I-Human Cytomegalovirus (HCMV) Nucleic Acid

I-cytomegalovirus yomuntu (HCMV) iyilungu eline-genome enkulu kunazo zonke emndenini we-herpes virus futhi ingafaka amaprotheni angaphezu kuka-200.I-HCMV ikhawulelwe kancane ebangeni elibambayo kubantu, futhi akukabi bikho imodeli yezilwane yokutheleleka kwayo.I-HCMV inomjikelezo wokuphindaphinda ohamba kancane futhi omude ukuze wenze umzimba wokufakwa kwe-intranuclear, futhi uqalise ukukhiqizwa kwemizimba ye-perinuclear ne-cytoplasmic inclusion kanye nokuvuvukala kwamaseli (amangqamuzana amakhulu), yingakho igama.Ngokusho kwe-heterogeneity ye-genome yayo kanye ne-phenotype, i-HCMV ingahlukaniswa ibe yizinhlobonhlobo zezinhlobonhlobo, phakathi kwazo kukhona ukuhlukahluka okuthile kwe-antigenic, okuyinto, nokho, engenakho ukubaluleka komtholampilo.

Ukutheleleka kwe-HCMV ukutheleleka okuhlelekile, okubandakanya ngokomtholampilo okubandakanya izitho eziningi, kunezimpawu eziyinkimbinkimbi futhi ezihlukahlukene, ngokuvamile kuthule, futhi kungabangela iziguli ezimbalwa ukuba zithole izilonda zezitho eziningi ezihlanganisa i-retinitis, i-hepatitis, i-pneumonia, i-encephalitis, i-colitis, i-monocytosis, ne-thrombocytopenic. i-purpura.Ukutheleleka kwe-HCMV kuvame kakhulu futhi kubonakala kwanda emhlabeni wonke.Idlange kakhulu kubantu, ngezinga lezehlakalo lika-45-50% nangaphezulu kwama-90% emazweni athuthukile nasathuthuka, ngokulandelana.I-HCMV ingalala ithule emzimbeni isikhathi eside.Uma amasosha omzimba esebuthakathaka, leli gciwane lizosebenza ukuze libangele izifo, ikakhulukazi izifo ezivame ukuvela ezigulini ze-leukemia kanye neziguli zokufakelwa kabusha, futhi lingabangela i-necrosis yesitho esifakwe kabusha futhi sibeke engozini impilo yeziguli ezimweni ezimbi kakhulu.Ngaphezu kokubeletha, ukuphuphuma kwesisu kanye nokubeletha ngaphambi kwesikhathi nge-intrauterine infection, i-cytomegalovirus ingase ibangele ukukhubazeka kokuzalwa, ngakho-ke ukutheleleka kwe-HCMV kukwazi ukuphazamisa ukunakekelwa kwangaphambi kokubeletha kanye nangemuva kokubeletha kanye nekhwalithi yabantu.