I-Human Cytomegalovirus (HCMV) NUCLEIC ACE

I-Human Cytomegalovirus (HCMV) iyilungu eline-genome enkulu kunazo zonke emndenini we-herus virus futhi ingafaka amaprotheni angaphezu kwama-200. I-HCMV ivinjelwe kancane ebangeni layo ebangeni, futhi akukho hlobo lwezilwane lokutheleleka kwalo. I-HCMV inomjikelezo we-slow and ende wokuphindaphinda ukwakha umzimba wokufaka i-intranuclear, futhi kubangele ukukhiqizwa kwezinhlaka ze-Perinuclear and Cytoplasmic inking kanye nokuvuvukala kwamaseli (amaseli amakhulu), yingakho igama. Ngokusho kwe-heterogeneity ye-genome yayo ne-phenotype, i-HCMV ingahlukaniswa ibe yizinhlobonhlobo eziningi, phakathi kwazo kunokuhlukahluka okuthile kwe-antigenic, noma kunjalo, akubanga iqiniso lomtholampilo.

Ukutheleleka kwe-HCMV kungukutheleleka okuhleliwe, okuhilela izitho eziningi, kunezimpawu eziyinkimbinkimbi futhi ezahlukahlukene, futhi kuzwakale kakhulu iziguli, futhi kungadala iziguli ezimbalwa ukuthuthukisa i-retinitis, futhi kungenza i-monocytosis, i-colitis, monocytosis, kanye ne-thrombocytopenic purpura. Ukutheleleka kwe-HCMV kuvame kakhulu futhi kubonakala sengathi kuyasakazeka emhlabeni wonke. Igcwele kakhulu kubantu, ngezigameko zamanani angama-45-50% angaphezu kwama-90% emazweni athuthukisiwe futhi athuthukayo, ngokulandelana. I-HCMV ingalala i-durmant emzimbeni isikhathi eside. Lapho ukungavikeki komzimba sekubuthakathaka, leli gciwane lizosebenza ukuthi libangele izifo, ikakhulukazi izifo eziphindaphindwayo ezigulini ze-leukemia nasezintengiselwano ezitshaliwe, futhi kungadala impilo yeziguli ezimweni ezinzima. Ngaphezu kokushiswa kokubeletha, ukuphuphuma kwesisu nokulethwa ngaphambi kwesikhathi ngokutheleleka nge-intrauterine, i-cytomegalovirus ingadala ukungalungisi kokuzala, ngakho ukutheleleka kwe-HCMV kuyakwazi ukuthinta indawo yokunakekelwa kwangaphambi kokubeletha nekhwalithi yabantu.