhawulelwe kancane ebangeni elibambayo kubantu, futhi akukabi khona imodeli yezilwane yokutheleleka kwayo. I-HCMV inomjikelezo wokuphindaphinda ohamba kancane futhi omude ukuze wakhe umzimba wokufakwa kwe-intranuclear, futhi uqalise ukukhiqizwa kwemizimba ye-perinuclear kanye ne-cytoplasmic kanye nokuvuvukala kwamangqamuzana (amangqamuzana amakhulu), yingakho igama. Ngokusho kwe-heterogeneity ye-genome yayo kanye ne-phenotype, i-HCMV ingahlukaniswa ibe yizinhlobonhlobo zezinhlobonhlobo, phakathi kwazo kukhona ukuhlukahluka okuthile kwe-antigenic, okuyinto, nokho, engenakho ukubaluleka komtholampilo.

Ukutheleleka kwe-HCMV ukutheleleka kwesistimu, okubandakanya ngokomtholampilo okubandakanya izitho eziningi, kunezimpawu eziyinkimbinkimbi futhi ezihlukahlukene, ngokuvamile kuthule, futhi kungabangela iziguli ezimbalwa ukuba zithole izilonda zezitho eziningi ezihlanganisa i-retinitis, i-hepatitis, i-pneumonia, i-encephalitis, i-colitis, i-monocytosis, ne-thrombocytopenic purpura. Ukutheleleka kwe-HCMV kuvame kakhulu futhi kubonakala kwanda emhlabeni wonke. Idlange kakhulu kubantu, ngezinga lezehlakalo lika-45-50% nangaphezulu kwama-90% emazweni athuthukile nasathuthuka, ngokulandelana. I-HCMV ingalala ithule emzimbeni isikhathi eside. Uma amasosha omzimba esebuthakathaka, leli gciwane lizosebenza ukuze libangele izifo, ikakhulukazi izifo ezivame ukuvela ezigulini ze-leukemia kanye neziguli zokufakelwa kabusha, futhi lingabangela i-necrosis yesitho esifakwe kabusha futhi ibeke engozini impilo yeziguli ezimweni ezimbi kakhulu. Ngaphezu kokubeletha, ukuphuphuma kwesisu kanye nokubeletha ngaphambi kwesikhathi nge-intrauterine infection, i-cytomegalovirus ingase ibangele ukukhubazeka kokuzalwa, ngakho-ke ukutheleleka kwe-HCMV kukwazi ukuphazamisa ukunakekelwa ngaphambi kokubeletha kanye nangemuva kokubeletha kanye nekhwalithi yabantu.